专利号:US-5880295-A 优先权日:1994-02-16 标 题 :Process for the preparation of diamine intermediates useful in the synthesis of HIV protease inhibitors 发明人:KALTENBACH III ROBERT FRANK 权利人:DU PONT PHARM CO 摘要:The present invention provides a process for the preparation of compounds of formula (V) below, and analogs thereof, which are useful as intermediates for the synthesis of HIV protease inhibitors, including cyclic ureas. ##STR1##
专利号:US-5847149-A 优先权日:1994-01-27 标 题 :Thiadiazole derivatives, process for their preparation, and their use as precursors for the production of liquid crystals 发明人:FUSS ROBERT WALTER; MANERO JAVIER; SCHLOSSER HUBERT; WINGEN RAINER 权利人:HOECHST AG 摘要:Thiadiazole derivatives of the formula (I) n n X-B-A.sup.1 -(M.sup.1 -A.sup.2 -).sub.m (M.sup.2 -A.sup.3).sub.n -R.sup.1(I n n ) n in which the symbols and indices have the following meanings: n X is Cl, Br or I; n B is 1,3,4-thiadiazole-2,5-diyl; n A 1 , A 2 and A 3 are identical or different and are substituted or unsubstituted 1,4-phenylene, pyrazine-2,5-diyl, pyridazine-3,6-diyl, pyridine-2,5-diyl, pyrimidine-2,5-diyl, trans-1,4-cyclohexylene, 1,3,4-thiadiazole-2,5-diyl, 1,3-dioxane-2,5-diyl, 1,3-dithiane-2,5-diyl, 1,3-thiazole-2,4-diyl, 1,3-thiazole-2,5-diyl, thiophene-2,4-diyl, thiophene-2,5-diyl, piperazine-1,4-diyl, piperazine-2,5-diyl, naphthalene-2,6-diyl, bicyclo 2.2.2!octane-1,4-diyl, or 1,3-dioxaborinane-2,5-diyl; n M 1 and M 2 are identical or different and are --CO--O--, --O--CO--, --O--CO--O--, --O--CS--O--, --CH 2 --O--, --O--CH 2 --, --CHâ•?CH--, --C.tbd.C-- or a single bond; n R 1 is --O-benzyl, H, an alkyl group having 1 to 12 carbon atoms or an alkoxy group having 1 to 12 carbon atoms; n m and n are 0 or 1. n The novel compounds allow the synthesis of a wide range of 1,3,4-thiadiazole derivatives, as employed, for example, as components of liquid-crystal mixtures, in a significantly reduced number of synthesis stes.
专利号:WO-2023237381-A1 优先权日:2022-06-09 标题:Process for the synthesis of polyethylenes or copolymers of ethylene and 1,3-diene having a terminal ketone function 发明人:BOISSON CHRISTOPHE; D'AGOSTO FRANCK; DESGRANGES ARIANE; NGO ROBERT; JEAN-BAPTISTE-DIT-DOMINIQUE FRANÇOIS 权利人:MICHELIN & CIE; CENTRE NAT RECH SCIENT; ECOLE SUPERIEURE DE CHIMIE PHYSIQUE ELECTRONIQUE LYON; UNIV CLAUDE BERNARD LYON 摘要:The invention relates to a method for preparing a polyethylene having a terminal ketone function or a copolymer of ethylene and a 1,3-diene and optionally a vinyl aromatic compound which contains more than 50 mol% of ethylene and has a terminal ketone function; said method comprises a polymerization reaction of the monomers in the presence of a borohydrido-neodymocene complex and an organo-magnesium compound, followed by a coupling reaction with a compound having a nitrile function, and then a hydrolysis reaction.
专利号:US-7368616-B2 优先权日:2002-10-30 标题 :Method for the production of monomers useful in the manufacture of semiconductive polymers 发明人:WALLACE PAUL; TOWNS CARL; POUNDS THOMAS 权利人:MERCK PATENT GMBH 摘要:The instant invention relates to a new method for the synthesis of monomers and their use inter alia in the manufacture of semiconductive polymers. Monomers, in particular, asymmetric monomers, such as asymmetric fluorene compounds, are valuable material in the manufacture of semiconductive polymers. The know methods for producing asymmetric monomers, such as asymmetric fluorene compounds, are expensive due to the formation of by-products. n The method according to the present invention avoids the formation of such by-products and is described in more detail in claims 1 to 14.
专利号:US-8535689-B2 优先权日:2007-10-01 标题 :Identification of bacterial autoinducer and use in treating bacterial pathogenicity 发明人:BASSLER BONNIE; SEMMELHACK MARTIN; HIGGINS DOUGLAS A; BOLITHO MEGAN EILEEN; KRAML KRISTINA M; NG WAI-LEUNG 权利人:BASSLER BONNIE; SEMMELHACK MARTIN; HIGGINS DOUGLAS A; BOLITHO MEGAN EILEEN; KRAML KRISTINA M; NG WAI-LEUNG; UNIV PRINCETON 摘要:A bacterial autoinducer, CAI-1, was purified and its structure identified. Methods for synthesis of the autoinducer and its analogues were elucidated. Methods of using the autoinducer or its analogues for treating bacterial pathogenicity and bio film formation are described. Methods for prevention and treatment of cholera are described. Synthetic (S)-3-hydroxytridecan-4-one functions as well as natural CAI-1 in repressing production of the virulence factor toxin co-regulated pilus (TCP). Strategies are described to manipulate bacterial quorum sensing in the clinical arena.
专利号:US-4367343-A 优先权日:1981-12-31 标 题:Synthesis of tetraalkylsilanes 发明人:TAMBORSKI CHRIST; SNYDER JR CARL E 权利人:US AIR FORCE 摘要:A mixture of tetraalkylsilanes is prepared by reacting a mixture of at least two organometallic compounds with a silicon tetrahalide or an alkyl silicon trihalide. The mixture of silanes is useful as a hydraulic fluid.
摘要:Alonso, D. A.; Nájera, C., Science of Synthesis, (2010) 45, 243. 摘要:Alonso, D. A.; Nájera, C., Science of Synthesis, (2010) 47, 463. 摘要:Alonso, D. A.; Nájera, C., Science of Synthesis, (2010) 47, 451. 摘要:Kantchev, E. A. B.; Organ, M. G., Science of Synthesis, (2009) 48, 77. 摘要:Kantchev, E. A. B.; Organ, M. G., Science of Synthesis, (2009) 48, 38.