CAS: 13389-03-2; 2-Amino-8-Bromo-9-((2R,4S,5R)-4-Hydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-yl)-1H-Purin-6(9H)-One

相似化合物

4016-63-1 961-07-9 207121-55-9

上下游产品

2'-Deoxyguanosine 2'-deoxy-3',5'-bis-O-(triisopropylsilyl)guanosine 3',5'-di-O-acetyl-2'-deoxyguanosine 8-(benzyloxy)-2'-deoxyguanosine 2-amino-8-bromo-1H-purin-6(9H)-one N'-[8-Bromo-9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl]-N,N-dimethyl-formamidine 2'-Deoxyguanosine

2'-脱氧鸟苷置于n-溴代丁二酰亚胺(Nbs)体系中,用 水,乙腈 用作溶剂,化学反应 0.75H,以91%的收率获得8-溴-2'-脱氧鸟苷
参考文献:丙炔化嘌呤脱氧核苷:荧光成像策略的新工具
标题:丙炔化嘌呤脱氧核苷:荧光成像策略的新工具
摘要:生物过程的体内成像是现代细胞生物学的重要资产.这里的选择性反应荧光团是一个重要的工具,点击化学反应在这些事件中占有很大的份额.5-Ethynyl-2'-Deoxyuridine (Edu) 以可视化 Dna 复制而闻名,但对掺入 Dna 没有任何选择性.为了实现病毒复制,特别是 Hiv 复制的特定可视化,制备了一系列炔丙基化嘌呤脱氧核苷,旨在通过 Hiv 逆转录酶 (Rt) 选择性掺入.我们在此报告这些核苷类似物的合成和初步生物学效应(细胞毒性,Hiv 抑制效应和点击反应的可行性).
Doi:10.3390/molecules24030468

专利信息

专利号:WO-2017097973-A1
优先权日:2015-12-09
标题 :Modified nucleosides
发明人：MARX ANDREAS; WELTER MORITZ; BALINTOVÃ? JANA
权利人:UNIV KONSTANZ
摘要:The present invention relates to modified nucleosides which are linked to cargo molecules and which can be incorporated by DNA or RNA polymerases in strand synthesis. The present invention also relates to use of such modified nucleosides as substrates for DNA or RNA polymerases. The present invention also relates to the use of such modified nucleosides in diagnosis and prognosis of diseases or disorders associated with a target sequence. The present invention also relates to methods for producing such modified nucleosides, kits comprising such nucleosides, and in vitro methods for diagnosing or predicting diseases or disorders associated with a target sequence. The present invention also relates to modified nucleosides for use in diagnosing, predicting or treating diseases or disorders associated with a target sequence.