己二酸,聚合2,2-二甲基-1,3-丙二醇和2,5-呋喃二酮,苯酸酯置于1,2-Bis(Dimethylsilyl)Ethane,三(五氟苯基)硼烷体系中,用 二氯甲烷 用作溶剂,化学反应 12.0H,以62%的收率获得苯乙醚 参考文献:由b(c醚取代的醇与羰基化合物的化学选择性脱氧6 ˚f 5)3-催化还原(hme 2 Sich 2)2 † 标题:由b(c醚取代的醇与羰基化合物的化学选择性脱氧6 ˚f 5)3-催化还原(hme 2 Sich 2)2 † 摘要:使用(hme 2 Sich 2)2作为还原剂,开发了b(c 6 F 5)3催化的醚取代的醇和羰基化合物的脱氧反应.这种独特的试剂显示出优于传统的以硅为中心的氢硅烷的独特优势,可高收率地提供相应的烷烃,并对醚,芳基卤化物和烯烃具有非常好的耐受性.对照实验表明(hme 2 Sich 2)2可能以分子内si / O活化方式促进该方法. Doi:10.1039/c8Cc01163J
专利信息
专利号:US-10253153-B2 优先权日:2015-04-24 标题 :Linker and support for solid phase synthesis of nucleic acid, and production method of nucleic acid using said support 发明人:MAETA ERI; MORI KENJIRO; HORIE SHOHEI; ITO TAKAHIKO; SAITO SHOICHIRO; NAGAO RYUHEI 权利人:NITTO DENKO CORP 摘要:The present invention provides a linker for solid phase synthesis of nucleic acid, which consists of a compound represented by the formula (I) or the formula (II), a support for solid phase synthesis of nucleic acid, which has a structure represented by the formula (III), and a production method of a nucleic acid, which uses the support: n nwherein each symbol is as defined in the SPECIFICATION.
专利号:WO-2011101864-A1 优先权日:2010-02-17 标题 :Novel process for the synthesis of phenoxyethyl derivatives 发明人:JAIN RAJESH; JAGDEESHWAR RAO R; MAHENDER RAO SIRIPRAGADA 权利人:PANACEA BIOTEC LTD; JAIN RAJESH; JAGDEESHWAR RAO R; MAHENDER RAO SIRIPRAGADA 摘要:The present invention provides an improved process for the synthesis of 2-[2- (2,2,2-trifluoroethoxy)phenoxy]ethanol intermediate, its derivatives and/or its pharmaceutically acceptable salts, useful in the synthesis of α-1 adrenoceptor blockers such as silodosin.
专利号:WO-0140193-A1 优先权日:1999-12-03 标题:Method for the synthesis of pyrazolines 发明人:BOLDI ARMEN M 权利人:CHEMRX ADVANCED TECHNOLOGIES I; BOLDI ARMEN M 摘要:The present invention provides a method for the synthesis of compounds of Formula (I). Also claimed are novel intermediates and their methods of synthesis.
专利号:WO-2017063617-A1 优先权日:2015-10-13 标 题 :Preparation of intermediates for the synthesis of canagliflozin and dapagliflozin 发明人:ZEZULA JOSEF; BABIAK PETR; HAJDUCH JAN 权利人:ZENTIVA KS 摘要:The present invention relates to a preparation method of the intermediates of structures la (for the synthesis of canagliflozin) and 1b (for the synthesis of dapagliflozin), where in structure la X is methyl and Ar represents 2-(5-(4-fluorophenyl)-thienyl) and in structure 1b X is chlorine and Ar represents 4-ethoxyphenyl.
专利号:US-2002103381-A1 优先权日:2000-11-30 标 题 :Method for the synthesis of pyrazolines 发明人:BOLDI ARMEN M 摘要:The present invention provides a method for the synthesis of compounds of Formula I: n n n Also claimed are novel intermediates and their methods of synthesis.
专利号:US-2024024497-A1 优先权日:2020-08-06 标 题:Methods for the synthesis of protein-drug conjugates 发明人:BORCHARDT ALLEN; HUGHES ROBERT MICHAEL 权利人:CIDARA THERAPEUTICS INC 摘要:The present invention relates to methods for the synthesis of conjugates useful for the treatment of viral infections, e.g., conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir or an analog thereof) linked to an Fc domain monomer.
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合成参考文献
参考文献:10.1107/s1600536811013213 摘要:Meng K, Wu C, Cao J, Ma P, Liu L. Bis(4-eth-oxy-phen-yl) sulfoxide. Acta Crystallogr Sect E Struct Rep Online. 2011 May 01;67(Pt 5):o1136. 参考文献:10.1107/s1600536811018472 摘要:Parthiban P, Ramkumar V, Park DH, Jeong YT. 2,4-Bis(2-eth-oxy-phen-yl)-7-methyl-3-aza-bicyclo-[3.3.1]nonan-9-one. Acta Crystallogr Sect E Struct Rep Online. 2011 Jun 01;67(Pt 6):o1475–6.