CAS: 1018678-50-6; 2-(Difluoromethyl)Benzaldehyde

该化合物是一种多用途芳烃藻,配有分子式C8H6F2O.该化合物的特点是附属于苯并二氟甲基亚胺的二氟甲基组(-CHF2),具有独特的电子和...

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799814-32-7 1018678-49-3 799814-30-5

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    专利信息


    专利号:US-9751874-B2
    优先权日:2014-12-17
    标题:Hydroxy containing FXR (NR1H4) modulating compounds
    发明人：GEGE CHRISTIAN; KINZEL OLAF; KREMOSER CLAUS; SCHMITT AARON C
    权利人:GILEAD SCIENCES INC
    摘要:The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

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    参考文献:10.1055/s-0032-1318063
    摘要:Copper-Mediated Difluoromethylation of (Hetero)Aryl Iodides and β-Styryl Halides. Synfacts. 2013 Jan 18;9(02):0205. doi: 10.1055/s-0032-1318063.
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