CAS: 94158-13-1; 2,2'-((4-Amino-3-Nitrophenyl)Azanediyl)Diethanol Hydrochloride

相似化合物

2871-01-4 18226-17-0 33229-34-4

专利信息

专利号:US-2025283053-A1
优先权日:2022-04-20
标 题 :Enhanced cell-free bacteriophage synthesis by genetic modulation of bacterial transcription/translation machinery (txtl) machinery
发明人：BROOKS RANI
权利人:THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
摘要:The present disclosure relates to compositions including or obtained from genetically modified bacterial host cells (e.g., E. coli ) and methods for using the same for cell-free bacteriophage synthesis (CFBS). In particular, the present technology relates to genetically modified E. coli that overexpress one or more of translation initiation factor IF-3 (infC), OxyS and CyaR and/or repress RecC subunit exonuclease RecBCD, and methods for using the same to obtain improved CFBS yields.

专利号:WO-2025059342-A1
优先权日:2023-09-13
标 题:Diversified bacteriophage synthesis and engineering platform
发明人：BROOKS RANI; SANDOVAL NICHOLAS
权利人:THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
摘要:The present disclosure provides modified bacterial cell lysate compositions and methods for using the same for cell-free bacteriophage synthesis (CFBS) to generate a broad range of bacteriophage species. Also disclosed herein are phage engineering methods for converting a lysogenic bacteriophage into a lytic bacteriophage, as well as methods for generating a genetically modified bacteriophage species that targets a broader range of bacterial host strains compared to the wild-type bacteriophage species.

专利号:US-12006540-B2
优先权日:2015-09-28
标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis
发明人：JU JINGYUE; LI XIAOXU; CHEN XIN; LI ZENGMIN; KUMAR SHIV; SHI SHUNDI; GUO CHENG; REN JIANYI; HSIEH MIN-KANG; CHIEN MINCHEN; TAO CHUANJUAN; ERTURK ECE; KALACHIKOV SERGEY; RUSSO JAMES J
权利人:UNIV COLUMBIA
摘要:Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

专利号:WO-2025090082-A1
优先权日:2023-10-26
标题:Scalable, economical synthesis of selenoneine and its analogs
发明人：SEYEDSAYAMDOST MOHAMMAD R; KAYROUZ CHASE M
权利人:UNIV PRINCETON
摘要:The present disclosure provides a rapid, facile, economical, and highly scalable method for producing selenoneine. The method involves SenA, hercynine, a selenosugar, and optionally a reductant, and a single, high-yielding enzymatic step in, e.g, aneutral-pH aqueous buffer and at ambient temperature. It can achieve yields of around 5 grams selenoneine per liter reaction with approximate costs of $100 per gram selenoneine.

专利号:US-12031126-B2
优先权日:2020-05-08
标 题 :Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence
发明人：LIU DAVID R; ANZALONE ANDREW VITO; LEVY JONATHAN MA; GAO XIN; PODRACKY CHRISTOPHER J
权利人:BROAD INST INC; HARVARD COLLEGE
摘要:The present disclosure provides systems, compositions, and methods for simultaneously editing both strands of a double-stranded DNA sequence at a target site to be edited. In some aspects, the systems comprise a first and second prime editor complex, wherein each of the first and second prime editor complexes comprises (1) a prime editor comprising (i) a nucleic acid programmable DNA binding protein (napDNAbp), and (ii) a polypeptide having an RNA-dependent DNA polymerase activity; and (2) a pegRNA comprising a spacer sequence, gRNA core, a DNA synthesis template, and a primer binding site, wherein the DNA synthesis template encodes a desired DNA sequence or a complement thereof, wherein the desired DNA sequence and the complement thereof form a duplex comprising an edited portion which integrates into the target site to be edited. In some aspects, the systems comprise a first, second, third, and fourth prime editor complex, each comprising a prime editor and a PEgRNA. Also provided herein are methods for simultaneously editing both strands of a double-stranded DNA sequence at a target site to be edited. Further provided herein are pharmaceutical compositions, polynucleotides, vectors, cells, and kits.

专利号:US-11891630-B2
优先权日:2017-08-08
标 题 :Bacteriophage engineering via semi-synthesis
发明人：MCFARLAND KIRSTY A; ROGERS MILES T; MCBRINE CONNOR; HOLDER JASON W
权利人:CHARLES STARK DRAPER LABORATORY INC
摘要:The present disclosure provides methods of generating recombinant bacteriophage genomes via semi-synthesis. Specifically, the present technology provides methods of integrating a heterologous nucleic acid sequence into a bacteriophage genome, and isolating recombinant bacteriophages that express the heterologous nucleic acid sequence.