CAS: 834-67-3; 4-((4-Bromophenyl)Sulfonyl)Morpholine

上下游产品

morpholine 4-bromobenzenesulfonyl chloride 4-bromo-benzenesulfonic acid ethyl ester sodium 4-bromobenzenesulfinate [(4-N-morpholine-4-sulfonyl)phenyl]boronic acid [[4-(5-formyl-2-furanyl)phenyl]sulfonyl]-morpholine 4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)sulfonyl)morpholine B°C-Trp(4-(morpholinosulfonyl)phenyl)-Gly-OEt

📜4-溴苯磺酰氯置于叔丁基过氧化氢,碘,一水合肼体系中,用 四氢呋喃,癸烷,1,2-二氯乙烷 作为反应溶剂,化学反应 1.5H,反应生成 4-(4-溴苯基磺酰)吗啉
参考文献:从磺酰肼和胺中碘催化快速合成磺酰胺†
标题:从磺酰肼和胺中碘催化快速合成磺酰胺†
摘要:通过碘与芳基磺酰肼的胺催化磺酰化反应,开发了一种新的磺酰胺合成方法.这种无金属的策略采用易于获得且易于处理的起始原料,催化剂和氧化剂,并且可以在温和条件下轻松进行,从而在短时间内即可以中等到极好的收率方便地获得各种磺酰胺.
DOI:10.1039/c5Ob02075A

专利信息

专利号:WO-2004020401-A1
优先权日:2002-09-02
标题 :Synthesis of sulfonamide derivatives
发明人：KALLIKAT JOHN; MANDAL ASHIS BARAN; GANESH SAMBASIVAM
权利人:SYNGENE INTERNAT PRIVATE LTD; KALLIKAT JOHN; MANDAL ASHIS BARAN; GANESH SAMBASIVAM
摘要:The novel method of synthesis of sulphonamide derivatives (I), comprising reaction of alkyl-4-halophenylsulfonate with an amine. Formula (I) wherein X is halogen and R1 and R2 are independently selected from group comprising (i) C1 to C15 alkyl, straight or branched, (ii) C3 to C15 cycloalkyl, substituted or unsubstituted, (iii) C2 to C15 alkenyl, straight or branched, (iv) C2 to C15 alkynyl, straight or branched, (v) phenyl or benzyl, substituted or unsubstituted, (vi) heterocycloalkyl, substituted or unsubstituted, (vii) hydrogen, (viii) form with the nitrogen to which they are attached a 3-7 membered heterocyclic moiety such as pyrolidine, piperidine, piperazine, imidazole, pyrazole, (ix) the alkyl in i) may be attached to a moiety selected from cycloalkyl or heterocycloalkyl, substituted or unsubstituted

专利号:US-9938258-B2
优先权日:2012-11-29
标 题:Substituted 2,3-dihydrobenzofuranyl compounds and uses thereof
发明人：BALOGLU ERKAN; SHECHTER SHARON; SHACHAM SHARON; MCCAULEY DILARA; SENAPEDIS WILLIAM; GOLAN GALI; KALID ORI
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to substituted 2,3-dihydrobenzofuranyl compounds, and more particularly to a compound represented by Structural Formula I: n nor a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.

专利号:US-9856241-B2
优先权日:2013-07-03
标 题:Substituted benzofuranyl and benzoxazolyl compounds and uses thereof
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to substituted benzofuranyl and substituted benzoxazolyl compounds, and more particularly to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula (A), or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.

专利号:CN-112679292-B
优先权日:2020-12-25
标 题 :Synthesis method of secondary sulfonamide compound