CAS: 75-99-0; Dalapon

该化合物是有机合成和农用化学生产中常用的中间体,其高反应性可归因于与碳苯基功能相邻的二氯甲基组,对在目标分子中引入二氯丙烷糖类很有价值. ~90%的纯度能确保诸如酯化,恐吓和核生殖替代等反应的一贯性能.这种化合物由于能够改变生物活动,在除草剂配方和制药研究中特别有用. 需要妥善处理,因为其腐蚀性性质和对水分的潜在敏感性. 建议在惰性条件下储存以保持稳定性.

结构式图片

欧盟法规

统一分类与标签ECHA物质工作场所安全标识要求ECHA物质C&L通报REACH预注册废弃物危险特性清单

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合成工艺路线路线简述

    2-氯丙酸置于phosphonic Acid,氯体系中,化学反应生成 2,2-二氯丙酸
    参考文献:Process For Making Alpha,Alphadihalopropionic Acids
    标题:Process For Making Alpha,Alphadihalopropionic Acids

    海关参考信息

    专利信息


    专利号:US-7304191-B2
    优先权日:2000-08-07
    标 题:Process for the synthesis of fluoroorganic compounds
    发明人:MATHIEU VERONIQUE; JANSSENS FRANCINE; FRANKLIN JAMES
    权利人:SOLVAY
    摘要:The present invention relates to a fluorination method for the synthesis of halofluoroorganic compounds which can be used, inter alia, as precursors in the synthesis of 2,3-unsaturated fluoroorganic carbonyl compounds comprising a fluorine substituent in the 2 position.

    专利号:US-7084281-B2
    优先权日:2003-01-22
    标题:Synthesis of dihalohydrins and tri- and tetra-substituted olefins
    发明人:FALCK JOHN R; BARMA DEB K; KUNDU ABHIJIT
    权利人:UNIV TEXAS
    摘要:A novel synthesis reaction for highly stereospecific tri- and tetra-substituted olefins is described. A single stereoisomer of stable α-halo-α,β-ester is produced in high yield by the reaction of aldehyde or ketone with a trihalogenated compound such as trichloroacetate in the presence of CrCl 2 in a solvent. By varying the amount of CrCl 2 used, the stable dihalohydrin intermediate may be obtained as well.

    专利号:WO-2024256370-A1
    优先权日:2023-06-13
    标 题 :Synthesis of glufosinate using an amidase-based process
    发明人:ZIMMERMANN GUNTHER; POTT MORITZ STEFAN
    权利人:BASF SE
    摘要:The present invention relates to a method of preparing glufosinate, comprising the steps of hydrolysing an N-carbamoyl glufosinate amide with an Amidase enzyme to form an N- carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N- carbamoyl amino acid compound.

    专利号:US-2025120400-A1
    优先权日:2021-12-10
    标题:Synthesis of glufosinate using a hydantoinase-based process
    发明人:DITRICH KLAUS; BREUER MICHAEL; POTT MORITZ STEFAN; ZIMMERMANN GUNTHER; SEEMAYER STEFAN
    权利人:BASF SE
    摘要:The present invention relates to a method of manufacturing glufosinate, comprising the steps of hydrolysing a hydantoin with a Hydantoinase enzyme to form a N-carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N-carbamoyl amino acid compound.

    专利号:WO-03064371-A1
    优先权日:2002-02-01
    标题 :Synthesis of fluorinating agents
    发明人:CLEMENT MANDY
    权利人:F2 CHEMICALS LTD; CLEMENT MANDY
    摘要:The invention provides a method for the preparation of an acyl hypofluorite (I), the method comprising treating a mixture comprising a lower nitrile and a carboxylic acid with elemental fluorine. The preferred acyl hypofluorite is acetyl hypofluorite, the corresponding carboxylic acid is acetic acid, and the preferred nitrile is acetonitrile. The reaction is preferably carried out in a single phase on a continuous basis at room temperature, by treating a mixture of nitrile and carboxylic acid with a stream containing 10% fluorine gas in an inert gas such as nitrogen.

    专利号:US-11919928-B2
    优先权日:2016-03-16
    标题 :Method for producing dihydrotentoxin
    发明人:KUBO TAKASHI; MACHIDA MASAYUKI; FUJIOKA TOMONORI; YAMAGUCHI Shigenari; KAWAI KIYOSHI
    权利人:KUMIAI CHEMICAL INDUSTRY CO
    摘要:An object of the present invention is to identify an enzyme having activity of synthesizing dihydrotentoxin that is a tentoxin precursor and an enzyme having activity of synthesizing tentoxin using dihydrotentoxin as a substrate. The present invention concerns a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 16 and having activity of nonribosomal peptide synthesis of dihydrotentoxin and a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 18 and having activity of converting dihydrotentoxin to tentoxin.
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    主要参考文献

    参考标题:Palladium-Catalyzed Synthesis Of Benzofurans Via C-H Activation/oxidation Tandem Reaction And Its Application To The Synthesis Of Decursivine And Serotobenine
    作者:Lei Guo,Fengying Zhang,Weimin Hu,Lei Li,Yanxing Jia
    摘要:A New Palladium-Catalyzed Method For The Synthesis Of Benzofurans By Reaction Of 2-Hydroxystyrenes And Iodobenzenes Via A C–h Activation/oxidation Tandem Reaction Has Been Unprecedentedly Discovered. By Using This Strategy, The Overall Synthetic Efficiency Of The Synthesis Of Decursivine And Its Analogues Was Indeed Improved. Preliminary Mechanistic Studies Shed Light Into The Possible Mechanisms.

    合成参考文献


    摘要:Fundamental and Applied Toxicology., 7(299), 1986
    摘要:Kenaga EE; Residue Rev 53: 109-151 (1974)
    摘要:O'Neil MJ, ed; Merck Index, 13th ed, Whitehouse Station, NJ Merck & Co. p 492 (2001)
    摘要:USEPA/Office of Water; Federal-State Toxicology and Risk Analysis Committee (FSTRAC). Summary of State and Federal Drinking Water Standards and Guidelines (11/93) To Present
    摘要:Kearney, P.C., and D. D. Kaufman (eds.) Herbicides: Chemistry, Degredation and Mode of Action. Volumes 1 and 2. 2nd ed. New York: Marcel Dekker, Inc., 1975., p. 405
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