CAS: 718-08-1; Ethyl 3-Oxo-4-Phenylbutanoate

上下游产品

ethyl 2-acetyl-3-oxo-4-phenylbutanoate tert-Butyl ethyl malonate phenylacetyl chloride hydrogen ethyl malonate 4-benzyl-5-hydroxy-7-methyl-coumarin ethyl 2-isopropyl-3-oxo-4-phenylbutanoate 2,4-dioxo-3,6-diphenyl-cyclohexanecarboxylic acid ethyl ester 4-benzyl-5,7-dihydroxy-coumarin

📜Ethyl 4-Phenylbuta-2,3-Dienoate置于oxone体系中,用 水,N,N-二甲基甲酰胺 作为反应溶剂,以58%的收率获得产物4-苯基乙酰乙酸乙酯
参考文献:Oxone-Promoted Hydration Of Electron-Deficient Allenic Esters And Ketones Into 1,3-Dicarbonyl Compounds
标题:Oxone-Promoted Hydration Of Electron-Deficient Allenic Esters And Ketones Into 1,3-Dicarbonyl Compounds
摘要:A Novel And Mild Protocol For The Hydration Of Electron-Deficient Allenic Esters And Ketones Into Various 1,3-Dicarbonyl Compounds Is Described. The Hydration Of Allenes Promoted By Oxone In Dmf Afforded The Corresponding Products In Moderate To Good Yields. This Work Features The Employment Of Only A Catalytic Amount Of Inexpensive And Nontoxic Solid Reagent Oxone (2Khso(5)Center Dot Khso4 Center Dot K2So4),Avoiding The Utility Of Toxic Metals Or Traditional Bronsted Acids,In A Green Version Of Viewpoint. A Possible Reaction Mechanism For This Transformation Is Also Primarily Proposed. (C) 2015 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Tetlet.2015.05.120

专利信息

专利号:US-5945559-A
优先权日:1996-05-24
标题:Process for producing 3-oxocarboxylic acid esters
发明人：SOTOGUCHI TSUKASA; YUASA YOSHIFUMI; TACHIKAWA AKIO; HARADA SHUNICHI
权利人:TAKASAGO PERFUMERY CO LTD
摘要:A novel process for producing 3-oxocarboxylic acid esters, which are useful as intermediates in the synthesis of ceramides to be used as a humectant, biodegradable polymers, drugs, etc., at a high purity and a high yield without requiring any troublesome procedure, is disclosed. The process comprises reacting an acetoacetic ester with a calcium compound, a barium compound or a strontium compound in the presence of an organic solvent at a temperature of 10 to 120 DEG C., further reacting the obtained product with a carboxylic acid chloride to thereby acylate it, and then adding thereto an alcohol in an amount 1 to 5 times by mol as much as the calcium compound, barium compound or strontium compound to thereby deacetylate the same.

专利号:CN-116837043-A
优先权日:2023-07-13
标题 :Application of a reductive aminase in asymmetric synthesis of chiral amines

专利号:CN-116837042-A
优先权日:2023-07-13
标题 :Application of a reductive aminase in asymmetric synthesis of chiral amines

专利号:CN-116622658-A
优先权日:2022-02-11
标题 :Mutant β-amino acid dehydrogenase and its application in the synthesis of aromatic β-amino acid compounds

专利号:US-4172199-A
优先权日:1975-01-02
标题 :O-2-isocephem-4-carboxylic acid derivatives as antibacterial agents
发明人：BELLEAU BERNARD R; CONWAY TERRY T; DOYLE TERRENCE W; LUH BING-YU
权利人:BRISTOL MYERS CO
摘要:There is described the stereoselective total synthesis by a variety of routes of novel suitably substituted DELTA 2,3-1,4-morpholine-2-carboxylic acids possessing a fused beta -lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula wherein Z is hydrogen or the residue of an ester group and X is acylamino. Also included in the invention are compounds of the above formula in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds. The compounds are potent antibacterial agents.

专利号:US-4113946-A
优先权日:1975-01-02
标题:Δ2,3 -1,4-Morpholine-2-carboxylic acid derivatives as antibacterial agents
发明人：BELLEAU BERNARD R; DOYLE TERRENCE W; LUH BING YU; CONWAY TERRY T
权利人:BRISTOL MYERS CO
摘要:There is described the stereoselective total synthesis by a variety of routes of novel suitably substituted Δ 2 ,3 -1,4-morpholine-2-carboxylic acids possessing a fused β-lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula ##STR1## wherein Q is hydrogen, alkyl, aralkyl or --CH 2 COOZ where Z is hydrogen or the residue of an ester group and X is amino, azido or acylamino. Also included in the invention are compounds of the above formula in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds. Those compounds in which X is acylamino and their physiologically hydrolyzed esters and pharmaceutically acceptable salts are potent antibacterial agents.