CAS: 68090-88-0; Boc-Phe(4-Cl)-Oh

相似化合物

51301-86-1 14091-08-8 14173-39-8

上下游产品

tert-butyl dicarbonatedi-tert-butyl dicarbonate DL-Phe(4Cl) N-(tert-butyloxycarbonyl) azide p-chlorophenylalanine-4-chlorophenylalanine 2-(trimethylsilyl)ethyl esterD,L-N-(1,1-dimethylethoxy)carbonyl-4-chlorophenylalanine 2-(trimethylsilyl)ethyl ester -4-chlorophenylalanine pentafluorophenyl esterD,L-N-(1,1-dimethylethoxy)carbonyl-4-chlorophenylalanine pentafluorophenyl ester -4-chlorophenylalanine 2-bromoethyl esterD,L-N-(1,1-dimethylethoxy)carbonyl-4-chlorophenylalanine 2-bromoethyl ester 2-(benzhydrylidene-amino)-3-(4-chloro-phenyl)-propionic acid allyl ester

对氯肉桂酸置于palladium On Activated Charcoal 盐酸,Lithium Hydroxide,正丁基锂,2,4,6-三异丙基苯磺酰叠氮化物,氢气,双(三甲基硅烷基)氨基钾,Potassium Carbonate,三乙胺体系中,用 四氢呋喃,甲醇,水 作为反应溶剂,-78.0~25.0 °C,101.33 Kpa 条件下,反应 24.87H,反应生成 Boc-L-4-氯苯丙氨酸
参考文献:A Formal Total Synthesis Of The Ace Inhibitor K-13. An Application Of Arene-Ruthenium Chemistry To Complex Chemical Synthesis
标题:A Formal Total Synthesis Of The Ace Inhibitor K-13. An Application Of Arene-Ruthenium Chemistry To Complex Chemical Synthesis
摘要:Stoichiometric Ruthenium Activation Of 4-Chlorophenylalanine Derivatives Toward Nucleophilic Substitution,Using Phenoxide Nucleophiles That Are Derived From Protected Dipeptides,Allowed The Formation Of Isodityrosine Derivatives That Are Synthetic Precursors To The Ace Inhibitor K-13. An Evaluation Of Carboxyl Blocking Groups Revealed That A 2-Bromoethyl Ester Is The Most Useful In Terms Of Its Compatibility With Ruthenium Complexation And Subsequent Nucleophile Addition But That Its Removal Is Problematic. Conversion To Iodoethyl Ester Using Finkelstein Reaction Conditions,In The Presence Of The Peptide And Amino Acid Functionality,Provided A Solution To This Problem,Since The Iodoethyl Group Was Easily Removed On Treatment With Samarium Diiodide.
DOI:10.1021/jo00088A009

专利信息

专利号:US-5783577-A
优先权日:1995-09-15
标题 :Synthesis of quinazolinone libraries and derivatives thereof
发明人：HOUGHTEN RICHARD A; OSTRESH JOHN M
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.

专利号:WO-9834113-A1
优先权日:1997-02-04
标题 :Combinatorial libraries of bicyclic guanidine derivatives and compounds therein
发明人：OSTRESH JOHN M; MEYER JEAN-PHILIPPE; DOOLEY COLETTE T; HOUGHTEN RICHARD A; BLONDELLE SYLVIE E; SCHONER CHRISTA C
权利人:TREGA BIOSCIENCES INC
摘要:The invention provides a rapid approach for combinatorial synthesis and screening of combinatorial libraries of bicyclic guanidine compounds. The present invention further provides the compounds made by the combinatorial synthesis and individually as well as methods of using the same.

专利号:US-6359144-B1
优先权日:1997-02-04
标 题 :Combinatorial libraries of bicyclic guanidine derivatives and compounds therein
发明人：OSTRESH JOHN M; MEYER JEAN-PHILIPPE; DOOLEY COLETTE T; BLONDELLE SYLVIE E; SCHONER CHRISTA C; HOUGHTEN RICHARD A
权利人:LION BIOSCIENCE AG
摘要:The invention provides a rapid approach for combinatorial synthesis and screening of combinatorial libraries of bicyclic guanidine compounds. The present invention further provides the compounds made by the combinatorial synthesis and individually as well as methods of using the same.

专利号:US-5663149-A
优先权日:1994-12-13
标 题:Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
发明人：PETTIT GEORGE R; SRIRANGAM JAYARAM K; KANTOCI DARKO
权利人:UNIV ARIZONA
摘要:The synthesis and elucidation of nineteen heterocyclic or halophenyl amideerivatives of dolastatin 10 are disclosed. These compounds and the methods of producing those compounds offer demonstrated significant in vitro activity against several human cancer cell lines. These compounds and the methods of producing those compounds offer a commercially viable alternative to natural and synthetic dolastatin 10.

专利号:CN-102241737-B
优先权日:2011-04-06
标 题 :Endomorphin-1 analogs and their synthesis and application in the preparation of analgesic drugs

专利号:CN-102241737-A
优先权日:2011-04-06
标 题:Endomorphin-1 analogs and their synthesis and application in the preparation of analgesic drugs