CAS: 58-55-9; 1,3-Dimethyl-1H-Purine-2,6(3H,9H)-Dione

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CAS号107-31-3 甲酸甲酯 | CAS号57533-87-6 3,7-Dihydro-1,3... | CAS号81281-58-5 7-氨基-1,3-二甲基-3,... | CAS号58-08-2 咖啡因 | CAS号226386-40-9 (1,3-Dimethyl-2... | CAS号80035-38-7 7-(2-acetamido-... | CAS号124093-03-4 1,3-dimethylxan... | CAS号122707-25-9 6-amino-1,3-dim... | CAS号7664-41-7 氨 | CAS号57-13-6 尿素 | CAS号74-89-5 氨基甲烷 | CAS号317-34-0 氨茶碱 | CAS号577-66-2 1H-Purine-2,6-d... | CAS号944-73-0 1,3-二甲基尿酸 | CAS号6136-37-4 3,7-二氢-1-甲基-1H-... | CAS号1076-22-8 3-甲基黄嘌呤 | CAS号1811-38-7 3-(1,3-dimethyl... | CAS号2099-73-2 1,3-二甲基-8-硝基-1H...

1,3-Dimethyl-5-Bromo-6-Methylaminopyrimidine-2,4-Dione置于sodium Azide体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,以47%的收率获得产物茶碱
参考文献:A High Chemical Reactivity Of 5-Azidouracils And Its Synthetic Application: Novel Synthesis Of 8-Substituted 1,3-Dimethylxanthine Derivatives
标题:A High Chemical Reactivity Of 5-Azidouracils And Its Synthetic Application: Novel Synthesis Of 8-Substituted 1,3-Dimethylxanthine Derivatives
摘要:A Novel Method For The Preparation Of 8-Substituted 1,3-Dimethylxanthine Derivatives (7 Or 8) Is Described: Treatment Of 6-Alkylamino-5-Bromo-1,3-Dimethyluracils (6A-E),Easily Prepared By Bromination Of The Corresponding 6-Alkylamino-1,3-Dimethyluracils (5),With Sodium Azide In Dmf At Ambient Temperature Allowed The Direct Formation Of The 8-Substituted 1,3-Dimethylxanthines (7) Proceeding Via A Transient Formation Of The Corresponding 5-Azido-1,3-Dimethyluracils. The 5-Bromo-1,3-Dimethyluracils (6F,G) Possessing An Ct-Branched Alkylamino Group At The 6-Position Similarly React With Sodium Azide To Afford 8,8-Disubstituted 1,3-Dimethyl-8H-Xanthines (8,8-Disubstituted 1,3-Dimethyl-3,G-Dihydropurine-2,6-Diones)(8).
DOI:10.3987/com-97-S68

专利信息

专利号:US-11542269-B2
优先权日:2018-01-03
标 题:Prins reaction and compounds useful in the synthesis of halichondrin macrolides and analogs thereof
发明人：CHOI HYEONG-WOOK; FANG FRANCIS G
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods utilizing Prins reaction in the preparation of compounds that may be useful as intermediates in the synthesis of halichondrin macrolides and analogs thereof. The invention also provides compounds that may be useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.

专利号:US-10913749-B2
优先权日:2015-05-07
标 题 :Macrocyclization reactions and intermediates and other fragments useful in the synthesis of halichondrin macrolides
发明人：FANG FRANCIS G; KIM DAE-SHIK; CHOI HYEONG-WOOK; CHASE CHARLES E
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of a halichondrin macrolides through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Horner-Wadsworth-Emmons olefination), catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.

专利号:US-11136335-B2
优先权日:2016-06-30
标题:Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof
发明人：CHASE CHARLES E; CHOI HYEONG-WOOK; ENDO ATSUSHI; FANG FRANCIS G; KIM DAE-SHIK
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of a halichondrin macrolides or analogs thereof through a cyclization reaction strategy. The strategy of the present invention involves subjecting an intermediate to Prins reaction conditions to afford a macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides or analogs thereof and methods for preparing the same.

专利号:US-8957230-B2
优先权日:2011-06-30
标 题 :Synthesis of cleistanthin A and derivatives thereof
发明人：MULIK NILESH SHRIDHAR; PANGHAVANE KAILASH DATTATRAYA
权利人:MULIK NILESH SHRIDHAR; PANGHAVANE KAILASH DATTATRAYA
摘要:The present invention provides a method for preparing Cleistanthin A, a diphyllin glycoside, derivatives thereof and intermediates thereto. In particular the present invention provides in one of the aspect a method for synthesis of compound of formula D a key intermediate of diphyllin, which can be carried out in a shorter duration and at an ordinary temperature.

专利号:US-2025235415-A1
优先权日:2022-02-23
标 题:Modulation of human breast milk composition
发明人：ROSS MICHAEL G; DESAI MINA
权利人:LUNDQUIST INST FOR BIOMEDICAL INNOVATION AT HARBOR UCLA MEDICAL CENTER
摘要:Compositions and methods for improving a child, such as an infant's health, are provided. The methods entail improving the quality of breast milk in a female human individual that provides breast milk, or expects to provide breast milk, to the child, by administering to the individual an agent that increases the individual's sensitivity to insulin, and/or an agent that reduces the substrate uptake, synthesis or secretion of long chain fatty acids, reduces the substrate uptake, synthesis or secretion of short chain fatty acids, increases the amino acid uptake, protein synthesis or protein secretion of proteins, or reduces the uptake or synthesis of lactose.

专利号:US-5955083-A
优先权日:1996-01-03
标 题 :Use of eriobotrya japonica extract, in particular in cosmetics for stimulating glycosaminoglycan synthesis
发明人：BONTE FREDERIC; DUMAS MARC
权利人:LVMH RECH
摘要:PCT No. PCT/FR97/00009 Sec. 371 Date Aug. 28, 1997 Sec. 102(e) Date Aug. 28, 1997 PCT Filed Jan. 3, 1997 PCT Pub. No. WO97/06659 PCT Pub. Date Feb. 27, 1997The invention concerns novel uses of an Eriobotrya japonica extract, in particular in cosmetics or pharmaceutics. This extract permits stimulation of glycosaminoglycan synthesis, in particular of hyaluronic acid, thus imparting to the cosmetic compositions containing this extract the properties of improving the firmness and suppleness of the skin, combating the formation of wrinkles or lessening the depth thereof, smoothing the surface of the skin by means of a tightening effect, or moisturizing the skin. The invention further concerns the use of these extracts for stimulating the synthesis of glycosaminoglycans from a cell culture medium, in particular fibroblasts or keratinocytes.