CAS: 4552-50-5; (7,7-Dimethyl-2-Oxobicyclo[2.2.1]Heptan-1-yl)Methanesulfonyl Chloride

上下游产品

CAS号76-26-6 [7,7-dimethyl-2... | CAS号25442-88-0 樟美君 | CAS号71242-58-5 (1S)-(-)-10-巯基异冰片 | CAS号71242-59-6 (1S)-(-)-10-巯基冰片

📜Camphor-10-Sulfonic Acid置于氯化亚砜,Calcium Carbonate体系中,化学反应生成 10-樟脑磺酰氯
参考文献:关于洪斯迪克和西蒙尼尼反应之间的关系
标题:关于洪斯迪克和西蒙尼尼反应之间的关系
摘要:结构不同的羧酸银(rco 2 Ag)已被氯,溴和碘降解.反应产生卤化物rx和/或酯rco 2 R,其主要产物取决于基团r的性质,所用的卤素和反应温度.酯的形成与rx + Rco 2 Ag->rco 2 R + Agx反应的成功之间存在相关性,这表明卤代烷是酯形成的中间体.讨论了hunsdiecker反应的合成适用性的局限性.
DOI:10.1016/s0040-4020(01)91697-7

专利信息

专利号:US-5840915-A
优先权日:1990-01-22
标题:Process for the enatioselective synthesis of intermediates used
发明人：LEE THOMAS BING KIN; WONG GEORGE SEUNG-KIT
权利人:HOECHST MARION ROUSSEL INC
摘要:A process for the stereoselective synthesis of [R]- and [S]-2,3-dihydro-1,3-dimethyl-2-oxo-1H-indole-3-acetonitriles comprises reacting racemic and 5-alkoxy-substituted (+/-)-1,3-dimethyloxindoles with a halogenated acetonitrile in the presence of a substituted N-benzyl cinchoninium, quinidinium, cinchonidinium, or quininium catalyst. The resulting alkylated oxindoles can be converted to primary amines by catalytic reduction in the presence of hydrogen gas. One of the primary amines, such as enantiomers of 3-(2-aminoethyl)-1,3-dihydro-1,3-dimethyl-5-methoxy-2H-indol-2-one, can be enriched by contact with a chiral tartaric acid in an amount sufficient to preferentially precipitate a salt of the chiral acid and one of the enantiomers. The product can be used in the synthesis of stereospecific forms of physostigmine and related compounds having pharmaceutical activity.

专利号:US-5274117-A
优先权日:1990-01-22
标 题:Process for the enantioselective synthesis of intermediates used in the preparation of physostigmine
发明人：LEE THOMAS BING KIN DR; WONG GEORGE S K
权利人:HOECHST ROUSSEL PHARMA
摘要:A process for the stereoselective synthesis of [R]- and [S]-2,3-dihydro-1,3-dimethyl-2-oxo-1H-indole-3-acetonitriles comprises reacting racemic and 5-alkoxy-substituted (+/-)-1,3-dimethyloxindoles with a halogenated acetonitrile in the presence of a substituted N-benzyl cinchoninium, quinidinium, cinchonidinium, or quininium catalyst. The resulting alkylated oxindoles can be converted to primary amines by catalytic reduction in the presence of hydrogen gas. One of the primary amines, such as enantiomers of 3-(2-aminoethyl)-1,3-dihydro-1,3-dimethyl-5-methoxy-2H-indol-2-one, can be enriched by contact with a chiral tartaric acid in an amount sufficient to preferentially precipitate a salt of the chiral acid and one of the enantiomers. The product can be used in the synthesis of stereospecific forms of physostigmine and related compounds having pharmaceutical activity.

专利号:EP-0438796-B1
优先权日:1990-01-22
标题:Process for the enantioselection synthesis of alkylated oxindoles used as intermediates in the preparation of physostigmine
发明人：LEE THOMAS BING KIN DR; WONG GEORGE S K
权利人:HOECHST MARION ROUSSEL INC
摘要:A process for the stereoselective synthesis of [R]- and [S]-2,3-dihydro-1,3-dimethyl-2-oxo-1H-indole-3-acetonitriles comprises reacting racemic and 5-alkoxy-substituted (+/-)-1,3-dimethyloxindoles with a halogenated acetonitrile in the presence of a substituted N-benzyl cinchoninium, quinidinium, cinchonidinium, or quininium catalyst. The resulting alkylated oxindoles can be converted to primary amines by catalytic reduction in the presence of hydrogen gas. One of the primary amines, such as enantiomers of 3-(2-aminoethyl)-1,3-dihydro-1,3-dimethyl-5-methoxy-2H-indol-2-one, can be enriched by contact with a chiral tartaric acid in an amount sufficient to preferentially precipitate a salt of the chiral acid and one of the enantiomers. The product can be used in the synthesis of stereospecific forms of physostigmine and related compounds having pharmaceutical activity.

专利号:US-6420599-B2
优先权日:1998-05-29
标 题:Chemical process for the stereoselective synthesis of R-(-)-carnitine
发明人：MARZI MAURO; TINTI MARIA ORNELLA; DE ANGELIS FRANCESCO
权利人:SIGMA TAU IND FARMACEUTI
摘要:A process is described for the stereoselective synthesis of R-(-)-carnitine in which the characterizing step is condensation of glycerol with an amine of (-)camphorsulfonic acid.

专利号:US-8859765-B2
优先权日:2011-11-30
标 题:Process for the manufacture of chiral catalysts and their salts
发明人：WU PING-YU; HENSCHKE JULIAN PAUL
权利人:SCINOPHARM TAIWAN LTD
摘要:The present invention provides efficient and economical methods for synthesis of (−)-2-exo-morpholinoisoborne-10-thiol, its enantiomer, and related chiral catalysts. Novel compounds and methods of asymmetric synthesis are also disclosed.

专利号:US-7230119-B2
优先权日:2004-08-25
标 题 :Process for the preparation of substituted pyrrolidine derivatives and intermediates
发明人：CHAND POORAN; EL-KATTAN YAHYA; KOTIAN PRAVIN L
权利人:BIOCRYST PHARM INC
摘要:Two syntheses are provided; one for the preparation of (3R,4R)-4-(hydroxymethyl)pyrrolidin-3-ol, and other for the preparation of (3S,4R)-4-(hydroxymethyl)pyrrolidin-3-ol. (3R,4R)-4-(hydroxymethyl)pyrrolidin-3-ol is prepared using the achiral ylide prepared from benzylamine instead of phenethylamine (Scheme 3) which provides a crystalline intermediate. The synthesis of (3S,4R)-4-(hydroxymethyl)pyrrolidin-3-ol is achieved from (S)-diethylmalate as described in Scheme 4. A process for preparing camphor sultam is also provided.