CAS: 3953-65-9; 2-Chloro-N-Methyl-10H-Phenothiazine-10-Propanamine Hydrochloride

该化合物是一种属于苯并类的化学化合物,其特点是含有硫磺和氮原子的三环结构.该化合物通常具有与该物质脊椎相关的特性,包括潜在的药理活动,特别是作为抗...

英文名称2-Chloro-N-Methyl-10H-Phenothiazine-10-Propanamine Hydrochloride
中文名称去甲基盐酸氯丙嗪
IUPAC名称3-(2-chlorophenothiazin-10-yl)-N-methylpropan-1-amine;hydrochloride
CAS编号3953-65-9
MFCD编号:MFCD01310588
分子式:C16H18Cl2N2S分子量:341.29
产品CID: 1407220
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: HDISSMQVJRSCEK-UHFFFAOYSA-N
1S/C16H17ClN2S.ClH/c1-18-9-4-10-19-13-5-2-3-6-15(13)20-16-8-7-12(17)11-14(16)19;/h2-3,5-8,11,18H,4,9-10H2,1H3;1H
计算化学: 氢键受体数3.0氢键供体数2.0可旋转键数4.0

物理性质

熔点178-180°C
沸点178-180 °C
闪点230.9 °C
PSA:40.57
LogP:5.8101
蒸汽压1.4E-08 mmHg at 25 °C
溶解性Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
外观形态白色至类白色固体
储存条件防潮, -20°C 冰箱, 在惰性气其中

MSDS等安全信息

警示词warning
危险描述H303 May be harmful if swallowed+H313 Skin contact may be harmful+H333 Inhalation may be harmful to the body
防范说明P264+P280+P305+P351+P338+P337+P313
安全声明H303+H313+H333

上下游产品

2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine 2-chlorophenothiazineN-[3-(2-chloro-phenothiazin-10-yl)-propyl]-N-methyl-toluene-4-sulfonamideN-[3-(2-chloro-phenothiazin-10-yl)-propyl]-N-methyl-toluene-4-sulfonamide 2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

合成工艺路线路线简述

📜氯丙嗪以甲醇,1,2-二氯乙烷作为反应溶剂,化学反应 1.75H,反应生成去甲基盐酸氯丙嗪
参考文献:Synthesis Of [n-13Ch3] Drugs (Chlorpromazine,Triflupromazine And Promazine)
标题:Synthesis Of [n-13Ch3] Drugs (Chlorpromazine,Triflupromazine And Promazine)
摘要:These [n-(Ch3)-C-13] Containing Drugs (Chlorpromazine,Triflupromazine And Promazine) Have Been Synthesized By Means Of A Two-Step Demethylation/methylation Procedure.
DOI:10.1002/1099-1344(200008)43:9<865::Aid-Jlcr370>3.0.Co;2-E