CAS: 38989-38-7; Coralyne Chloride

该化合物是属于类藻类的化学化合物,其特点是独特的结构,包括多环框架,有助于其生物活动; 氯化珊瑚以其潜在的药理特性著称,特别是其与可能影响细胞过程的核酸的相互作用.该化合物一般是晶体固体,在各种有机溶剂中溶解.它的活性可归因于存在能够与其他分子互动的功能组.在研究中,对氯化珊瑚进行了研究,以了解其对细胞生长和差异的影响,使其对药用化学和药物开发具有兴趣.然而,与许多化学物质一样,在处理时,应注意安全防范,因为其生物影响可能随浓度和接触而变化.

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    专利号:US-2005202459-A1
    优先权日:2003-09-23
    标 题 :Intercalation-mediated synthesis of polymers

    专利号:US-7368560-B2
    优先权日:2003-09-23
    标题:Intercalation-mediated synthesis of polymers
    发明人:HUD NICHOLAS V
    权利人:GEORGIA TECH RES INST
    摘要:Methods and compositions for synthesizing biopolymers using an intercalator are provided. Aspects provide compositions and methods for synthesizing biopolymers with non-natural backbones or non-natural biopolymer subunits using natural biopolymer templates. Other aspects provide compositions and methods for synthesizing biopolymers using a template with a non-natural backbone on non-natural biopolymer subunits.

    专利号:US-3914424-A
    优先权日:1973-01-30
    标题 :Method for treating P-388 or L-1210 leukemia strains
    发明人:ZEE-CHENG KWANG YUEN; CHENG CHIA-CHUNG
    权利人:US HEALTH
    摘要:A process for the synthesis of coralyne salts and related dehydroberbinium salts. The process includes a phenylacetyl chloride and phenylethylamine condensation, followed by cyclization, aromatization and formation of a dehydroberbinium sulfoacetate, which may thereafter be converted into other dehydroberbinium salts. The coralyne salts have antineoplastic activity.

    专利号:WO-9727206-A1
    优先权日:1996-01-26
    标 题:Oligonucleotide analogs
    发明人:KHORLIN ALEXANDER A; WATANABE KYOICHI A
    权利人:CODON PHARMACEUTICALS INC
    摘要:Macromolecules are disclosed which contain the structure (1) wherein the substituents are defined in the specification. Also disclosed are compounds useful in the synthesis of the above compounds, as well as pharmaceutical compositions containing the above compounds as an active ingredient.

    专利号:US-2003198960-A1
    优先权日:2002-04-01
    标 题 :Signal amplifying targeted reporters for biological and chemical sensor applications
    发明人:FAN WENHONG; LI JUN; HAN JIE
    摘要:The present invention provides targeted dendrimeric reporter molecules that provide amplified signals at electrochemical sensors, and methods of synthesis and methods of use thereof. The reporter molecules comprise a targeting moiety and at least one dendritic signal amplifier; the dendritic amplifier comprises a plurality of dendritic branches and a plurality of indicator moieties, typically pendant therefrom. The targeting moiety serves to concentrate the dendritic amplifier at a selected target, where the plural indicator provide increased signals.

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    主要参考文献


    1: Padmapriya K, Barthwal R. Nuclear magnetic resonance based structure of the protoberberine alkaloid coralyne and its self-association by spectroscopy techniques. J Pharm Anal. 2019 Dec;9(6):437-448. doi: 10.1016/j.jpha.2019.09.006. Epub 2019 Sep 26.
    2: Ma C, Chen M, He H, Chen L. Detection of coralyne and heparin by polymerase extension reaction using SYBR Green I. Mol Cell Probes. 2019 Aug;46:101423. doi: 10.1016/j.mcp.2019.101423. Epub 2019 Jul 16. 120(10):18104-18116. doi: 10.1002/jcb.29114. Epub 2019 Jun 6.
    194:140-148. doi: 10.1016/j.jphotobiol.2019.03.011. Epub 2019 Mar 21.

    合成参考文献


    摘要:National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program., JAN1986
    参考文献:10.1186/s12888-018-1703-1
    摘要:Hancock N, Smith-Merry J, Jessup G, Wayland S, Kokany A. Understanding the ups and downs of living well: the voices of people experiencing early mental health recovery. BMC Psychiatry. 2018 May 04;18(1):121.
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