CAS: 328-87-0; 2-Chloro-5-Trifluoromethylbenzonitrile

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2-氯-5-三氟甲基苯甲醛置于hcl.dmpu,盐酸羟胺体系中,用 乙腈 用作溶剂,以98%的收率获得2-氯-5-三氟甲基苯腈
参考文献:Hcl.dmpu辅助的一锅无醛醛转化为腈
标题:Hcl.dmpu辅助的一锅无醛醛转化为腈
摘要:我们报告了一种有效的hcl.dmpu辅助将一锅法将醛转化为腈的方法.将hcl.dmpu用作酸性来源和非亲核碱均构成制备腈的环境温和的替代方法.我们的操作规程顺利进行,无需使用有毒的试剂和金属催化剂.结合了各种官能团的各种官能化的芳香族,脂肪族和烯丙基醛已成功地以优异的定量转化为腈.该协议的特点是底物范围广,反应条件温和,可扩展性高.
Doi:10.1039/d0Gc00757A

专利信息

专利号:WO-2013091696-A1
优先权日:2011-12-21
标题 :Synthesis of intermediates for preparing anacetrapib and derivatives thereof
发明人：HUMLJAN JAN; MARAS NENAD
权利人:LEK PHARMACEUTICALS; HUMLJAN JAN; MARAS NENAD
摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.

专利号:EP-2468735-A1
优先权日:2010-12-23
标 题:Synthesis of intermediates for preparing anacetrapib and derivates thereof
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.

专利号:US-9212118-B2
优先权日:2010-12-23
标题:Synthesis of intermediates for preparing anacetrapib and derivatives thereof
发明人：HUMLJAN JAN; MARAS NENAD
权利人:HUMLJAN JAN; MARAS NENAD; LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.

专利号:US-4822903-A
优先权日:1981-05-15
标题:Fluorinated silica catalyst and preparation of aromatic/aliphatic nitriles in the presence thereof
发明人：JACQUES ROLAND; REPPELIN MICHEL; SEIGNEURIN LAURENT
权利人:RHONE POULENC SPEC CHIM
摘要:An improved fluorinated siliceous catalyst, well adapted for the catalytic synthesis of aromatic/aliphatic nitriles from their corresponding formamides, formanilides or amides, is comprised of a plurality of silica particulates, the specific surface of which ranging from about 200 to about 300 m 2 /g, having a total pore volume ranging from about 1 to about 1.5 cm 3 /g, with an average pore diameter ranging from about 100 to about 200 â„«, having an exchange pH of less than about 3, and with the fluorine content thereof bonded to the silica, expressed in F 31 , ranging from about 0.05 to about 2% by weight based upon the silica, and the sodium content thereof, expressed as Na 2 O, being less than about 1% by weight, also based upon the silica.

专利号:WO-2012085133-A1
优先权日:2010-12-23
标 题:Synthesis of intermediates for preparing anacetrapib and derivatives thereof

专利号:US-2014135368-A1
优先权日:2010-12-23
标题 :Synthesis of intermediates for preparing anacetrapib and derivatives thereof