CAS: 301305-73-7; 2-(3,4-Dimethoxybenzamido)-4,5,6,7-Tetrahydrobenzo[b]Thiophene-3-Carboxamide

上下游产品

2-氨基-4,5,6,7-四氢苯并[b]噻吩-3-甲酰胺 2-Amino-4,5,6,7-Tetrahydrobenzo[b]Thiophene-3-Carboxamide 4815-28-5

📜3,4-二甲氧基苯甲酰氯,2-氨基-4,5,6,7-四氢苯并[b]噻吩-3-甲酰胺置于n,N-二异丙基乙胺体系中,用 四氢呋喃 用作溶剂,化学反应 2.0H,反应生成2-[(3,4-二甲氧基苯甲酰基)氨基]-4,5,6,7-四氢-苯并[b]噻吩-3-甲酰胺
参考文献:Identification Of 2-Acylaminothiophene-3-Carboxamides As Potent Inhibitors Of Flt3
标题:Identification Of 2-Acylaminothiophene-3-Carboxamides As Potent Inhibitors Of Flt3
摘要:A Series Of 2-Acylaminothiophene-3-Carboxamides Has Been Identified Which Exhibit Potent Inhibitory Activity Against The Flt3 Tyrosine Kinase. Compound 44 Inhibits The Isolated Enzyme (Ic50 = 0.027 Mu M) And Blocks The Proliferation Of Mv4-11 Cells (Ic50 = 0.41 Mu M). Structure Activity Relationship Studies Within This Series Are Described In The Context Of A Proposed Binding Model Within The Atp Binding Site Of The Enzyme. (C) 2006 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2006.03.032

专利信息

专利号:US-2019031650-A1
优先权日:2016-01-29
标 题 :Dna alkylation and cross-linking agents as compounds and payloads for targeted therapies
发明人：HERZON SETH; HEALY ALAN; CRAWFORD JASON; VIZCAINO MARIA; NIKOLAYEVSKIY HERMAN
权利人:UNIV YALE
摘要:The present invention is directed to compounds related to precolibactin pharmaceutical compositions based upon these compounds and methods of synthesis which are employed to provide intermediates and final compounds, which are principally alkylating agents and anticancer compounds. The chemical synthetic approach disclosed facilitates the synthesis of numerous precolibactin analogs which can be used in the treatment of cancer.