CAS: 2870-71-5; Endo-3-((3-Hydroxy-2-Phenylpropanoyl)Oxy)-8,8-Dimethyl-8-Azabicyclo[3.2.1]Octan-8-Ium Bromide

该化合物是来自阿托品的一种四铵化合物,是一种自然产生的藻类,其特点是它能够作为抗胆碱基剂,主要作为肌肉癌性乙酰胆碱酯酶受体的竞争性对抗者发挥作用;该化合物通常用于药理应用,特别是用于治疗诸如胸膜心肌等各种病症和减少外科手术过程中的唾液;阿托品甲基溴因其在水中的溶液性相对高于其母体,即阿托品而闻名,这增加了其生物利用率;该化合物具有一系列生理影响,包括心率提高和呼吸道分泌减少,但也可能造成副作用,如口干,视力模糊和因其抗胆碱性特性而保留尿.与许多药剂一样,谨慎的剂量和监测对于减轻潜在不利影响至关重要.

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物理性质

MSDS等安全信息

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CAS号74-83-9 溴甲烷 | CAS号51-55-8 阿托品； 颠茄碱

合成工艺路线路线简述

    📜溴甲烷,Atropine 在 氯仿体系中,获得 (8,8-Dimethyl-8-Azoniabicyclo[3.2.1]octan-3-yl) 3-Hydroxy-2-Phenylpropanoate,Bromide
    参考文献:Malpass,American Journal Of Pharmacy And The Sciences Supporting Public Health (1937-1978),1951,Vol. 123,P. 5,8
    标题:Malpass,American Journal Of Pharmacy And The Sciences Supporting Public Health (1937-1978),1951,Vol. 123,P. 5,8

    海关参考信息

    专利信息


    专利号:US-2007059711-A1
    优先权日:2004-07-30
    标 题:Microarray for evaluation of stress-related genes in skin
    发明人：SLOMINSKI ANDRZEJ; PISARCHIK ALEXANDER
    权利人:SLOMINSKI ANDRZEJ; PISARCHIK ALEXANDER
    摘要:The present invention provides a novel DNA microarray chip that can be used for simultaneous testing of transcriptional responses to cutaneous stressors in the context of neuro-endocrine-immune functions of the skin. The transcriptional responses to ultraviolet radiation in epidermal keratinocytes were tested using such microarray chip containing more than 700 neuro-endocrine-immune related genes. The gene expression pattern was non-random and time dependent; it included increased expression of genes involved in water and salt balance, prostaglandin synthesis, keratinocyte differentiation as well as genes coding for stress effectors, cytokines and metalloproteinases. In contrast, expression was decreased for genes coding for growth factors and their receptors, and for elements of extracellular matrix. This stochastic pattern suggests that transcriptional responses are coordinated and aimed at preservation of epidermal barrier function, prevention of early carcinogenic events and remodeling of extracellular matrix.

    专利号:KR-20190134130-A
    优先权日:2018-05-25
    标题 :Novel composition useful for prevention or treatment of dementia by inhibiting synthesis of β-amyloid

    专利号:RU-2183631-C2
    优先权日:2000-09-20
    标题 :Method of synthesis of indole-3-carboxylic acid 8-methyl-8- azabicyclo[3,2,1]oct-3-yl ester

    专利号:WO-2012051173-A2
    优先权日:2010-10-14
    标 题:A method for promoting the synthesis of collagen and proteoglycan in chondrocytes

    专利号:ES-2374981-T3
    优先权日:2001-06-28
    标 题:TECHNICAL SYNTHESIS PROCEDURE FOR THE PREPARATION OF PROPENOL.

    专利号:CN-115369440-A
    优先权日:2022-06-02
    标 题:A kind of H-CNTs material for high selectivity H2O2 synthesis and preparation method thereof

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    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Silva LEV, Geraldini VR, de Oliveira BP, Silva CAA, Porta A, Fazan R. Comparison between spectral analysis and symbolic dynamics for heart rate variability analysis in the rat. Sci Rep. 2017 Aug 16;7(1):8428. doi: 10.1038/s41598-017-08888-w.
    2: Santos-Almeida FM, Domingos-Souza G, Meschiari CA, Fávaro LC, Becari C, Castania JA, Lopes A, Cunha TM, Moraes DJA, Cunha FQ, Ulloa L, Kanashiro A, Tezini GCSV, Salgado HC. Carotid sinus nerve electrical stimulation in conscious rats attenuates systemic inflammation via chemoreceptor activation. Sci Rep. 2017 Jul 24;7(1):6265. doi: 10.1038/s41598-017-06703-0.
    3: Magagna-Poveda A, Moretto JN, Scharfman HE. Increased gyrification and aberrant adult neurogenesis of the dentate gyrus in adult rats. Brain Struct Funct. 2017 Dec;222(9):4219-4237. doi: 10.1007/s00429-017-1457-4. Epub 2017 Jun 27.

    合成参考文献


    摘要:Archives Internationales de Pharmacodynamie et de Therapie., 180(155), 1969 []
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