CAS: 24629-25-2; (2S,3S)-2-Amino-3-Methylpentan-1-Ol

相似化合物

106946-74-1 133736-94-4 4379-13-9

上下游产品

CAS号73-32-5 L-异亮氨酸 | CAS号2577-46-0 L-异亮氨酸甲酯 | CAS号921-74-4 ethyl L-isoleucinate

L-异亮氨酸置于sodium Tetrahydroborate,碘体系中,用 四氢呋喃 用作溶剂,化学反应生成L-异亮氨醇
参考文献:Dabco催化各种亲核试剂与活化炔烃的反应,导致形成烯酸酯,1,4-二恶烷,吗啉和哌嗪酮衍生物
标题:Dabco催化各种亲核试剂与活化炔烃的反应,导致形成烯酸酯,1,4-二恶烷,吗啉和哌嗪酮衍生物
摘要:系统地研究了酸,醇,酰基酰胺,1,2-二醇,1,2-二胺或氨基醇与1,4-二氮杂双环[2.2.2]辛烷(dabco)催化的炔烃的反应.在一元或二元亲核试剂的反应中,分别以优异的收率形成了一系列不饱和链烯酸酯或杂环.
Doi:10.1016/j.Tet.2006.04.100

专利信息

专利号:US-6423871-B1
优先权日:1999-02-26
标题 :Efficient synthesis of secondary amines by selective alkylation of primary amines
发明人：JUNG KYUNG WOON
权利人:UNIV SOUTH FLORIDA
摘要:A method for selective mono-N-alkylation of primary amines to produce secondary amines that are substantially free of overalkylated tertiary amines and quaternary ammonium salts, under mild reaction conditions without the necessity of protecting groups. Compounds of the class of secondary amines are produced by reacting an alkyl halide with an alkyl amine in anhydrous solvent, preferably dimethyl sulfoxide or N,N-dimethylformamide, in the presence of 0.1 to 3 molar equivalents of a cesium base. Optionally, the extent and selectivity of mono-N-alkylation is enhanced by addition to the reaction mixture of a powdered molecular sieve material for removal of water produced by the reaction, and/or tetrabutylammonium iodide to promote halide exchange. The invention permits selective and efficient mono-N-alkylation of a wide variety of substrates at 23° C.; does not cause racemization when used with enantiomerically-pure chiral substrates such as L-α-aminoesters; and is applied to solid phase synthesis whereby either the alkyl amine or alkyl halide is immobilized. The method is additionally used to produce polyamines, such as N-(2-(2-aminoethylthio)ethyl)ethylenediamine in 73% yield.

专利号:US-2020384451-A1
优先权日:2017-09-05
标题:Phosphine free cobalt based catalyst, process for preparation and use thereof
发明人：BALARAMAN EKAMBARAM; MIDYA SIBA PRASAD; LANDGE VINOD GOKULKRISHNA
权利人:COUNCIL SCIENT IND RES
摘要:The present invention discloses a phosphine free cobalt based catalyst of formula (I) and a process for preparation thereof. The present invention further discloses a process for the synthesis of aromatic heterocyclic compounds of formula (II) and pyrazine derivative using the phosphine free cobalt based catalyst of formula (I).

专利号:US-7659244-B2
优先权日:2003-11-03
标题:Rapamycin peptides conjugates: synthesis and uses thereof
发明人：SHARMA SANJAY K; WOO THOMAS; NAICKER SELVARAJ
权利人:QUEST PHARMATECH INC
摘要:The present invention relates to new rapamycin derivatives for the inhibition of cell proliferation. The compounds can advantageously target two proteins in dividing cells and interfere with cell cycle. There is thus provided derivatives of rapamycin in which the 42 position of rapamycin is linked to an amino acid or a peptide through a carbamate ester linkage. These rapamycin derivatives can be synthesized by reacting 42-O-(4-Nitrophenoxycarbonyl) rapamycin and an amino acid or a free amino peptide under basic conditions. These rapamycin derivatives can be used to inhibit the cell cycle and are therefore useful for treating cell proliferation disorders.

专利号:US-5378690-A
优先权日:1986-12-19
标题 :New renin-inhibitory oligopeptides, their preparation and their use
发明人：MORISAWA YASUHIRO; KATAOKA MITSURU; YABE YUICHIRO; IIJIMA YASUTERU; TAKAHAGI HIDEKUNI; KOIKE HIROYUKI; KOKUBU TATSUO; HIWADA KUNIO
权利人:SANKYO CO
摘要:Oligopeptides of formula (I): (I) where R1-R5 are various organic groups, and A represents a group of formula -NH- or -(CH2)n-, in which n represents an integer of from 1 to 3, have renin-inhibitory activity and are particularly suitable for oral administration. They may be prepared by condensing their component amino acids or lower oligopeptides using conventional peptide synthesis reactions.