专利号:WO-2012047907-A9 优先权日:2010-10-04 标题 :Synthesis of c5-substituted tetracyclines, uses thereof, and intermediates thereto 发明人:MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN 权利人:HARVARD COLLEGE; MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN 摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for a wide variety of substituents at position 5 of the tetracycline ring system.
专利号:US-4855425-A 优先权日:1986-08-27 标题:Process for the selective synthesis of ethylene diamines 发明人:MARSELLA JOHN A 权利人:AIR PROD & CHEM 摘要:The present invention is a process for the selective synthesis of alkanediamines by reacting a secondary amine with an alkanediol. High conversions and high selectivity for the production of alkanediamines is achieved by carrying out the reaction in the presence of a compound or complex of ruthenium in the absence of an organic phosphine co-catalyst.
专利号:US-2007260089-A1 优先权日:2004-03-26 标 题 :Method for the Synthesis of Quaternary Ammonium Compounds and Compositions Thereof 发明人:SAUER JOE D; KNIGHT CHRISTOPHER S; EVERLY CHARLES R; CHENG CHI HUNG 权利人:ALBEMARLE CORP 摘要:A novel manufacturing process is described for producing quaternary ammonium compounds having a selected anion, which may be useful in wood preservative formulations. The process involves reacting a trialkylamine with an alkyl bromide to form a quaternary tetraalkylammonium bromide salt, converting the quaternary tetraalkylammonium bromide salt to a quaternary tetraalkylammonium hydroxide salt by using an ion exchange resin, and converting the quaternary tetraalkylammonium hydroxide salt to the quaternary tetraalkylammonium salt of the selected anion.
专利号:US-4745190-A 优先权日:1984-07-25 标 题 :Selective synthesis of substituted amines 发明人:MARSELLA JOHN A 权利人:AIR PROD & CHEM 摘要:Selective mono- or di-amination of alkanediols is controllably obtained by catalytic reaction with secondary amines at moderate temperature and autogenous pressure, by selection of the catalyst employed. Ruthenium complexes compounded or admixed with selected organic phosphines, such as triphenylphosphine, favor high yields of alkanolamines, while ruthenium complexes in the absence of organic phosphines favor production of alkylenediamines. Iridium complexes with or without organic phosphines in admixture or chemical combination, also promote production of alkylenediamines.
专利号:US-7956214-B2 优先权日:2001-11-02 标题 :Process for the preparation of aniline-derived thyroid receptor ligands 发明人:CHIDAMBARAM RAMAKRISHNAN; KANT JOYDEEP; WEAVER RAYMOND E; YU JURONG; GHOSH ARUN 权利人:KAROBIO AB; BRISTOL MYERS SQUIBB CO 摘要:Provided are processes for the synthesis of aniline derivatives, specifically certain aniline derivatives which have activity as thyroid receptor ligands.
专利号:US-5457233-A 优先权日:1992-09-11 标 题 :Process for the preparation of amines 发明人:OUZIEL PHILIPPE 权利人:CIBA GEIGY CORP 摘要:A process for the preparation of amines of formula (1) wherein the variables are defined as in the claims, which comprises reacting 1 molar equivalent of an amine of formula (2) with 0.8 to 1.5 molar equivalents of an aldehyde of formula R-CHO(3) and 0.8 to 2 molar equivalents of formic acid, in aqueous medium, and adjusting the pH by addition of a mineral acid such that, at the conclusion of the reaction, the pH is in the range from 3 to 7. The compounds obtainable by the process are useful intermediates for the synthesis of dyeing assistants.