CAS: 22385-36-0; 6-Methoxypyridin-2(1H)-One

该化合物是一种七环有机化合物,在6号位置用甲氧基组替代了一条丙烯酮核心,该化合物是有机合成的多用途中间体,特别是在制药,农用化学品和特殊化学制品的制作方面.其结构图案对于建造复杂的分子很有价值,因为丙烯酮环和刺激电子的甲氧基组体具有反应性.该化合物在标准条件下表现出稳定性,便于处理和储存.其应用包括将药用化学用作开发生物活性化合物的建筑块,其功能组群可以进一步衍生.高纯度等级可以满足严格的研究和工业要求.

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1261598-78-0 10357-84-3 4664-16-8

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CAS号108279-32-9 2-benzyloxy-6-m... | CAS号2402-78-0 2,6-二氯吡啶 | CAS号17228-64-7 2-氯-6-甲氧基吡啶 | CAS号52545-13-8 无中文名(订作4-5周) | CAS号22385-36-0 2-羟基-6-甲氧基吡啶 | CAS号22385-36-0 2-羟基-6-甲氧基吡啶

合成工艺路线路线简述

    📜2,6-二氯吡啶置于palladium On Activated Charcoal 氢气,Sodium体系中,用 甲醇 用作溶剂,化学反应 7.0H,反应生成2-羟基-6-甲氧基吡啶
    参考文献:Kaneko,Chikara; Uchiyama,Keiji; Sato,Masayuki,Chemical And Pharmaceutical Bulletin,1986,Vol. 34,# 9,P. 3658-3671
    标题:Kaneko,Chikara; Uchiyama,Keiji; Sato,Masayuki,Chemical And Pharmaceutical Bulletin,1986,Vol. 34,# 9,P. 3658-3671

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    专利信息


    专利号:US-2023174567-A1
    优先权日:2020-05-22
    标题:Synthesis of fluorinated nucleotides
    发明人：ARMIGER TRAVIS; BELYK KEVIN M; BENKOVICS TAMAS; CHUNG CHEOL K; JI CHEN YINING; JOHNSON HEATHER CLAIRE; KLAPARS ARTIS; LIU ZHIJIAN; LIU ZHUQING; MOORE JEFFREY C; NEEL ANDREW J; PENG FENG; RUMMELT STEPHAN M; SALEHI MARZUARANI NASTARAN; SHERRY BENJAMIN D; SONG ZHIGUO JAKE; TURNBULL BEN WILLIAM HULME; WANG LU; XU FENG
    权利人:MERCK SHARP & DOHME LLC
    摘要:The present invention relates to efficient processes useful in the preparation of fluorinated nucleosides, such as (2S,3R,4S,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-fluoro-4-hydroxy-2-(mercaptomethyl)tetrahydrofuran-3-yl dihydrogen phosphate, also known as 3′-fluoro-thio-guanosine monophosphate or 3′-F-thio-GMP. Such fluorinated nucleosides may be useful as a biologically active compound and or as an intermediate for the synthesis of more complex biologically active compounds. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation. (I)

    专利号:WO-2021236859-A1
    优先权日:2020-05-22
    标题 :Synthesis of fluorinated nucleotides

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    合成参考文献


    摘要:A.R. Katritzky, F.D. Popp and J.D. Rowe. J. Chem. Soc., B 1966, 562.
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