CAS: 2142-63-4; 3'-Bromoacetophenone

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134615-22-8 134615-24-0 52780-14-0

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CAS号52780-14-0 3-溴-Alpha-甲基苯甲醇 | CAS号98-86-2 苯乙酮 | CAS号2725-82-8 3-溴乙基苯 | CAS号585-76-2 3-溴苯甲酸 | CAS号917-54-4 甲基锂 | CAS号127-19-5 N,N-二甲基乙酰胺(DMAC) | CAS号108-36-1 1,3-二溴苯 | CAS号99-03-6 3'-氨基苯乙酮 | CAS号24280-05-5 1-(3-bromopheny... | CAS号78191-00-1 N-甲氧基-N-甲基乙酰胺 | CAS号106052-24-8 (3-乙酰基苯基)-磷酸二乙酯 | CAS号74-96-4 溴乙烷 | CAS号49839-81-8 2-(3-溴苯基)-2-羟基乙酸 | CAS号35065-86-2 3-溴乙酸苯酯 | CAS号52780-14-0 3-溴-Alpha-甲基苯甲醇 | CAS号67-64-1 丙酮 | CAS号349-76-8 间三氟甲基苯乙酮 | CAS号3972-64-3 1-溴-3-叔丁基苯 | CAS号39910-98-0 4-吗啉基苯丙酮 | CAS号182169-63-7 1-(4-甲氧基[1,1-联苯...

苯乙酮置于trans-3,5-Dihydroperoxy-3,5-Dimethyl-1,2-Dioxolane,溴化铵体系中,用 水 用作溶剂,以90 %的收率获得3'-溴苯乙酮
参考文献:温和条件下反式-3,5-二氢过氧-3,5-二甲基-1,2-二氧戊环促进非反应性芳香族底物在水中的氧化溴化
标题:温和条件下反式-3,5-二氢过氧-3,5-二甲基-1,2-二氧戊环促进非反应性芳香族底物在水中的氧化溴化
摘要:发表于<国际有机制备和程序:有机合成新期刊>(第 56 卷,第 1 期,2024 年)
Doi:10.1080/00304948.2023.2219199

专利信息

专利号:WO-2008054857-A1
优先权日:2006-11-01
标 题:Process for the preparation of intermediates useful in the treatment of hiv infection
发明人：MARTIN MICHAEL TOLAR
权利人:SMITHKLINE BEECHAM CORP; MARTIN MICHAEL TOLAR
摘要:The present invention is directed to processes for the synthesis of intermediates useful in the preparation of non-nucleoside reverse transcriptase inhibitors.

专利号:US-8962839-B2
优先权日:2010-11-19
标题:Chiral spiro-pyridylamidophosphine ligand compound, synthesis method therefor and application thereof
发明人：ZHOU QILIN; XIE JIANHUA; LIU XIAOYAN; XIE JIANBO; WANG LIXIN
权利人:ZHOU QILIN; XIE JIANHUA; LIU XIAOYAN; XIE JIANBO; WANG LIXIN; ZHEJIANG JIUZHOU PHARMA SCIENCE & TECHNOLOGY CO LTD
摘要:The present invention relates to a chiral spiro-pyridylamidophosphine ligand compound, synthesis method therefor and application thereof. The chiral spiro-pyridylamidophosphine compound is a compound having a structure of Formula (I), a racemate or optical isomer thereof, or a catalytically acceptable salt thereof, and is mainly characterized by having a chiral spiro-dihydro-indene skeleton in its structure. The chiral spiro-pyridylamidophosphine compound may be synthesized with optical active 7-diaryl/alkylphosphino-7′-amino-1,1′-spiro-dihydro-indene or substituted 7-diaryl/alkylphosphino-7′-amino-1,1′-spiro-dihydro-indene having a spiro-skeleton as chiral starting material. The chiral spiro-pyridylamidophosphine compound may be used as a chiral ligand in asymmetric hydrogenation of a carbonyl compound catalyzed by iridium, in which the reaction activity is very high, the amount of the catalyst may be 0.0001 mol %, and the enantioselectivity of the reaction is up to 99.9% ee.

专利号:US-2007128658-A1
优先权日:2005-11-14
标 题:Fluorescent dyes, methods and uses thereof
发明人：BLACKWELL HELEN E; BOWMAN MATTHEW D
权利人:BLACKWELL HELEN E; BOWMAN MATTHEW D
摘要:The present invention provides a method for identifying and characterizing candidate fluorescent molecules. This method involves the generation of spatially addressed arrays of heterocyclic compounds which are candidate fluorescent molecules. The spatially addressed array can be used to identify fluorescent molecules among the candidate molecules. The spatially addressed array can be used to determine the optical characteristics of one more candidate molecules. The invention also provides methods for making such arrays of heterocyclic compounds. In a specific embodiment, synthetic methods are provided for synthesis of triarylpyridines, particularly unsymmetric triarylpyridines. n preferred embodiments, the present invention provides novel heterocyclic fluorescent compounds having deazalumazine, cyanopyridine or pyrimidine cores. Heterocyclic fluorescent compounds of this invention are useful as dyes to label molecules such as nucleic acids, peptides and proteins, and particularly antibodies. In other embodiments, the novel heterocyclic fluorescent compounds are useful as dyes to label cellular compartments and organelles. The novel heterocyclic fluorescent compounds can also be used as sensors or indicators of specific metal ions, chemical warfare agents and pH.

专利号:US-6114489-A
优先权日:1997-03-27
标 题 :Reactive hyperbranched polymers for powder coatings
发明人：VICARI RICHARD; FRUCHEY OLAN STANLEY; JUNEAU KATHLEEN NELSON; THAMES SHELBY FRELAND; RAWLINS JAMES WAYNE
权利人:HERBERTS GMBH
摘要:Novel powder coating compositions containing reactive hyperbranched polymers are disclosed and claimed. Preferred embodiments include powder coating compositions formed from hyperbranched polyesters having terminal hydroxy, carboxy, epoxy, and isocyanate groups. Preferred hyperbranched polyesters are formed from alpha , alpha -bis-(hydroxymethyl)-propionic acid, which act either as crosslinkers, adhesion promotors, or flow and leveling agents. A process for the synthesis of powder coating compositions is also disclosed which involves (a) self condensation of one or more of the multifunctional monomers to form the hyperbranched polymer, optionally, in the presence of suitable reactive end-capping moieties which are described herein; (b) melt blending of the hyperbranched polymer with suitable amounts of one or more of polyesters, epoxy resins, blocked urethane resins, or acrylic resins, a crosslinker, and one or more of suitable additional ingredients including degassers or flow and leveling agents, to form a flake; and (c) grinding and sieving of the flake to form the powder coating composition. These compositions exhibit improved flow and curing properties. These compositions can therefore be formed into thin films and can be cured at low temperatures to form smooth surfaces. Additionally, these films are hard and exhibit enhanced impact resistance properties than the conventional polyester resins. Thus, these powder coating compositions find utilities in automotive, packaging, and appliances.

专利号:US-8338451-B2
优先权日:2008-03-21
标 题 :Polysubstituted derivatives of 2-heteroaryl-6-phenylimidazo[1,2-a]pyridines, and preparation and therapeutic use thereof
发明人：DE PERETTI DANIELLE; EVANNO YANNICK; LARDENOIS PATRICK; MACHNIK DAVID; RAKOTOARISOA NATHALIE; ALMARIO GARCIA ANTONIO
权利人:DE PERETTI DANIELLE; EVANNO YANNICK; LARDENOIS PATRICK; MACHNIK DAVID; RAKOTOARISOA NATHALIE; ALMARIO GARCIA ANTONIO; SANOFI SA
摘要:Compounds of formula (I): n nwherein R, R 1 , R 2 , R 3 , R 4 and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof.

专利号:US-8853228-B2
优先权日:2007-06-04
标 题:Heterocyclic analogs of propargyl-linked inhibitors of dihydrofolate reductase
发明人：ANDERSON AMY C; WRIGHT DENNIS L; FREY KATHLEEN MARY; PAULSEN JANET LEIGH; SCOCCHERA ERIC WILLIAM; VISWANATHAN KISHORE
权利人:ANDERSON AMY C; WRIGHT DENNIS L; FREY KATHLEEN MARY; PAULSEN JANET LEIGH; SCOCCHERA ERIC WILLIAM; VISWANATHAN KISHORE; UNIV CONNECTICUT
摘要:The compositions and methods described herein disclose the design, synthesis and testing of compounds that act as inhibitors of DHFR. The basic scaffold of these inhibitors includes a 2,4-diaminopyrimidine ring with a propargyl linker to another substituted aryl, bicyclo or heteroaryl ring. These DHFR inhibitors are potent and selective for many different pathogenic organisms, including the DHFR enzyme from bacteria such as Bacillus anthracis and methicillin-resistant Staphylococcus aureus , fungi such as Candida glabrata, Candida albicans and Cryptococcus neoformans and protozoa such as Cryptosporidium hominis and Toxoplasma gondii . These compounds and other similar compounds are also potent against the mammalian enzyme and may be useful as anti-cancer therapeutics.