专利号:US-10391166-B2 优先权日:2013-02-18 标 题:Short oligonucleotides as vaccine adjuvants and therapeutic agents 发明人:IYER RADHAKRISHNAN P 权利人:SPRING BANK PHARMACEUTICALS INC; SPRING BREAK PHARMACEUTICALS INC 摘要:The invention provides a method of treating a microbial infection in a subject and a method of improving an immune system response in a subject against a disease, condition, infection, or virus thereof, by administering an effective amount of a nucleoside, short oligonucleotide compound or an analog thereof, or a pharmaceutically acceptable salt, racemate, enantiomer, diastereomer, geometric isomer, or tautomer thereof. In addition, the invention provides methods for treating or preventing a viral infection, bacterial infection, parasitic infection, or fungal infection in a subject (such as, a human). The compounds of the invention include, for example, di-, and trinucleotide compounds as provided herein. The compounds of the invention are useful for different therapeutic applications including, such as, prophylactics and therapeutics. The invention also provides design and synthesis of a compound that is useful for various therapeutic applications as mentioned herein.
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