CAS: 2002-02-0; 4-Oxopyrrolidine-2-Carboxylic Acid

相似化合物

64187-47-9 84348-37-8 364077-84-9

上下游产品

rac-4-oxo-1,2-pyrrolidinedicarboxylic acid diethyl ester

📜Rac-4-Oxo-1,2-Pyrrolidinedicarboxylic Acid Diethyl Ester置于氢碘酸,汞体系中,化学反应生成4-氧代脯氨酸
参考文献:Kuhn; Osswald,Chemische Berichte,1956,Vol. 89,P. 1423,1436
标题:Kuhn; Osswald,Chemische Berichte,1956,Vol. 89,P. 1423,1436

专利信息

专利号:WO-2017021378-A1
优先权日:2015-08-03
标题:Process for the synthesis of protected 4-keto-proline
发明人：BETTONI PIERGIORGIO; GOBBATO STEFANO; VERONESE MARTINO; ROLETTO JACOPO; PAISSONI PAOLO
权利人:PROCOS SPA
摘要:Disclosed is a process for the synthesis of N-protected 4-keto-prolines (1), starting with the corresponding protected 4-hydroxyproline, in the presence of the oxidising system P 2 O 5 /dimethylsulphoxide (DMSO). Said process can also be applied in the presence of a chiral centre in the position bearing carboxylic acid (the 3 position) without significant epimerisation of said centre. Said process is particularly advantageous from the environmental standpoint and in terms of yields, productivity and the purity of the product obtained, since it does not use chromium-based oxidants, metals such as ruthenium, or oxidising systems which are precursors of genotoxic impurities.

专利号:US-9475837-B2
优先权日:2011-12-23
标题 :Process for the synthesis of therapeutic peptides
发明人：HURLEY FIONN; WEGNER KATARZYNA; FOLEY PATRICK
权利人:IPSEN MFG IRELAND LTD
摘要:The present invention relates to a process for the large-scale synthesis of therapeutic peptides using a Sieber Amide resin, which comprises solid-phase Fmoc-chemistry.

专利号:US-2023212788-A1
优先权日:2020-03-26
标 题:New method for automated on-demand biomolecular array synthesis
发明人：ZHANG YIXIN; LIN WEILIN
权利人:UNIV DRESDEN TECH
摘要:The invention provides an amphiphilic coating for the direct and rapid synthesis of an array of peptides and small molecular compounds on a planar surface of a solid support, comprising a hydrophilic chemical structure and a lipophilic group, wherein said peptides and small molecular compounds differ from spot to spot from each other in the chemical structure, characterized in that said amphiphilic coating possesses low wettability to polar aprotic solvents used in the array synthesis; said amphiphilic coating possessing low wettability is designed that it can be converted to a coating possessing high wettability by hydrolysis of the lipophilic group; and said amphiphilic coating comprises an amino group for the reaction with an electrophilic reagent. The invention further provides a solid support comprising said amphiphilic coating and a method for method for the direct and rapid synthesis of an array of peptides and small molecular compounds on a planar surface of a solid support, wherein said planar surface of a solid support comprises said amphiphilic coating. Said method includes the enhancing of the wettability of a glass surface to organic solvents to realize automated on-demand biomolecular array synthesis comprising both, peptides and small molecular compounds. The amphiphilic surface can be switched to a hydrophilic surface, resulting in high density arrays suitable for protein- and cell-based screening.

专利号:US-2024124938-A1
优先权日:2019-10-16
标题:Visual detection of pbd induced dna crosslinks
发明人：LACHAUD CHRISTOPHE; COMBES SÉBASTIEN; ABEL SÉBASTIEN; AUDOLY GILLES; BERRADA SARA
权利人:INST NAT SANTE RECH MED; INST JEAN PAOLI & IRENE CALMETTES; AIX MARSEILLE UNIV; CENTRE NAT RECH SCIENT
摘要:The present invention relates to the field of oncology. laboratory tools and methods, and especially anti-tumor DNA crosslinking agents. Most patients with advanced solid tumors develop resistance to chemotherapy due to the ability of cancer cells to repair or tolerate sustained DNA damages. The inventors showed that the compounds according to the present invention allow the detection and visualization of alkylated DNA damages induced by PBDs without altering their DNA crosslinking ability. This enables the study of the effect and properties of PBDs. In particular, the present invention relates new derivates of PBD molecules and their synthesis. The present invention also relates to a method for visualizing DNA crosslinking: to a method for assessing the resistance of a tumor to a crosslinking agent and to a method for identifying a molecule or treatment for improving the efficiency of a crosslinking agent.

专利号:EA-014248-B1
优先权日:2005-03-03
标 题 :PYROGLUTAMATS AND THEIR APPLICATION FOR THE SEPARATION OF OPTICAL ISOMERS OF INTERMEDIATE PRODUCTS OF SYNTHESIS OF DEXSTROCETHIRISIN AND LEVOCETIRISIN

专利号:CN-115698714-A
优先权日:2020-03-26
标题 :New method for automated on-demand synthesis of biomolecular arrays