CAS: 1640294-30-9; (6-(1-((6-Methoxypyridin-3-yl)Methyl)Piperidin-4-yl)-1H-Benzo[d]Imidazol-2-yl)(4-(4-(Trifluoromethyl)Benzyl)Piperazin-1-yl)Methanone Bis(4-Methylbenzenesulfonate)
- 英文名称(6-(1-((6-Methoxypyridin-3-yl)Methyl)Piperidin-4-yl)-1H-Benzo[d]Imidazol-2-yl)(4-(4-(Trifluoromethyl)Benzyl)Piperazin-1-yl)Methanone Bis(4-Methylbenzenesulfonate)
- 中文名称(6-(1-((6-甲氧基吡啶-3-基)甲基)哌啶-4-基)-1H-苯甲酸[D]H-2-基)(4-(4-(三氟甲基)苄基)哌嗪-1-基)甲酮双(4-甲基苯磺酸酯)
- IUPAC名称(6-(1-((6-methoxypyridin-3-yl)methyl)piperidin-4-yl)-1H-benzo[d]imidazol-2-yl)(4-(4-(trifluoromethyl)benzyl)piperazin-1-yl)methanone bis(4-methylbenzenesulfonate)
- 其它别名(6-(1-((6-Methoxypyridin-3-yl)Methyl)Piperidin-4-yl)-1H-Benzo[d]Imidazol-2-yl)(4-(4-(Trifluoromethyl)Benzyl)Piperazin-1-yl)Methanone Bis(4-Methylbenzenesulfonate)
- CAS编号1640294-30-9
- MFCD编号:MFCD32693927
- FDA UNII编号:Q407FGG12F
- 分子式:C46H51F3N6O8S2分子量:937.08
- 产品CID: 833518
- 同类组份化合物CAS1640294-29-6 (free base)1640294-30-9 (tosylate)
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MSDS等安全信息
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主要参考文献
1: Xia YC, Zha JH, Sang YH, Yin H, Xu GQ, Zhen J, Zhang Y, Yu BT. AMPK activation by ASP4132 inhibits non-small cell lung cancer cell growth. Cell Death Dis. 2021 Apr 6;12(4):365. doi: 10.1038/s41419-021-03655-2.
2: Janku F, LoRusso P, Mansfield AS, Nanda R, Spira A, Wang T, Melhem-Bertrandt A, Sugg J, Ball HA. First-in-human evaluation of the novel mitochondrial complex I inhibitor ASP4132 for treatment of cancer. Invest New Drugs. 2021 Oct;39(5):1348-1356. doi: 10.1007/s10637-021-01112-7. Epub 2021 Apr 8. 28(5):115307. doi: 10.1016/j.bmc.2020.115307. Epub 2020 Jan 8. 68(5):452-465. doi: 10.1248/cpb.c20-00015.
合成参考文献
参考文献:10.1016/j.bmc.2020.115307
摘要:Kuramoto K, Yamada H, Shin T, Sawada Y, Azami H, Yamada T, Nagashima T, Ohnuki K. Development of a potent and orally active activator of adenosine monophosphate-activated protein kinase (AMPK), ASP4132, as a clinical candidate for the treatment of human cancer. Bioorg Med Chem. 2020 Mar 01;28(5):115307. doi: 10.1016/j.bmc.2020.115307.
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