CAS: 156042-32-9; N-Palmitoyl-L-Serine Tetradecyl Ester

上下游产品

N-Palmitoyl-L-Serine Methyl Ester

📜N-Palmitoyl-L-Serine Methyl Ester置于草酰氯,Palladium On Activated Charcoal,氢气,Sodium Hydride体系中,用 四氢呋喃,甲醇,二氯甲烷 用作溶剂,20.0 °C,3.0 Mpa 条件下,反应 15.5H,反应生成N-棕榈酰基-L-丝氨酸十四烷基酯
参考文献:一种pms的合成方法
标题:一种pms的合成方法
摘要:本发明公开了一种pms合成方法,属于有机合成技术领域.该方法是通过l‑丝氨酸甲酯盐酸盐和棕榈酰氯反应得到n‑棕榈酰基‑l‑丝氨酸甲酯;N‑棕榈酰基‑l‑丝氨酸甲酯通过苄基保护,甲酯水解得到n‑棕榈酰基‑o‑苄基‑l‑丝氨酸;N‑棕榈酰基‑o‑苄基‑l‑丝氨酸和十四醇酯化得到n‑棕榈酰基‑o‑苄基‑l‑丝氨酸十四烷基酯;最后n‑棕榈酰基‑o‑苄基‑l‑丝氨酸十四烷基酯脱苄基得到pms.本发明以廉价l‑丝氨酸甲酯盐酸盐为原料,通过苄基对羟基的保护,有效的规避了丝氨酸母体中羟基未保护时和十四醇酯化的副反应,提高反应转化率,同时降低了副产物带来的分离纯化的难度,能有效的适用于工业化大生产.

专利信息

专利号:US-11612556-B2
优先权日:2014-12-16
标 题:Peptidic compounds, compositions comprising them and uses of said compounds, in particular cosmetic uses
发明人：PESCHARD OLIVIER; DOUCET ANNE; LEROUX RICHARD; MONDON PHILIPPE
权利人:SEDERMA SA
摘要:The peptidic compound comprises at least an aminoacid which is lysine, ornithine, diaminopropionic acid or diaminobutyric acid or a derivative of these aminoacids, on which a carboxylic acid is grafted via a peptidic bound on the nitrogen of the lateral chain, said carboxylic acid comprising a (poly)cycle or (poly)heterocycle. Preferably, the grafted carboxylic acid is an aminoacid or a derivative, in particular selected from, a proline, a hydroxyproline or pyroglutamic acid.The peptidic compound can stimulate the synthesis of the main molecules constituting the extracellular matrix of the skin, especially collagen 1 and 4 and elastin. It can be used for topical cosmetic treatment such as a global anti-aging treatment, or for specific activities, including anti-wrinkles, moisturizing, to improve the mechanical properties of the skin, firmness/tone/elasticity/flexibility, to increase density and volume of the skin, improve skin radiance, for a restructuring effect and/or to fight stretch marks.

专利号:CA-2640585-A1
优先权日:2003-02-05
标题 :Synthesis of 2-butyl-3-(2'-(1-trityl-1h-tetrazol-5-yl)biphenyl-4-yl)-1,3-diazaspirol{4,4}-non-ene-4-one

专利号:CN-103320479-A
优先权日:2013-05-06
标 题 :A kind of method that immobilized lipase catalyzes the synthesis of L-serine stearyl ester