CAS: 119-98-2; Tocol

📜异植物醇,对苯二酚置于碳酸乙烯酯,对甲苯磺酸体系中,用 正庚烷 用作溶剂,化学反应 1.33H,以65%的收率获得2-甲基-2-(4,8,12-三甲基十三烷基)-6-色满醇
参考文献: Novel Use Of Substituted Chroman-6-Ols With Extended Lipophilic Side Chains[fr] Nouvelle Utilisation De Chroman-6-Ols Substitués à Chaînes Latérales Lipophiles étendues
标题: Novel Use Of Substituted Chroman-6-Ols With Extended Lipophilic Side Chains[fr] Nouvelle Utilisation De Chroman-6-Ols Substitués à Chaînes Latérales Lipophiles étendues
摘要:本发明涉及使用公式(i)的具有扩展亲脂侧链的取代的色甘醇-6-醇,其中两个取代基r1和r2中的一个是c12-21-烷基,另一个是氢或c1-5-烷基或(ch2)n-Oh,其中n是1到5的整数,且其中a为ch(r3),其中r3,R4和r6独立地为h或c1-4-烷基,其中r5为h或oh或c1-4-烷基或c1-4-烷氧基;但至少有r4,R5和r6中的两个不是甲基,当r3为h时,其中一个取代基r1和r2为甲基,另一个为c12-21-烷基,作为pufa含量的可食用油的抗氧化剂,例如海洋油,微生物油,真菌油,藻类油和含pufa的植物油,供人类食用.本发明进一步涉及包含这种具有扩展亲脂侧链的取代的色甘醇-6-醇的pufa含量的可食用油的方法(i).本发明还涉及一种保持可食用油中pufa和/或其酯的货架寿命的方法,其中包括将公式(i)的至少一种化合物添加到所述可食用油中,以及一种限制暴露于空气中的可食用油中pufa和/或其酯的氧化量的方法,包括向所述可食用油中添加至少一种公式(i)的化合物,优选地,该公式(i)的化合物的添加量为10至500 Ppm,优选地为30至300 Ppm,更优选地为100至250 Ppm,基于可食用油的总量.

专利信息

专利号:US-8293290-B2
优先权日:2003-04-08
标题:Annatto extract compositions, including geranyl geraniols and methods of use
发明人：TAN BARRIE
权利人:TAN BARRIE; AMERICAN RIVER NUTRITION INC
摘要:Annatto extract composition (AEC), including cis and trans geranyl geraniols (GG) and tocopherol-free C-5 unsubstituted tocotrienols (T3), increases the de novo synthesis of intermediate isoprenoid and distal protein products, including endogenous coenzyme Q10 (CoQ10), dolichols (DL) and all subsequent GG-prenylated and DL-glycosylated proteins, including GG-porphyrinated hemes. This intermediate and distal product replenishment by AEC reverses maladies of myotoxicity (of both drug and non-drug origins), including maladies that affect the muscle, kidney, eye, GI tract and skin, nerve, blood, and CoQ10-related syndromes of energetics and LDL protection. AEC anabolically increases the endogenous de novo CoQ10 synthesis via GG elongation/prenylation of side-chain and conversely CoQ10 catabolically increases the endogenous de novo GG synthesis via beta-oxidation of CoQ10. Also, such AEC decreases de novo synthesis and increases disposal of triglycerides (TG) in humans via PPAR activation and SREBP deactivation. Such drop in TG by AEC reverses maladies of insulin resistance (IR) and metabolic syndrome (MS), prediabetes, diabetes and diabetes-related cardiovascular diseases (CVD). GG activates PPAR and down regulates SREBP transcription factors. This AEC, containing GG, inhibits cancer growth whether or not GG involvement in protein prenylation is required.

专利号:US-11673874-B2
优先权日:2018-08-17
标 题 :Synthesis of chromanol derivatives
发明人：WEINGARTEN MELANIE; SIEGEL WOLFGANG; PUHL MICHAEL
权利人:BASF SE
摘要:The present invention relates to a process for the production of chromanol derivatives, more specifically to a process for preparing a compound of the general formula I wherein R 1 , R 2 and R 3 independently of each other are selected from hydrogen and methyl, R 4 is selected from C- 1 -C 6 -alkyl, and X is selected from C 1 -C 20 -alkyl and C 2 -C 20 -alkenyl.

专利号:US-12103918-B2
优先权日:2018-08-17
标题 :Synthesis of chromanol derivatives
发明人：WEINGARTEN MELANIE; SIEGEL WOLFGANG; PUHL MICHAEL
权利人:BASF SE
摘要:The present invention relates to a process for the production of chromanol derivatives, more specifically to a process for preparing a compound of the general formula (I) wherein R 1 , R 2 and R 3 independently of each other are selected from hydrogen and methyl, R 4 is selected from hydrogen and C 1 -C 6 -alkanoyl, and X is selected from C 1 -C 20 -alkyl and C 2 -C 20 -alkenyl.

专利号:US-12168649-B2
优先权日:2018-08-17
标 题 :Synthesis of chromanol and 2-methyl-1,4-naphthoquinone derivatives
发明人：WEINGARTEN MELANIE; SIEGEL WOLFGANG; PUHL MICHAEL
权利人:BASF SE
摘要:The present invention relates to a process for the production of chromanol and 2-methyl-1,4-naphthoquinone derivatives, more specifically to a process for preparing a compound of the general formula (I) or (II) wherein the variables are as defined in the claims and the description.

专利号:US-9309547-B2
优先权日:2012-05-22
标题:Methods for making tocoflexols and analogues thereof
发明人：ZHENG GUANGRONG; COMPADRE CESAR; HAUER-JENSEN MARTIN; CROOKS PETER; BREEN PHILIP
权利人:UNIV ARKANSAS; US DEPT VETERANS AFFAIRS; US OF AMERICA AS REPRESENTED BY THE DEPT OF VETERANS AFFAIRS
摘要:Methods for the synthesis of tocoflexols of Formula (I) and (II) and a number of related tocol analogs are provided herein. The methods are economical and amenable to large scale production and can be performed using either pure of partially purified tocotrienols as the starting material.

专利号:WO-2023248205-A1
优先权日:2022-06-23
标 题 :Novel ruthenium complexes, method of their synthesis, intermediate compounds used in this method, method of their synthesis and the use of novel ruthenium complexes in olefin metathesis reactions
发明人：GRELA KAROL; KAJETANOWICZ ANNA; SYTNICZUK ADRIAN; MILEWSKI MARIUSZ; PUROHIT VISHAL; STRUZIK FILIP
权利人:UNIV WARSZAWSKI
摘要:The subject of the invention is a novel ruthenium complex with the general formula Ru-1, in which all the variables have the meaning defined in the disclosure. The subject of the invention is also a synthesis method of the ruthenium complex, an intermediate which is a precursor of the ligand used in the synthesis reactions of the ruthenium complex CAAC-1 and application of this ruthenium complex as a (pre)catalyst in olefin metathesis reactions.