CAS: 10578-79-7; N4-Methylcytidine

相似化合物

65-46-3 147-94-4 26524-60-7

上下游产品

1-(2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl)-4-thiouracil methylamine methylamine hydr°Chloride Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-[2-oxo-4-(pyridin-3-yloxy)-2H-pyrimidin-1-yl]-tetrahydro-furan-3-yl esterCYTIDINE

📜尿嘧啶核苷置于吡啶,Tetraphosphorus Decasulfide体系中,化学反应生成N4-甲基胞苷
参考文献:Thiation Of Nucleosides. Ii. Synthesis Of 5-Methyl-2'-Deoxycytidine And Related Pyrimidine Nucleosides1
标题:Thiation Of Nucleosides. Ii. Synthesis Of 5-Methyl-2'-Deoxycytidine And Related Pyrimidine Nucleosides1
摘要:
Doi:10.1021/ja01510A042

专利信息

专利号:US-5726301-A
优先权日:1992-04-24
标题 :CAC H-phosphonate and its use in the synthesis of oligonucleotides
发明人：REDDY M PARAMESWARA; HANNA NAEEM B; FAROOQUI FIRDOUS
权利人:BECKMAN INSTRUMENTS INC
摘要:Disclosed herein are N4 protected deoxycytidines for use in the synthesis of oligonucleotides, the protecting groups being represented by the formula: -CO-(CH2)0-9-CH3. Preferred embodiments are N4 acetyl deoxycytidines and include N4 acetyl deoxycytidine phosphoramidites and N4 acetyl deoxycytidine H-phosphonates. When used to prepare oligonucleotides the protected deoxycytidine compounds provide high quality oligonucleotide products with little side product from cleavage and deprotection reactions carried out with alkyl amine compounds.

专利号:US-2023212204-A1
优先权日:2020-01-16
标题:Reagents and their use for modular enantiodivergent synthesis of c-p bonds
发明人：XU DONGMIN; RIVAS-BASCÓN NAZARET; KNOUSE KYLE W; PADIAL NATALIA; ZHENG BIN; VANTOUROUT JULIEN; SCHMIDT MICHAEL; EASTGATE MARTIN D; BARAN PHI
权利人:BRISTOL MYERS SQUIBB CO; SCRIPPS RESEARCH INST
摘要:The disclosure describes chiral P(V)-based reagents and their uses for the modular, scalable, and stereospecific synthesis of chiral phosphines, phosphine oxides and particular oligonucleotides.

专利号:US-2014378538-A1
优先权日:2011-12-14
标 题:Methods of responding to a biothreat
发明人：BANCEL STEPHANE
权利人:MODERMA THERAPEUTICS INC
摘要:The present disclosure provides for devices, in particular mobile devices, which may be used in the synthesis of modified nucleic acid molecules, in particular modified mRNA molecules. The device for making the modified nucleosides, modified nucleotides and modified nucleic acids (e.g., mRNA) disclosed herein may be mobile devices comprising at least one sample block for insertion of one or more sample vessels, a device base with electronic control units for the sample block, a voltage supply, and one or more reagent(s) for the synthesis of at least one nucleic acid.

专利号:US-5428148-A
优先权日:1992-04-24
标 题 :N4 - acylated cytidinyl compounds useful in oligonucleotide synthesis
发明人：REDDY PARAMESWARA M; HANNA NAEEM B
权利人:BECKMAN INSTRUMENTS INC
摘要:Disclosed herein are protecting groups for exocyclic amino groups of the bases adenine, guanine and cytosine for use in the synthesis of oligonucleotides, the protecting groups being represented by the formula: -CO- (CH2)0-9-CH3. In a particularly preferred embodiment, the base cytosine is protected with acetyl (-CO-CH3), and the oligonucleotide incorporating said protected cytosine is subjected to a cleavage/deprotection reagent comprising at least one straight chain alkylamine having from 1 to about 10 carbon atoms.

专利号:US-9790531-B2
优先权日:2012-08-14
标 题 :Enzymes and polymerases for the synthesis of RNA
发明人：WANG YUXUN; RAMAKRISHNAN DIVAKAR; DE FOUGEROLLES ANTONIN; WHORISKEY SUSAN
权利人:MODERNATX INC
摘要:The invention relates to compositions and methods for the design, evolution, preparation, and/or manufacture of enzymes for use with polynucleotides, primary transcripts and mmRNA molecules.

专利号:US-2025207163-A1
优先权日:2022-03-25
标 题:Methods and apparatus for synthesizing nucleic acids
发明人：HOPKINS PATRYCJA A; SHAHSAVARI SHAHIEN; BEGOYAN VAGARSHAK; NJUMA OLIVE J; DEBENHAM HOLLY S; EFCAVITCH J WILLIAM; ALBIZATI KIM F
权利人:MOLECULAR ASSEMBLIES INC
摘要:Methods for the synthesis of polynucleotides using polymerases nucleotide analogs with labile terminator groups that allow stepwise addition of nucleotides are described. These nucleotide analogs may have a modification on 3′, 2′, or 3′-2′-bridged hydroxyl groups or on nucleobase moieties and can be used in the synthesis of natural or modified polynucleotides suitable for use in biological systems. The labile terminator groups are removed under mild conditions or by enzymes. They are accepted as substrates by polymerases. The synthesis may be carried out on a surface.