CAS: 102507-13-1; (S)-2-((Tert-Butoxycarbonyl)Amino)-3-Hydroxy-3-Methylbutanoic Acid
该化合物是L-valine受保护的衍生物, 其特点是氮的三丁基碳基(Boc) 组和β位置的氢氧基碳基(Bc) 组. 该化合物广泛用于peptide合成, Boc组在这种合成中充当了矿山功能的临时保护组, 从而能够在温酸条件下有选择地去保护. 新增的氢氧组增强了其在建造复杂的peptide结构或改变侧链互动方面的效用. 它的高度纯度和稳定性使它适合药物研究和精细化学应用. 化合物的立体化学学确保与手相合成的兼容性, 支持生物活分子的开发.
- 英文名称(S)-2-((Tert-Butoxycarbonyl)Amino)-3-Hydroxy-3-Methylbutanoic Acid
- 中文名称(S)-2-((叔丁氧基羰基)氨基)-3-羟基-3-甲基丁酸
- IUPAC名称(S)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-3-methylbutanoic acid
- 其它别名(S)-2-((叔丁氧羰基)氨基)-3-羟基-3-甲基丁酸; N-Boc-(S)-2-Amino-3-Hydroxy-3-Methylbutanoic Acid
- CAS编号102507-13-1
- MFCD编号:MFCD03094792
- EINECS号:676-409-9
- 分子式:C10H19NO5分子量:233.26
- 产品CID: 55834
- 产品分类有机原料→分子砌块→手性化合物→手性砌块
相似化合物
288159-40-0 1217603-41-2 2280-48-0物理性质
MSDS等安全信息
- GHS象形图
- GHS符号GHS07;
注释: Exclamation mark - 危险类别特定目标器官毒性 - 单次接触 类别3
皮肤腐蚀/刺激 类别2
严重眼刺激 类别2
急性毒性 类别4(经口)
严重眼刺激 类别2A - 警示词Warning(警告)
- 危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H302 |吞咽有害. - 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
- 危险等级IRRITANT
- 危险品标志Xi
- 安全声明26-36/37/39
- 危险类别码36/37/38
欧盟法规
C&L通报上下游产品
CAS号473545-40-3 叔丁基[(1R)-2-羟基-1... | CAS号288159-36-4 tert-butyl (4R)... | CAS号75-16-1 甲基溴化镁 | CAS号95715-85-8 B°C-D-丝氨酸甲酯 | CAS号2280-27-5 (S)-(+)-2-氨基-3-... | CAS号34619-03-9 碳酸二叔丁酯 | CAS号108149-60-6 (S)-(-)-3-B°C-4... | CAS号2280-28-6 (R)-2-氨基-3-羟基-3-甲基丁酸 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号2280-27-5 (S)-(+)-2-氨基-3-... | CAS号102507-19-7 (S)-2-(n-b°C-氨基...合成工艺路线路线简述
- 合成目标产物 N-Boc-(S)-2-Amino-3-Hydroxy-3-Methylbutanoic Acid 主要起始原料 Carbamic Acid, [2-Hydroxy-1-(Hydroxymethyl)-2-Methylpropyl]-, 1,1-
- (文献来源)合成步骤主要原料 Carbamic Acid, [2-Hydroxy-1-(Hydroxymethyl)-2-Methylpropyl]-, 1,1-
📜(S)-(-)-3-Boc-4-甲氧羰基-2,2-二甲基-1,3-恶唑烷置于sodium Chlorite,2,2,6,6-四甲基哌啶氧化物,碘苯二乙酸,对甲苯磺酸体系中,用 四氢呋喃,甲醇,乙醚,乙腈 用作溶剂,化学反应 20.5H,反应生成N-Boc-3-羟基-L-缬氨酸
参考文献:Gold-Catalyzed Amide/carbamate-Linked N,O-Acetal Formation With Bulky Amides And Alcohols
标题:Gold-Catalyzed Amide/carbamate-Linked N,O-Acetal Formation With Bulky Amides And Alcohols
摘要:A Gold-Catalyzed N,O-Acetal Formation Was Established To Construct An Amide/carbamate-Linked N,O-Acetal Substructure With Bulky Alcohols. The Acyliminium Cation Species Generated From O-Alkynylbenzoic Acid Ester In The Presence Of A Gold Catalyst Is Highly Reactive And Underwent Nucleophilic Attack Of Various Bulky Alcohols And Phenols At Room Temperature Under Neutral Conditions,Leading To The Corresponding N,O-Acetals In Yields Of 34-89% With Good Functional Group Tolerance.
Doi:10.1021/acs.Joc.0C02640
海关参考信息
- 2905122000-异丙醇
2905143000-叔丁醇
2905399001-1,3-丙二醇
2905142000-仲丁醇
2905499000-其他多元醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-11230553-B2
优先权日:2016-05-09
标 题:Nannocystin process and products
发明人：WANG ZHANG; HUANG JUN
权利人:UNIV NEW YORK STATE RES FOUND
摘要:Described herein is a process for the total synthesis of macrolactones and macrolactams of formula Iincluding E- and Z-configuration thereof, in particular, nannocystins.
专利号:US-2014275007-A1
优先权日:2013-03-14
标题:Oxamazin antibiotics
发明人：GLINKA TOMASZ; HECKER SCOTT; RODNY OLGA
权利人:REMPEX PHARMACEUTICALS INC
摘要:Disclosed herein are oxamazin monobactam compounds and their use as antibiotics resistant to degradation by β-lactamases. Also disclosed are pharmaceutical compositions containing the compounds and methods of synthesis.
专利号:WO-2014164526-A1
优先权日:2013-03-13
标 题:Oxamazin antibiotics
发明人：GLINKA TOMASZ; HECKER SCOTT; RODNY OLGA
权利人:REMPEX PHARMACEUTICALS INC
摘要:Disclosed herein are oxamazin monobactam compounds and their use as antibiotics resistant to degradation by β-lactamases. Also disclosed are pharmaceutical compositions containing the compounds and methods of synthesis.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考文献:10.1055/s-0037-1611796
摘要:Wang Z. The Chemical Syntheses of Nannocystins. Synthesis. 2019 Apr 17;51(11):2252–60. doi: 10.1055/s-0037-1611796.
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