CAS: 819812-04-9; 2-(2-Ethyl-3,5-Dihydroxy-6-(3-Methoxy-4-(2-Morpholinoethoxy)Benzoyl)Phenyl)-N,N-Bis(2-Methoxyethyl)Acetamide

专利信息

专利号:WO-2014018862-A1
优先权日:2012-07-27
标 题 :Pharmaceutical compositions comprising a heat shock protein inhibitor and a; purine de novo synthesis inhibitor for treating rheumatoid arthritis or cancer
发明人：FANG YE
权利人:CORNING INC; FANG YE
摘要:A pharmaceutical composition including an effective amount of the combination of: an heat shock protein (HSP) inhibitor, and a purine de novo biosynthesis inhibitor, or a pharmaceutically acceptable salt thereof. Also disclosed is a method of treating rheumatoid arthritis or cancer including administering an effective amount of the above mentioned pharmaceutical composition to a patient in need of such treatment, as defined herein.

专利号:WO-2013002253-A1
优先权日:2011-06-27
标 题 :Method for producing benzophenone derivative
发明人：MATSUMURA TSUTOMU; SAITOH TOSHIKAZU; TAKEMURA KAZUNOBU; KOBAYASHI KENTARO; NITTA MARIKO; HAGIHARA KOJI
权利人:KYOWA HAKKO KIRIN CO LTD; MATSUMURA TSUTOMU; SAITOH TOSHIKAZU; TAKEMURA KAZUNOBU; KOBAYASHI KENTARO; NITTA MARIKO; HAGIHARA KOJI
摘要:Provided are: a compound represented by general formula (I) (wherein R 1a and R 1b may be the same as or different from each other and independently represent a benzyl group substituted by one to three halogen atoms, wherein, when the number of the halogen atoms is two or three, the halogen atoms may be the same as or different from each other; R 2 represents a lower alkyl group which may have a substituent; and R 3 represents a lower alkoxycarbonyl group which may have a substituent) or a salt thereof, which is useful in, for example, a method for producing an intermediate for the synthesis of a benzophenone derivative having an anti-tumor activity and the like; a method for producing a benzophenone derivative represented by general formula (III) (wherein R 1a , R 1b , R 2 and R 3 are as defined above; R 4 represents a lower alkyl group which may have a substituent; and R 5 represents an aliphatic heterocyclic alkyl group which may have a substituent) or a salt thereof, the method being characterized by comprising reacting a compound represented by general formula (II) (wherein R 4 and R 5 are as defined above) or a salt thereof in the presence of an acid; and others.

专利号:US-11312722-B2
优先权日:2019-05-08
标 题:Hsp90 inhibitors and uses thereof
发明人：BROWN LAUREN ELAINE; HUANG DAVID S; COWEN LEAH E; WHITESELL LUKE; MARCYK PAUL
权利人:UNIV BOSTON; GOVERNING COUNCIL UNIV TORONTO
摘要:Herein is described the design and synthesis of resorcylate aminopyrazole compounds. These compounds show broad, potent and fungal-selective Hsp90 inhibitory activity. These compounds also find use in treating Hsp90 related diseases.