CAS: 77472-70-9; 2-(2-Oxo-4-Phenylpyrrolidin-1-yl)Acetamide

上下游产品

CAS号70291-40-6 2-Oxo-4-phenyl-... | CAS号68497-63-2 methyl-2-oxo-4-... | CAS号1198-97-6 4-苯基-2-吡咯烷酮 | CAS号3060-41-1 3-苯基-4-氨基丁酸盐酸盐 | CAS号77519-55-2 2-氧代-4-苯吡咯烷-3-羧酸 | CAS号55790-17-5 2-氧代-4-苯基-3-吡咯烷羧酸甲酯

📜3-苯基-4-氨基丁酸盐酸盐置于三氟甲磺酸三甲基硅酯 Ammonium Hydroxide体系中,化学反应 5.5H,反应生成 4-苯基-2-吡咯烷酮-1-乙酰胺
参考文献:Kramarova,E. P.; Shipov,A. G.; Orlova,N. A.,Journal Of General Chemistry Of The Ussr,1988,Vol. 58,# 5,P. 970-979
标题:Kramarova,E. P.; Shipov,A. G.; Orlova,N. A.,Journal Of General Chemistry Of The Ussr,1988,Vol. 58,# 5,P. 970-979

专利信息

专利号:US-8791273-B2
优先权日:2009-11-05
标 题 :4R,5S-enantiomer of 2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide with nootropic activity
发明人：KALVINS IVARS; LEBEDEVS ANTONS; CERNOBROVIJS ALEKSANDRS; DAMBROVA MAIJA; ZVEJNIECE LIGA; VORONA MAKSIMS; VEINBERGS GRIGORIJS
权利人:KALVINS IVARS; LEBEDEVS ANTONS; CERNOBROVIJS ALEKSANDRS; DAMBROVA MAIJA; ZVEJNIECE LIGA; VORONA MAKSIMS; VEINBERGS GRIGORIJS; JSC GRINDEKS
摘要:The invention relates to the 5S,4R-enantiomer of 2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide with cognition enhancing activity of high pharmacological value and to its preparation method which includes the synthesis of 5S-methyl-4R-phenylpyrrolidin-2-one, its N-alkylation with ethyl haloacetate and the treatment of intermediate ethyl 2-(5S-methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetate with ammonia.

专利号:US-2009176740-A1
优先权日:2007-11-30
标题:Treatment of neurological conditions by the co-administration of aniracetam and l-alpha glycerylphosphorylcholine
发明人：PHILLIPS II DAUGLAS JAMES
权利人:PHILLIPS II DAUGLAS JAMES
摘要:Aniracetam (1-[(4-methoxybenzoyl)]-2-pyrrolidinone) is co-administered with the acetylcholine precursor 1-alpha glycerylphosphorylcholine (Alpha GPC, choline alfoscerate, choline alphoscerate) to potentiate cognition enhancing effects in healthy subjects and patients suffering from neurological conditions including Alzheimer's Disease (AD), attention deficit disorder (ADD), Parkinson's Disease, schizophrenia, vascular dementia, post stroke aphasia, anxiety disorders, cerebral atrophy, chronic alcoholism, Down syndrome, dyslexia, and various other neurodegenerative conditions. The co-administration of aniracetam (and other racetam derivatives including oxiracetam) with the acetylcholine precursor 1-alpha glycerylphosphorylcholine decreases negative side-effects such as severe headaches while increasing the synthesis and release of the neurotransmitters acetylcholine and glutamate to facilitate proper brain functioning.

专利号:RU-2488576-C2
优先权日:2011-11-08
标 题:Method for enantioselective synthesis of (r)-diethyl(2-nitro-1-phenylethyl) malonate in presence of nickel complex

专利号:US-2016250185-A1
优先权日:2013-10-22
标 题 :Pharmaceutical composition for controlling body mass gain comprising s-phenotropil
发明人：KALVINS IVARS; ZVEJNIECE LIGA; VARACEVA LARISA; CERNOBROVIJS ALEKSANDRS; LEBEDEVS ANTONS; DAMBROVA MAIJA; SVALBE BAIBA; LIEPINS EDGARS
权利人:LATVIAN INST ORGANIC SYNTHESIS
摘要:The invention relates to medicine, in particular S-Phenotropil ((S)-2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide) containing pharmaceutical compositions and their use in control of body mass gain.