CAS: 77-91-8; 2-Hydroxy-N,N,N-Trimethylethan-1-Aminium 3,4-Dicarboxy-3-Hydroxybutanoate

相似化合物

67-48-1 1927-06-6 17773-10-3

专利信息

专利号:US-11897860-B2
优先权日:2022-03-14
标题 :Direct synthesis of cyclic carbonates using choline chloride as catalyst under mild conditions
发明人：CARRASCO ANALETTE; WEERS JERRY J; BLACKWELL CATHERINE C; MURUGESAN SANKARAN; WANG XIAOFENG; NUGENT DOUGLAS; ROBERTS CORBY A
权利人:BAKER HUGHES OILFIELD OPERATIONS LLC
摘要:A method for direct synthesis of cyclic carbonates is achieved by reacting at least one epoxide with carbon dioxide in the presence of a choline catalyst, such as choline chloride, under mild conditions such as a temperature between about 25° C. to 150° C. and a pressure of from about atmospheric to 75 psi (0.52 MPa), in a cyclic carbonate solvent. The choline catalyst may be the only catalyst used, and a co-catalyst or hydrogen bond donor is not necessary. The concentration of choline catalyst in the solvent ranges from about 0.5 mol % to about 10 mol %, based on the epoxide.

专利号:WO-2024231663-A1
优先权日:2023-05-05
标题:Method of synthesis
发明人：ANDREEVA LARISA
权利人:MITOCHOLINE LTD
摘要:The present invention provides methods of synthesis of di-choline succinate (DISU) and DISU formulations that are slightly hygroscopic or non-hygroscopic. The DISU formulations of the invention are suitable as food products or dietary supplements.

专利号:US-10736912-B2
优先权日:2005-05-23
标 题 :Compositions containing PUFA and/or uridine and methods of use thereof
发明人：WURTMAN RICHARD; RICHARDSON INGRID
权利人:MASSACHUSETTS INSTITUE OF TECH; MASSACHUSETTS INST TECHNOLOGY
摘要:This invention provides methods of enhancing brain development; increasing or enhancing intelligence; increasing or enhancing synthesis and levels of phospholipids, synapses, synaptic proteins, and synaptic membranes by a neural cell or brain cell, comprising contacting a subject or a pregnant or nursing mother thereof with a composition comprising an omega-3 fatty acid, an omega-6 fatty acid, and/or uridine, a metabolic precursor thereof, or a combination thereof.

专利号:US-2009176740-A1
优先权日:2007-11-30
标题:Treatment of neurological conditions by the co-administration of aniracetam and l-alpha glycerylphosphorylcholine
发明人：PHILLIPS II DAUGLAS JAMES
权利人:PHILLIPS II DAUGLAS JAMES
摘要:Aniracetam (1-[(4-methoxybenzoyl)]-2-pyrrolidinone) is co-administered with the acetylcholine precursor 1-alpha glycerylphosphorylcholine (Alpha GPC, choline alfoscerate, choline alphoscerate) to potentiate cognition enhancing effects in healthy subjects and patients suffering from neurological conditions including Alzheimer's Disease (AD), attention deficit disorder (ADD), Parkinson's Disease, schizophrenia, vascular dementia, post stroke aphasia, anxiety disorders, cerebral atrophy, chronic alcoholism, Down syndrome, dyslexia, and various other neurodegenerative conditions. The co-administration of aniracetam (and other racetam derivatives including oxiracetam) with the acetylcholine precursor 1-alpha glycerylphosphorylcholine decreases negative side-effects such as severe headaches while increasing the synthesis and release of the neurotransmitters acetylcholine and glutamate to facilitate proper brain functioning.

专利号:WO-2025120626-A2
优先权日:2025-04-14
标题 :Synthetic method
发明人：ANDREEVA LARISA
权利人:MITOCHOLINE LTD
摘要:The present invention relates to a two-step method of synthesis of di-choline succinate (DISU) from trimethylamine, succinic acid and ethylene oxide suitable for a large-scale production of the compound.

专利号:US-10391166-B2
优先权日:2013-02-18
标 题:Short oligonucleotides as vaccine adjuvants and therapeutic agents
发明人：IYER RADHAKRISHNAN P
权利人:SPRING BANK PHARMACEUTICALS INC; SPRING BREAK PHARMACEUTICALS INC
摘要:The invention provides a method of treating a microbial infection in a subject and a method of improving an immune system response in a subject against a disease, condition, infection, or virus thereof, by administering an effective amount of a nucleoside, short oligonucleotide compound or an analog thereof, or a pharmaceutically acceptable salt, racemate, enantiomer, diastereomer, geometric isomer, or tautomer thereof. In addition, the invention provides methods for treating or preventing a viral infection, bacterial infection, parasitic infection, or fungal infection in a subject (such as, a human). The compounds of the invention include, for example, di-, and trinucleotide compounds as provided herein. The compounds of the invention are useful for different therapeutic applications including, such as, prophylactics and therapeutics. The invention also provides design and synthesis of a compound that is useful for various therapeutic applications as mentioned herein.