CAS: 7057-33-2; 4-Amino-1-((2R,3R,5S)-3-Hydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-yl)Pyrimidin-2(1H)-One

相似化合物

147-94-4 26524-60-7 13913-16-1

上下游产品

5'-O-trityl-3'-deoxycytidine 4,O2',O5'-tripivaloyl-3'-O-mesylcytidineN4,O2',O5'-tripivaloyl-3'-O-mesylcytidine 4-acetyl-2',5'-di-O-p-chlorobenzoyl-3'-deoxycytidineN4-acetyl-2',5'-di-O-p-chlorobenzoyl-3'-deoxycytidine 2',5'-di-O-acetyl-3'-deoxycytidine 4-benzoyl-3'-deoxyribicytidineN4-benzoyl-3'-deoxyribicytidine 4-2-(4-nitrophenyl)ethoxycarbonyl-3'-deoxycytidiN4-2-(4-nitrophenyl)ethoxycarbonyl-3'-deoxycytidi 4-(4,4'-dimethoxytrityl)-3'-deoxycytidineN4-(4,4'-dimethoxytrityl)-3'-deoxycytidine (2R,3R,5S)-2-(6-amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)oxolan-3-ol

胞苷置于phosphinic Acid,Copper(II) Sulfate,三乙胺,Sodium Hydroxide体系中,用 甲醇,水,二甲基亚砜,乙腈 作为反应溶剂,化学反应 23.33H,反应生成 3-脱氧胞苷
参考文献:一种3'-脱氧尿苷的制备方法
标题:一种3'-脱氧尿苷的制备方法
摘要:本发明涉及药物合成领域,具体是一种3'‑脱氧尿苷的制备方法,以化合物3为原料,先经乙酸酐保护氨基得到化合物4,再在乙酰溴作用下得到化合物5,经过次磷酸盐体系还原得到化合物6;在高压水蒸气与有机溶剂的作用下脱去脱乙酰氨基得化合物8或n‑乙酰基得化合物7,最后脱去全部乙酰基得到3'‑脱氧尿苷和3'‑脱氧胞苷的混合物,分离纯化分别得到3'‑脱氧尿苷和3'‑脱氧胞苷晶体;也可以由化合物6直接脱去全部乙酰基得到3'‑脱氧胞苷.本发明采用易得的天然产物为起始原料,操作简单,纯化方便,极易工业化大规模生产.

专利信息

专利号:US-11858953-B2
优先权日:2018-04-04
标 题:Compositions and methods for synthesis of phosphorylated molecules
发明人：CHAPUT JOHN; LIAO JEN-YU; BALA SAIKAT
权利人:UNIV CALIFORNIA
摘要:The invention provides compositions and methods for synthesis of phosphorylated organic compounds, including nucleoside triphosphates.

专利号:US-2020239500-A1
优先权日:2018-04-04
标 题 :Compositions and Methods for Synthesis of Phosphorylated Molecules

专利号:US-9738678-B2
优先权日:2007-07-09
标 题 :Substituted nucleoside derivatives with antiviral and antimicrobial properties
发明人：DONCEL GUSTAVO F; PARANG KEYKAVOUS; AGARWAL HITESH KUMAR
权利人:EASTERN VIRGINIA MEDICAL SCHOOL; BOARD OF GOVERNORS FOR HIGHER EDUCATION STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS
摘要:The present invention relates to fatty acid and fatty alcohol substituted nucleoside derivatives and nucleoside and nucleoside derivatives substituted on multivalent scaffolds (e.g., polymers, peptides, polycarboxylic acid substituted compounds, compounds containing polycycloSaligenyl groups) that display potent anti-HIV activity. Furthermore, they show enhanced activity against multi-drug resistant, R5, and cell-associated virus. Some of them also display activity against other sexually transmitted pathogens and sperm. The present invention provides their methods of synthesis, composition of matter, and methods of use. Emphasis is placed on their application as topical microbicides to treat or prevent sexual transmission of disease, especially HIV/AIDS.

专利号:WO-2019195494-A1
优先权日:2018-04-04
标 题:Compositions and methods for synthesis of phosphorylated molecules

专利号:US-2011245484-A1
优先权日:2010-03-31
标 题 :Stereoselective synthesis of phosphorus containing actives

专利号:WO-2011123668-A2
优先权日:2010-03-31
标 题:Stereoselective synthesis of phosphorus containing actives