CAS: 629-04-9; 1-Bromoheptane

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正庚醇置于1-丁基-4-甲基吡啶溴盐,对甲苯磺酸体系中,化学反应 5.0H,反应生成 1-溴代庚烷
参考文献:使用基于吡啶的离子液体将醇有效转化为烷基溴:Appel 反应的绿色替代方案
标题:使用基于吡啶的离子液体将醇有效转化为烷基溴:Appel 反应的绿色替代方案
摘要:烷基卤化物广泛用作工业溶剂,也用作制备各种精细化学品的必要前体.将醇转化为烷基卤的经典程序称为 Appel 反应,在经典示例中需要在苛刻的反应条件下使用 Nabr 和 H2So4 [1].作为环境不可接受的过程,这种合成在今天具有有限的合成适用性.由于羟基的离去基团特性差,将醇直接转化为卤代烷是很困难的,但是已经报道了几种改进的方法来克服这个缺点.报道了一种优雅的转化程序,其中使用了三苯基膦和四卤代烷烃 [2].其他值得注意的合成程序是 Mitsunobo 反应 [3],2,4 的反应,6-三氯-[1,3,5]-三嗪 (Tct)置于dmf 中,然后加入反应物醇的 Ch2Cl2 溶液 [4],醇与 2,3-三氯-5,6-二氰基苯醌的反应在三苯基膦,Ch2Cl2 和相转移催化剂存在下 [5].romp-Gel 支持三苯基膦 [6],磷 (V) 介导的亲核取代反应 [7] 以及最后使用氟膦 [
DOI:10.14233/ajchem.2018.21086

专利信息

专利号:US-8084007-B2
优先权日:2004-01-30
标题 :Methods of synthesis of isotropically enriched borohydride and methods of synthesis of isotropically enriched boranes
发明人：SPIELVOGEL BERNARD; COOK KEVIN S
权利人:SPIELVOGEL BERNARD; COOK KEVIN S; SEMEQUIP INC
摘要:The invention provides new methods for the synthesis of isotopically enriched metal borohydrides, metal tetrahydroundecaborate salts, and decaborane from isotopically enriched 10 B-boric acid or 11 B-boric acid. The invention is particularly useful for synthesis of isotopically enriched sodium or lithium borohydride, MB 11 H 14 (where M is Li, Na, K, or alkylammonium), and decaborane.

专利号:US-7767826-B2
优先权日:2007-10-05
标题 :Process for the synthesis of L-(+)-ergothioneine
发明人：TRAMPOTA MIROSLAV
权利人:PHARMATECH INTERNATIONAL INC
摘要:This invention relates to a novel process for the preparation of optically pure L-(+)-ergothioneine. The process for the chemical synthesis of L-ergothioneine comprises steps which consist of reacting L-histidine alkyl ester with an acid halide, chloroformate or pyrocarbonate in the presence of a base, hydrolysis of the alkyl-(S,Z)-2,4,5-triamidopent-4-enoate to obtain a (S)-alkyl 2,5-diamido-4-oxopentanoate, acid catalyzed hydrolysis of the (S)-alkyl 2,5-diamido-4-oxopentanoate followed by reaction with a metal thiocyanate to obtain the thiohistidine, protection of the sulfur of thiohistidine as the tert-butyl thioether, dialkylation of the primary amine to obtain a tertiary amine, quaternization of the tertiary amine, and removal of the protecting group to obtain the desired (S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trialkylammonio)propanoate (I). This process affords a better yield and is capable of practical application at large scale.

专利号:US-9765027-B2
优先权日:2014-08-22
标题 :Substituted 1-arylethyl-4-acylaminopiperidine derivatives as opioid/alpha-adrenoreceptor modulators and method of their preparation
发明人：VARDANYAN RUBEN S; HRUBY VICTOR J
权利人:THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIV OF ARIZAONA; UNIV ARIZONA
摘要:The invention provides compounds that bind with high affinities to the μ-, δ- and κ-opioid receptors and α 2 -adrenoreceptor. In addition to providing these compounds with novel pharmacological binding properties, the invention also describes detailed novel methods for the preparation of representative compounds and a scheme for the synthesis of related compounds that bind to the opioid receptors and/or α 2 -adrenoreceptor.

专利号:US-6222073-B1
优先权日:1998-01-17
标题:Catalytic synthesis of N-alkylated anilines from olefins and anilines
发明人：HERWIG JUERGEN; BELLER MATTHIAS; BREINDL CLAUDIA; TRAUTHWEIN HARALD; EICHBERGER ELISABETH; EICHBERGER ANTON
权利人:AVENTIS RES & TECH GMBH & CO
摘要:Process for the preparation of an N-arylethylaniline of the formula (I)by reacting an aromatic olefin of the formula (II)with an aniline of the formula (III)in an inert solvent in the presence of at least one basic catalyst selected from the group consisting of alkali metal alcoholates and alkaline earth metal alcoholates or alkali metal amides and alkaline earth metal amides, where, in the formulae (I) to (III),Ar and Ar', independently of one another, are an aryl radical selected from the group consisting of the fused and nonfused C6-C22-aromatics and of the fused or nonfused C5-C22heteroaromatics which have at least one nitrogen, oxygen or sulfur atom in the ring;R1, R2 and R3, independently of one another, are a hydrogen atom, a C1-C8-alkyl radical or an aryl radical Ar; andn is the number 1 or 2.

专利号:US-8975427-B2
优先权日:2010-04-28
标题 :Synthesis of alkyl cyclopentadiene compounds
发明人：HARLAN C JEFF; CAO XIANYI; RIX FRANCIS C
权利人:HARLAN C JEFF; CAO XIANYI; RIX FRANCIS C; UNIVATION TECH LLC
摘要:A method of synthesizing an alkyl cyclopentadiene compound is disclosed. The method includes contacting at least one cyclopentadienyl anion source and at least one alkyl group source to form at least one alkyl cyclopentadiene compound. The method further includes extracting the alkyl cyclopentadiene compound with a hydrocarbon solvent. The alkyl cyclopentadiene compound may be converted to a metallocene catalyst compound.

专利号:US-3954585-A
优先权日:1974-02-21
标题 :Synthesis of trifluoromethyl-substituted compounds
发明人：LAGOW RICHARD J; GERCHMAN LOIS L; JACOB ROBERT A
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Trifluoromethyl-substituted compounds are formed in a corona discharge or glow discharge plasma of trifluoromethyl radicals from an organic trifluoromethyl source. A substrate possessing easily replaceable ligands such as halogen or carbonyl, is initially contacted either in the plasma and within a short distance from a downstream visible edge of the plasma or outside of the visible portion of the plasma and within a short distance from the downstream visible edge, to effect a substitution of the halogen or carbonyl ligand on the substrate with a trifluoromethyl radical without substantial decomposition of the substrate.