CAS: 61477-40-5; (R)-3-Aminobutan-1-Ol

相似化合物

2867-59-6 61477-39-2 146514-31-0

上下游产品

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4-羟基-2-丁酮置于d-丙氨酸,磷酸吡哆醛,Recombinant (R)-Selective Transaminase H30R/y90F/v152K/y156F Mutant From Fodinicurvata Sediminis体系中,用 Aq. Phosphate Buffer,二甲基亚砜 作为反应溶剂,以99.9%的收率获得产物
参考文献:工程化 (R)-选择性转氨酶用于不对称合成 (R)-3-氨基丁醇
标题:工程化 (R)-选择性转氨酶用于不对称合成 (R)-3-氨基丁醇
摘要:()-选择性转氨酶有望作为手性胺不对称合成的催化剂,手性胺是各种小分子药物的组成部分.然而,它们的应用受到底物接受性差和催化效率低的限制.在这里,通过底物截短策略鉴定了来自 (Fsta) 的潜在 ()-选择性转氨酶,并将其用作催化 4-羟基-2-丁酮(一种对催化提出挑战的底物)的酶工程的起点.分子对接和动力学模拟表明,Y90 是导致底物结合不良的关键残基.从具有初始活性的变体(y90F,Mut1)开始,通过活性位点重塑和共有序列策略对 Fsta 进行系统性修饰以改善底物结合,产生具有改进活性的三个变体(h30R,V152K 和 Y156F).还发现四重突变变体 H30R/y90F/v152K/y156F (Mut4) 的催化效率 (/) 比初始变体 Mut1 高 7.95 倍.此外,Mut4还显着增强了酶的热稳定性,增加了10oc.该变体还表现出对野生型不接受或接受程度较差的一系列酮的显着改
DOI:10.1016/j.Bioorg.2024.107264

专利信息

专利号:US-11912647-B2
优先权日:2020-05-22
标 题:Diversity-oriented synthesis of N,N,O-trisubstituted hydroxylamines from alcohols and amines by N—O bond formation
发明人：CRICH DAVID; HETTIKANKANAMALAGE ASIRI; HILL JARVIS
权利人:UNIV GEORGIA
摘要:In one aspect, the disclosure relates to a method for the direct synthesis of complex N,N,O-trisubstituted hydroxylamines by N—O bond formation. In another aspect, the method can successfully be employed using a wide variety of commercially available alcohols and secondary amines and enables the construction of large fragment-based libraries of trisubstituted hydroxylamines for drug discovery purposes. Also disclosed are N,N,O-trisubstituted hydroxylamines having low basicity, high stability at ambient temperatures, and an inherent lack of reactivity towards acetylating and sulfonylating enzymes that confer mutagenicity on less-substituted hydroxylamines.

专利号:US-2025034607-A1
优先权日:2021-12-03
标题 :Process of Synthesizing (R)-3-aminobutan-1-ol
发明人：BOBKO MARK; FUERST DOUGLAS; MORGAN CHRISTOPHER
权利人:VIIV HEALTHCARE CO
摘要:The present invention relates to an aminotransaminase useful in the synthesis of (R)-3-aminobutan-1-ol (RABO). The present invention also provides a process of preparing (R)-3-aminobutan-1-ol (RABO) with the disclosed aminotransaminase.

专利号:US-9365587-B2
优先权日:2008-12-11
标 题:Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates
发明人：YOSHIDA HIROSHI; TAODA YOSHIYUKI; JOHNS BRIAN ALVIN; KAWASUJI TAKASHI; NAGAMATSU DAIKI
权利人:SHIONOGI & CO; VIIV HEALTHCARE CO
摘要:The invention is a process for the preparation of a compound of the following formula (I): n nwherein R is —CHO, —CH(OH) 2 or —CH(OH)(OR 4 ); P 1 is H or a hydroxyl protecting group; P 3 is H or a carboxy protecting group; R 3 is H, halogen, hydroxy, optionally substituted lower alkyl, optionally substituted cycloalkyl, etc.; R x is H, halogen or R 2 —X—NR 1 —C(O)—; etc. as defined in the specification. The compounds are useful as intermediates in synthesizing compounds having HIV integrase inhibitory activity.

专利号:WO-2015019310-A1
优先权日:2013-08-07
标 题 :Process for the preparation of dolute-gravir and intermediates thereof
发明人：DANDALA RAMESH; VELLANKI SIVA RAM PRASAD; NADELLA MADHU MURTHY; BALUSU PHANI KUMAR
权利人:MYLAN LAB LTD
摘要:The present disclosure relates to processes for the preparation of dolutegravir or of its pharmaceutically acceptable salts. The present disclosure also provides intermediates useful in the synthesis of dolutegravir.

专利号:US-11248005-B2
优先权日:2019-07-08
标 题 :Process for preparation of intermediates used for the synthesis of HIV integrase inhibitor
发明人：JADHAV HARISHCHANDRA SAMBHAJI; SHRIVASTAVA DHANANJAI; AHER UMESH PARASHARAM; DEOKAR SHARAD CHANDRABHAN; NALE DEEPAK BABASAHEB; HONRAO SURYAKANT TUKARAM; SINGH GIRIJ PAL
权利人:LUPIN LTD
摘要:Provided herein is a process for the intermediates used for preparation of HIV Integrase Inhibitor such as Bictegravir, Dolutegravir, Cabotegravir or their pharmaceutically acceptable salts.

专利号:US-8754214-B2
优先权日:2008-12-11
标题 :Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates