CAS: 556-03-6; Dl-Tyrosine

相似化合物

60-18-4 1164-16-5 3978-80-1

上下游产品

2-acetylamino-2-(4-methoxybenzyl)malonic acid diethyl ester 2-benzoylamino-3-(4-hydroxy-phenyl)-acrylic acid (p-aminophenyl)alanine [2-hydroxyimino-3-(4-hydroxyphenyl)]propionic acidmethyl 2-amino-3-(4-methoxyphenyl) propanoate N-formyl-DL-tyrosineN-formyl-DL-tyrosine 7-hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid tyrosine isopentyl ester

L-苯丙氨酸置于盐酸体系中,化学反应生成 Dl-酪氨酸
参考文献:Nitrosylation Of Protein Sh Groups And Amino Acid Residues As A
标题:Nitrosylation Of Protein Sh Groups And Amino Acid Residues As A
摘要:蛋白质和氨基酸基团的亚硝基化使得蛋白质功能可以进行选择性调节,并赋予蛋白质和氨基酸额外的平滑肌松弛和血小板抑制能力.因此,本发明涉及通过蛋白质巯基的亚硝基化而实现的新化合物.这些化合物包括:S-亚硝基-T-Pa,S-亚硝基-半胱氨酸蛋白酶;s-亚硝基-脂蛋白;以及s-亚硝基-免疫球蛋白.该发明还涉及利用s-亚硝基-蛋白质化合物在调节蛋白质功能,细胞代谢和实现血管扩张,血小板抑制,非血管平滑肌松弛以及通过血红蛋白和肌红蛋白增加血氧输送方面的治疗用途.这些化合物还用于以其最生物活性形式释放一氧化氮,以实现上述效果,或者用于体外对体内分子进行亚硝基化.该发明还涉及对蛋白质和氨基酸上存在的氧,碳和氮基团进行亚硝基化,以实现上述生理效应.

专利信息

专利号:US-12421534-B2
优先权日:2021-11-10
标 题 :Engineered enzymes and method for the synthesis of diverse tyrosine analogs
发明人：ALMHJELL PATRICK J; ARNOLD FRANCES H
权利人:CALIFORNIA INST OF TECHN
摘要:Provided herein is an engineered tryptophan synthase β-subunit (TrpB) that catalyzes the synthesis of tyrosine, tyrosine analogs, or salts thereof. Also provided herein are methods for preparing tyrosine, tyrosine analogs, or a salt thereof using the engineered TrpB described herein.

专利号:US-7301006-B2
优先权日:2002-07-16
标 题 :Methods and materials for the synthesis of modified peptides
发明人：YOUNG TRAVIS G; KIESSLING LAURA L
权利人:WISCONSIN ALUMNI RES FOUND
摘要:Methods and protected amino acids useful as building blocks (protected monomers) for the synthesis of peptides and proteins that are selectively modified at one or more side-chain hydroxyl groups. Azide-bearing protecting groups allow the selective deprotection of side-chain hydroxyl groups of amino acids after synthesis of a peptide. Reaction conditions for removal of the azide-bearing protecting group can be selected which are substantially orthogonal to those that will remove α-amino protecting groups typically employed in peptide synthesis, such that hydroxyl groups protected with the azide-bearing protecting group remain protected during synthesis of the peptide chain. Various protecting groups which are readily available can be used for protecting potentially reactive side chain groups of amino acids in the peptide or protein to be modified. Preferred side-chain protecting groups are chemically distinguishable from the azide-bearing protecting group and substantially orthogonal reaction conditions can be selected such that side-chain protection of other amino acids is maintained when the azide-bearing protecting group is removed. The use of the azide-bearing protecting group of this invention for one or more hydroxy amino acids during peptide synthesis allows the selective unmasking of those azide-protected side-chain hydroxyl groups and selective modification of the hydroxyl groups that are selectively unmasked. The methods and materials herein are particularly used in synthesis of sulfated, phosphorylated and glycosylated peptides and proteins. Kits and methods of synthesizing a modified peptide or protein using the kits are also provided.

专利号:US-6350595-B1
优先权日:1997-10-28
标题:Synthesis of polynucleotides having random sequences
发明人：NEUNER PHILIPPE
权利人:ISTITUTO DI RICERCHE DI MOLECO
摘要:Subject of this invention is a process for the chemical synthesis of polynucleotides having totally or partially random sequences, based on the utilization, as synthesis monomer units for the random sequence part, or presynthesized mononucleotides and dinucleotides. Said synthesis is carried out on separate supports, so that on each of those supports is alternated at least one reaction cycle wherein a mixture of said dinucleotides is bound, with at least one reaction cycle wherein a mononucleotide is bound, and that in a preferred embodiment at the end of the n cycles required for a codon synthesis, the supports are mixed and then redivided into one or more reaction containers. The resulting polynucleotides are such that, for the random sequence part, each trinucleotide unit is fit to match only a limited number of codons, predefined for each unity in number and sequence, and the genetic code degeneracy effects can thus be eliminated. FIG. 1 shows the chemical structure of the dinucleotides utilized as monomer units for the synthesis of codons forming the final sequence.

专利号:WO-9312076-A1
优先权日:1991-12-13
标题:Reagents for automated synthesis of peptide analogs
发明人：WEBB THOMAS ROY
权利人:CORVAS INT INC
摘要:Reagents suitable for synthesis of peptide analogs using automated peptide synthesis and procedures for synthesis of peptide analogs are provided.

专利号:US-5283293-A
优先权日:1990-12-14
标 题:Reagents for automated synthesis of peptide analogs
发明人：WEBB THOMAS R
权利人:CORVAS INC
摘要:Reagents suitable for synthesis of peptide analogs using automated peptide synthesis and procedures for synthesis of peptide analogs are provided.

专利号:US-2010279334-A1
优先权日:2007-10-31
标题 :Cyclodipeptide synthases (cdss) and their use in the synthesis of linear dipeptides
发明人：SAUGUET LUDOVIC; THAI ROBERT; BELIN PASCAL; LECOQ ALAIN; GENET ROGER; PERNODET JEAN-LUC; GONDRY MURIEL
权利人:KYOWA HAKKO BIO CO LTD; CENTRE NAT RECH SCIENT; UNIV PARIS SUD 11; COMMISSARIAT ENERGIE ATOMIQUE
摘要:Use of CDSs in the synthesis of linear dipeptides, and applications thereof for the in vivo and in vitro synthesis of linear dipeptides, in particular Phe-Leu, Leu-Phe, Phe-Phe, Phe-Tyr, Tyr-Phe, Leu-Leu, Leu-Tyr, Tyr-Leu, Phe-Met, Met-Phe, Leu-Met, Met-Leu, Tyr-Met, Met-Tyr, Met-Met, Tyr-Tyr, Ile-Met, Met-Ile, Leu-Ile, Ile-Leu using the corresponding polynucleotides.