三唑酮置于concentrated Aqueous Hydrochloric Acid,Sodium Borohydrid,碳酸氢钠体系中,用 甲醇,水 作为反应溶剂,化学反应生成 三唑醇 参考文献:Antimicrobial Agents And Their Use 标题:Antimicrobial Agents And Their Use 摘要:本发明涉及提供含有3,3-二烷基或3-芳基-苯氧-1-(1,2,4-三唑-1-基)-和(咪唑-1-基-烷基-2-醇)醚的组合物,这些组合物特别有效地作为抗微生物特别是抗真菌剂.本发明还包括使用该组合物提供抗微生物,特别是抗真菌效果.
专利号:US-4751312-A 优先权日:1984-07-20 标 题:Process and intermediates for the synthesis of diastereomeric compounds 发明人:GASTEIGER JOHANN; KAUFMANN KARLHEINZ; MENGEL RUDOLF 权利人:BAYER AG 摘要:A new process for the controlled synthesis of the two diasteromeric forms of triazolyl-O,N-acetals of the formula (I) in which R represents optionally substituted phenyl, optionally substituted phenoxy, optionally substituted alkoxy, optionally substituted alkoxy, optionally substituted alkylthio, alkylcarbonyl, nitro or halogen and n represents an integer from 0 to 5, with the proviso that R can represent identical or different radicals, if n represents an integer from 2 to 5. New trans-substituted oxiranes and their use as intermediates for the synthesis of compounds of the formula (I).
专利号:US-5662898-A 优先权日:1990-08-20 标 题 :Genes for the synthesis of antipathogenic substances 发明人:LIGON JAMES M; HILL DWIGHT STEVEN; LAM STEPHEN TING; HAMMER PHILIP E 权利人:CIBA GEIGY CORP 摘要:The present invention is directed to the production of an antipathogenic substance (APS) in a host via recombinant expression of the polypeptides needed to biologically synthesize the APS. Genes encoding polypeptides necessary to produce particular antipathogenic substances are provided, along with methods for identifying and isolating genes needed to recombinantly biosynthesize any desired APS. The cloned genes may be transformed and expressed in a desired host organisms to produce the APS according to the invention for a variety of purposes, including protecting the host from a pathogen, developing the host as a biocontrol agent, and producing large, uniform amounts of the APS.
专利号:WO-2025056767-A1 优先权日:2023-09-15 标题 :Process for the preparation of enantiomerically enriched aliphatic amines 发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS 权利人:SYNGENTA CROP PROTECTION AG 摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.
专利号:US-2016073631-A1 优先权日:2013-03-04 标 题 :Process for the preparation of dihydropyrrole derivatives 发明人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS 权利人:SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD 摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) n n n n n n n n n n n n wherein n P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; n R 1 is chlorodifluoromethyl or trifluoromethyl; n R 2 is optionally substituted aryl or optionally substituted heteroaryl; n n is 0 or 1; n including the process comprising n (a-i) reacting a compound of formula II n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; n with nitromethane in the presence a chiral catalyst to give a compound of formula III n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; and n (a-ii) reductively cyclising the compound of formula III to give the compound of formula I. n n n n n The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).
专利号:US-9233920-B2 优先权日:2010-06-11 标题 :Process for the preparation of dihydropyrrole derivatives 发明人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS 权利人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS; SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD 摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) wherein P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; R 1 is chlorodifluoromethyl or trifluoromethyl; R 2 is optionally substituted aryl or optionally substituted heteroaryl; n is 0 or 1; including the process comprising (a-i) reacting a compound of formula II wherein P, R 1 and R 2 are as defined for the compound of formula I; with nitromethane in the presence a chiral catalyst to give a compound of formula III Wherein P, R 1 and R 2 are as defined for the compound of formula I; and (a-ii) reductively cyclizing the compound of formula III to give the compound of formula I. The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).
专利号:US-10906880-B2 优先权日:2016-01-26 标题:Kind of isothiazole oxime ether-containing strobilurin derivatives and its preparation methods and application 发明人:FAN ZHIJIN; CHEN LAI; GUO XIAOFENG; ZHU YUJIE; QIAN XIAOLIN; MA LIUYONG; ZHANG NAILOU; WANG HAIXIA; ZHANG ZHIMING; XU JINGHUA; SONG YINQI 权利人:UNIV NANKAI 摘要:The present invention is that provided a synthesis method of a series of isothiazole oxime ether containing strobilurin derivatives IV. The present invention relates to 3,4-dichloroisothiazolyl oxime ether strobilurin derivatives, and their chemical structural formula is as shown by IV. n n n n n n n n n n The invention discloses the structural formula of the above compound, the synthesis method and the use as an insecticide, a fungicide, an anti-plant virus agent, and an agriculturally acceptable auxiliary or synergist and a commercial insecticide. The use of a fungicide, an anti-plant virus agent and an acaricide in combination for controlling agricultural, forestry, horticultural plant pests, diseases, virus diseases and preparation methods.
1: Chu SH, Liao PH, Chen PJ. Developmental exposures to an azole fungicide triadimenol at environmentally relevant concentrations cause reproductive dysfunction in females of medaka fish. Chemosphere. 2016 Jun;152:181-9. doi: 10.1016/j.chemosphere.2016.02.078. Epub 2016 Mar 9. doi: 10.1007/s00216-015-9046-y. Epub 2015 Sep 28. doi: 10.1016/j.ecoenv.2014.06.021. Epub 2014 Jul 8. doi: 10.1002/elps.201300607. Epub 2014 Mar 26. doi: 10.1016/j.jhazmat.2013.11.055. Epub 2013 Dec 1. doi: 10.1016/j.jhazmat.2013.06.046. Epub 2013 Jun 27. doi: 10.1002/chir.22175. Epub 2013 May 9. doi: 10.1016/j.saa.2012.08.002. Epub 2012 Aug 16. doi: 10.1016/j.aca.2012.01.007. Epub 2012 Jan 12. doi: 10.1002/jssc.201100365. Epub 2011 Nov 21. doi: 10.1016/j.toxlet.2011.05.1036. Epub 2011 May 27. doi: 10.1021/es103430s. Epub 2011 Feb 22. doi: 10.1002/jssc.200900012. doi: 10.1002/chir.20715. Chinese. doi: 10.1021/tx800211t. Epub 2008 Sep 3. Epub 2007 Mar 22.
合成参考文献
参考文献:10.1371/journal.pone.0021403 摘要:Limpert E, Stahel WA. Problems with Using the Normal Distribution – and Ways to Improve Quality and Efficiency of Data Analysis. PLoS ONE. 2011 Jul 14;6(7):e21403. doi: 10.1371/journal.pone.0021403.