CAS: 55219-65-3; Triadimenol

该化合物是一种属于三硝基甲醇等级的系统性杀真菌剂,主要用于农业,以控制作物中各种真菌疾病;其化学结构具有三甲联苯环特征,这对行动方式至关重要,抑制了真菌细胞膜膜的基本成分 ----egosterol的合成;这种干扰导致病原菌菌的生长抑制;三甲联苯醇通常适用于谷物,水果和蔬菜等作物,并因其对粉末和叶片点等疾病的效力而闻名;该物质的特点是对哺乳动物的中度至低毒性,使其在应用时相对安全;然而,必须谨慎地处理,因为它可能对水生生物构成危险,并可能对环境产生影响;在环境中的持久性各不相同,而且要遵守有关其使用和应用的条例,以确保农业做法的安全和有效性.

结构式图片

欧盟法规

统一分类与标签REACH注册ECHA物质食品接触材料-禁用CMR物质欧盟农药活性物质OtherC&L通报REACH预注册废弃物危险特性清单"欧盟管控危险化学品"工作场所安全标识要求ECHA物质化妆品禁用物质清单

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CAS号43121-43-3 三唑酮 | CAS号7664-93-9 硫酸 | CAS号555-31-7 异丙醇铝

合成工艺路线路线简述

    三唑酮置于concentrated Aqueous Hydrochloric Acid,Sodium Borohydrid,碳酸氢钠体系中,用 甲醇,水 作为反应溶剂,化学反应生成 三唑醇
    参考文献:Antimicrobial Agents And Their Use
    标题:Antimicrobial Agents And Their Use
    摘要:本发明涉及提供含有3,3-二烷基或3-芳基-苯氧-1-(1,2,4-三唑-1-基)-和(咪唑-1-基-烷基-2-醇)醚的组合物,这些组合物特别有效地作为抗微生物特别是抗真菌剂.本发明还包括使用该组合物提供抗微生物,特别是抗真菌效果.

    海关参考信息

    专利信息


    专利号:US-4751312-A
    优先权日:1984-07-20
    标 题:Process and intermediates for the synthesis of diastereomeric compounds
    发明人:GASTEIGER JOHANN; KAUFMANN KARLHEINZ; MENGEL RUDOLF
    权利人:BAYER AG
    摘要:A new process for the controlled synthesis of the two diasteromeric forms of triazolyl-O,N-acetals of the formula (I) in which R represents optionally substituted phenyl, optionally substituted phenoxy, optionally substituted alkoxy, optionally substituted alkoxy, optionally substituted alkylthio, alkylcarbonyl, nitro or halogen and n represents an integer from 0 to 5, with the proviso that R can represent identical or different radicals, if n represents an integer from 2 to 5. New trans-substituted oxiranes and their use as intermediates for the synthesis of compounds of the formula (I).

    专利号:US-5662898-A
    优先权日:1990-08-20
    标 题 :Genes for the synthesis of antipathogenic substances
    发明人:LIGON JAMES M; HILL DWIGHT STEVEN; LAM STEPHEN TING; HAMMER PHILIP E
    权利人:CIBA GEIGY CORP
    摘要:The present invention is directed to the production of an antipathogenic substance (APS) in a host via recombinant expression of the polypeptides needed to biologically synthesize the APS. Genes encoding polypeptides necessary to produce particular antipathogenic substances are provided, along with methods for identifying and isolating genes needed to recombinantly biosynthesize any desired APS. The cloned genes may be transformed and expressed in a desired host organisms to produce the APS according to the invention for a variety of purposes, including protecting the host from a pathogen, developing the host as a biocontrol agent, and producing large, uniform amounts of the APS.

    专利号:WO-2025056767-A1
    优先权日:2023-09-15
    标题 :Process for the preparation of enantiomerically enriched aliphatic amines
    发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS
    权利人:SYNGENTA CROP PROTECTION AG
    摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.

    专利号:US-2016073631-A1
    优先权日:2013-03-04
    标 题 :Process for the preparation of dihydropyrrole derivatives
    发明人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS
    权利人:SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD
    摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) n n n n n n n n n n n n wherein n P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; n R 1 is chlorodifluoromethyl or trifluoromethyl; n R 2 is optionally substituted aryl or optionally substituted heteroaryl; n n is 0 or 1; n including the process comprising n (a-i) reacting a compound of formula II n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; n with nitromethane in the presence a chiral catalyst to give a compound of formula III n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; and n (a-ii) reductively cyclising the compound of formula III to give the compound of formula I. n n n n n The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).

    专利号:US-9233920-B2
    优先权日:2010-06-11
    标题 :Process for the preparation of dihydropyrrole derivatives
    发明人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS
    权利人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS; SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD
    摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) wherein P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; R 1 is chlorodifluoromethyl or trifluoromethyl; R 2 is optionally substituted aryl or optionally substituted heteroaryl; n is 0 or 1; including the process comprising (a-i) reacting a compound of formula II wherein P, R 1 and R 2 are as defined for the compound of formula I; with nitromethane in the presence a chiral catalyst to give a compound of formula III Wherein P, R 1 and R 2 are as defined for the compound of formula I; and (a-ii) reductively cyclizing the compound of formula III to give the compound of formula I. The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).

    专利号:US-10906880-B2
    优先权日:2016-01-26
    标题:Kind of isothiazole oxime ether-containing strobilurin derivatives and its preparation methods and application
    发明人:FAN ZHIJIN; CHEN LAI; GUO XIAOFENG; ZHU YUJIE; QIAN XIAOLIN; MA LIUYONG; ZHANG NAILOU; WANG HAIXIA; ZHANG ZHIMING; XU JINGHUA; SONG YINQI
    权利人:UNIV NANKAI
    摘要:The present invention is that provided a synthesis method of a series of isothiazole oxime ether containing strobilurin derivatives IV. The present invention relates to 3,4-dichloroisothiazolyl oxime ether strobilurin derivatives, and their chemical structural formula is as shown by IV. n n n n n n n n n n The invention discloses the structural formula of the above compound, the synthesis method and the use as an insecticide, a fungicide, an anti-plant virus agent, and an agriculturally acceptable auxiliary or synergist and a commercial insecticide. The use of a fungicide, an anti-plant virus agent and an acaricide in combination for controlling agricultural, forestry, horticultural plant pests, diseases, virus diseases and preparation methods.
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    主要参考文献


    1: Chu SH, Liao PH, Chen PJ. Developmental exposures to an azole fungicide triadimenol at environmentally relevant concentrations cause reproductive dysfunction in females of medaka fish. Chemosphere. 2016 Jun;152:181-9. doi: 10.1016/j.chemosphere.2016.02.078. Epub 2016 Mar 9. doi: 10.1007/s00216-015-9046-y. Epub 2015 Sep 28. doi: 10.1016/j.ecoenv.2014.06.021. Epub 2014 Jul 8. doi: 10.1002/elps.201300607. Epub 2014 Mar 26. doi: 10.1016/j.jhazmat.2013.11.055. Epub 2013 Dec 1. doi: 10.1016/j.jhazmat.2013.06.046. Epub 2013 Jun 27. doi: 10.1002/chir.22175. Epub 2013 May 9. doi: 10.1016/j.saa.2012.08.002. Epub 2012 Aug 16. doi: 10.1016/j.aca.2012.01.007. Epub 2012 Jan 12. doi: 10.1002/jssc.201100365. Epub 2011 Nov 21. doi: 10.1016/j.toxlet.2011.05.1036. Epub 2011 May 27. doi: 10.1021/es103430s. Epub 2011 Feb 22. doi: 10.1002/jssc.200900012. doi: 10.1002/chir.20715. Chinese. doi: 10.1021/tx800211t. Epub 2008 Sep 3. Epub 2007 Mar 22.

    合成参考文献


    参考文献:10.1371/journal.pone.0021403
    摘要:Limpert E, Stahel WA. Problems with Using the Normal Distribution – and Ways to Improve Quality and Efficiency of Data Analysis. PLoS ONE. 2011 Jul 14;6(7):e21403. doi: 10.1371/journal.pone.0021403.
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