CAS: 521-62-0; 1,8-Dihydroxy-3-Methyl-6-(((2S,3R,4R,5R,6S)-3,4,5-Trihydroxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)Anthracene-9,10-Dione

上下游产品

1,8-di-O-n-hexanoyl-3-(2',4'-di-O-acetyl-3'-O-levulinyl-α-L-rhamnopyranosyl)emodinglucofranguline A

📜1,8-Di-O-N-Hexanoyl-3-(2',4'-Di-O-Acetyl-3'-O-Levulinyl-α-L-Rhamnopyranosyl)Emodin置于甲醇,Sodium Methylate体系中,用 二氯甲烷,甲醇 作为反应溶剂,化学反应 0.5H,以85.7%的收率获得产物泻鼠李皮苷a
参考文献:Synthesis And Biological Evaluation Of Cytotoxic Activity Of Novel Anthracene L-Rhamnopyranosides
标题:Synthesis And Biological Evaluation Of Cytotoxic Activity Of Novel Anthracene L-Rhamnopyranosides
摘要:A Series Of Anthracene L-Rhamnopyranosides Were Designed And Synthesized In A Practical Way And Their Cytotoxic Activity Was Examined In Vitro. Most Compounds Exhibited Both Potent Cytotoxicity Against Several Tumor Cell Lines And High Dna Binding Capacity. The Preliminary Results Showed That Subtle Modifications Of Rhamnosyl Moiety In Anthracene Rhamnosides With Acetyl Group Had A Selective Toxicity For Different Tumor Cells And The Displacement Of C-10 Carbonyl Group In Emodin By Acetylmethylene Group Was Helpful To Improve The Inhibitory Activity. Lipophilicity Of The Anthracene Glycosides Was Not A Crucial Factor For Cytotoxicity And Most Molecules With Good Cytotoxicity Could Inhibit The Catalytic Activity Of Top2 Alpha. (C) 2010 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmc.2010.05.064