CAS: 50675-20-2; Piperidine-4-Carbaldehyde

上下游产品

tert butyl 4-formylpiperidine-1-carboxylate 4-piperidinemethanol tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate 4-carbethoxypiperidine 8-bromo-2-{2-chloro-4-[(piperidin-4-ylmethyl)amino]phenyl}[1]benzofuro[3,2-d]pyrimidin-4(3H)-one 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-phenyl-1-piperidineacetic acid tert butyl 4-formylpiperidine-1-carboxylate

📜4-哌啶甲醇置于4-二甲氨基吡啶,2,2'-联吡啶,2-氮杂金刚烷-N-氧自由基,Copper(L) Chloride体系中,用 乙腈 作为反应溶剂,化学反应 1.5H,反应生成 哌啶-4-甲醛
参考文献:氨基醇的高度化学选择性好氧氧化成氨基羰基化合物
标题:氨基醇的高度化学选择性好氧氧化成氨基羰基化合物
摘要:未保护的氨基醇直接氧化成其相应的氨基羰基化合物经常在有机合成中面临严峻挑战,并限制了化学家采用间接路线(例如保护/脱保护策略)来实现其目标.本文描述了未保护的氨基醇对它们的氨基羰基化合物的高度化学选择性好氧氧化,其中使用了2-氮杂金刚烷n-氧基(azado)/铜催化.所开发的催化系统导致带有伯,仲或叔氨基的各种未保护氨基醇的醇选择性氧化,在环境温度下暴露于空气下具有非常好至高收率,从而为合成氮提供了灵活性.含有化合物.
DOI:10.1002/anie.201309634

专利信息

专利号:US-2007060558-A1
优先权日:2004-07-30
标 题 :Hybrid molecules QA where Q is an aminoquinoline and A is an antibiotic residue, the synthesis and uses thereof as antibacterial agents
发明人：SANCHEZ MURIEL; MEUNIER BERNARD
权利人:CENTRE NAT RECH SCIENT
摘要:The invention concerns an aminoquinoline-antibiotic hybrid compound of general formula (I): Q—(Y 1 ) p —(U) p —(Y 2 ) p -A: wherein Q represents an aminoquinoline, (Y 1 ) p (U) p —(Y 2 ) p″ is an optional spacer and A is an antibiotic residue. The invention enables the antibiotic residue activity to be unexpectedly enhanced.

专利号:WO-2012038966-A1
优先权日:2010-09-22
标 题 :Process for the preparation of donepezil intermediate
发明人：NARAYANA RAO MUTYALA; RAMADAS CHAVAKULA; SRINIVAS RAO CHENNUPATI; SANDEEP GOKARAJU
权利人:TYCHE IND LTD; NARAYANA RAO MUTYALA; RAMADAS CHAVAKULA; SRINIVAS RAO CHENNUPATI; SANDEEP GOKARAJU
摘要:This invention relates to a process for the preparation of N-benzyl-4- formylpiperidine (I), a key intermediate used in the synthesis Donepezil. The said process comprises the decomposition of sulfoxonium complex of formula (V) in the presence of base. The compound of formula (V) may be prepared by a method comprising reacting N-Benzyl-4-hydroxymethylpiperidine (II) with dimethylsulfide and N-chlorosuccinamide; or dimethylsulfide and N-bromosuccinamide; or dimethylsulfide and chlorine gas; or thioanisole and N-chlorosuccinamide; or thioanisole and N-bromosuccinamide in a suitable organic solvent.

专利号:US-8580822-B2
优先权日:2006-12-11
标 题:Compositions, synthesis, and methods of using indanone based cholinesterase inhibitors
发明人：BHAT LAXMINARAYAN; MOHAPATRA PRABHU PRASAD
权利人:BHAT LAXMINARAYAN; MOHAPATRA PRABHU PRASAD; REVIVA PHARMACEUTICALS INC
摘要:The present invention provides novel indanone derivatives which can be advantageously used for treating and/or preventing of a medical condition for which inhibition of a cholinesterase is desired.

专利号:CN-101492420-A
优先权日:2008-01-22
标 题 :Synthesis of whorl(1-tetrahydronaphthalene-4,4'-piperidine) derivative

专利号:US-7091360-B2
优先权日:2002-04-16
标 题:Process for preparing heteroaryl and unsaturated heterocycloalkylmagnesium reagents and uses thereof
发明人：LI JIAYAO; LINK JOHN O; COLLADANT COLETTE
权利人:AVENTIS PHARMA SA
摘要:The present invention is directed to a novel process for preparing heteroaryl and unsaturated heterocycloalkylmagnesium reagents that are useful in the synthesis of a variety of pharmaceuticals, in particular certain cysteine protease inhibitors.

专利号:CN-115785087-B
优先权日:2021-09-09
标 题:A method for the synthesis of monovalent gold-catalyzed 1H-pyrido[4,3-b]indole skeleton compounds