CAS: 490-83-5; (R)-5-((S)-1,2-Dihydroxyethyl)Furan-2,3,4(5H)-Trione

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CAS号50-81-7 抗坏血酸 | CAS号78619-96-2 Vitamin C | CAS号7732-18-5 水 | CAS号299-36-5 Ascorbic Acid | CAS号12125-80-3 cyclopenta-1,3-... | CAS号956-48-9 2,6-二氯靛酚 | CAS号7758-19-2 亚氯酸钠 | CAS号1668-08-2 L-半乳糖酸-1,4-内酯 | CAS号3240-34-4 碘苯二乙酸 | CAS号50-81-7 抗坏血酸 | CAS号74185-01-6 oxidized DTT | CAS号88-14-2 糠酸; 2-糠酸; 2-呋喃甲酸 | CAS号3566-57-2 3,4-二羟基-5-甲基-2-呋喃酮 | CAS号3445-22-5 2,3-二酮-L-古洛糖酸 | CAS号7306-96-9 L-Threonic Acid | CAS号144-62-7 草酸 | CAS号14040-77-8 N1,N2-DIPROPYLE... | CAS号81682-53-3 氧代(丙基氨基)乙酸

📜Sodium Ascorbate置于ruthenium体系中,用 Aq. Phosphate Buffer 作为反应溶剂,化学反应生成 脱氢抗坏血酸
参考文献:使用钌纳米材料模仿辣根过氧化物酶和氧化酶†
标题:使用钌纳米材料模仿辣根过氧化物酶和氧化酶†
摘要:尽管在研究基于贵金属的酶样催化剂方面已取得重要进展,但很少有人报道了模仿钌纳米颗粒(ru Nps)的酶的应用的报道.在这项工作中,我们研究了ru Nps的辣根过氧化物酶(hrp)和氧化酶模拟活性.模仿hrp,钌纳米颗粒可以催化底物的氧化3,3,5,5-四甲基联苯胺(tmb),ô苯二胺(opd)和盐酸多巴胺(da)在存在外源加入的h 2 ö 2以反应生成产品分别具有蓝色,黄色和橙色.我们还报告了第一个证据,表明ru Np具有内在的氧化酶样活性,可以催化tmb和l钠的氧化.溶解氧反应生成抗坏血酸(naa).发现ru Nps的hrp样和氧化酶样活性与ru Nps的浓度有关.通过电子自旋共振光谱法(esr)分析了催化机理,这表明ru Nps的酶模拟活性可能源于其加速底物与H2O 2或o 2之间电子转移的特性.我们的发现提供了对类似酶的ru Np的更好理解,并应为将来的应用提供重要的见识.
DOI:10.1039/c7Ra10370K

专利信息

专利号:US-2025214918-A1
优先权日:2022-05-20
标 题:Functionalization of terpenes by selective deprotonation for the synthesis of (+)-artemisinin and related compounds
发明人：FRANTZ DOUG E; BLUMBERG SHAWN; ORTIZ ELIEZER; CLANTON NICHOLAS; WILSON NICK
权利人:UNIV TEXAS
摘要:The present invention provides methods for the preparation of (+)-Artemisinin and intermediates thereof, including via the regioselective deprotonation of amorphadiene (AD). In other aspects, there are provided methods for the functionalization terpenes by selective deprotonation, including the utilization of 4,11-amorphadiene as an industrially viable feedstock for the synthesis of artemisinin. In some embodiments, these methods are broadly applicable to the derivatization of a variety of cyclic and linear terpenes.

专利号:US-2017348280-A1
优先权日:2016-06-06
标题 :Counteracting the inhibition of collagen synthesis by select calcium and sodium channel blockers using ascorbic acid and ascorbyl palmitate
发明人：RATH MATTHIAS W; NIEDZWIECKI ALEKSANDRA; IVANOV VADIM O; IVANOVA SVETLANA V
权利人:RATH MATTHIAS W; NIEDZWIECKI ALEKSANDRA; IVANOV VADIM O; IVANOVA SVETLANA V
摘要:A therapeutic use of ascorbyl palmitate, ascorbic acid and/or derivatives thereof to reverse or counter the adverse effects of channel blockers in the medical management of cardiovascular disease in a subject is presented. Effects of select Na- and Ca-channel blockers on collagen synthesis and deposition were evaluated in cultured human dermal fibroblasts and aortic smooth muscle cells by immunoassay. Ca and Na-channel blockers inhibited the synthesis of collagen type I and collagen type IV, the basic molecules of vascular wall stability. The inhibitory effects of the calcium and sodium channel blockers on collagen synthesis was reversed by introducing ascorbic acid and/or ascorbyl palmitate. It can be concluded that calcium and sodium channel blockers have a direct inhibitory effect on collagen synthesis, favoring the instability of the vascular wall and the progression of cardiovascular disease, an effect that is mitigated by treatment with, ascorbyl palmitate, ascorbic acid and or derivatives thereof.

专利号:US-2024132430-A1
优先权日:2021-08-05
标 题 :Chemicals and use of hypohalites in mechanism-based selective dual radical organic synthesis
发明人：PALOMINO EDUARDO
权利人:WALKER CANCER RES INSTITUTE INC
摘要:The synthesis of pattern-specific compounds using hypohalites, such as hypochlorous acid, sodium hypochlorite, and potassium hypoiodite, as dual-radical generators is provided. The synthesis can be implemented by a cyclization reaction, a dehydrogenation reaction, a hydroxylation reaction, a decarboxylation reaction, or any combination of the above four. The reactions are typically carried out in water, in a nonpolar solvent such as ethyl acetate, or a mixture of both. Hypochlorous acid is made by adding a weak acid such as acetic acid to sodium hypochlorite.

专利号:US-2025019350-A1
优先权日:2023-06-16
标题 :Synthesis of the prostate specific membrane antigen (psma) radiolabeled inhibitor [18f]dcfpyl
发明人：BENITES PEDRO; ROBINSON SIMON P; SIEGLER ROBERT W
权利人:PROGENICS PHARM INC
摘要:Provided herein are methods and related compositions, including kits, for the improved synthesis, preparation and/or storage of [18F]DCFPyL. Also provided are methods of using [18F]DCFPyL, such as for imaging.

专利号:US-2003068317-A1
优先权日:2001-04-20
标题:High capacity methods for separation, purification, concentration, immobilization and synthesis of compounds and applications based thereupon
发明人：LEE WILLIAM; SAITO KYOICHI
摘要:Compositions are provided herein comprising a base material having engrafted polymer brushes. The polymer brushes further comprise one or more functional groups immobilized along the surface of the brushes in a plurality of layers, which confer functional properties to the base material compositions. Methods of using these compositions include deoxygenation of a sample solution, hydrolysis of denaturing agents in a sample solution, resolution of racemic mixtures in a sample solution, and purification, and concentration of target compounds.

专利号:US-11633492-B2
优先权日:2017-11-24
标题 :Process for the synthesis of linker-drug vc-seco-DUBA
发明人：JANOUSEK VLADIMIR; KAS MARTIN
权利人:BYONDIS BV
摘要:The compound of formula (II) is an advantageous intermediate for improving the process of synthesizing the linker-drug vc-seco-DUBA, as well as for the overall process for preparing an antibody-drug conjugate comprising the vc-seco-DUBA linker-drug. The methods of making the compound of formula (II) can include recovery of the compound as a solid, such as via crystallization, in high yields and purity.