CAS: 482-28-0; (+)-Cinchonamine

📜邻甲苯胺置于三甲基氯硅烷 甲基碘化镁,正丁基锂,氧化环己烯,Lithium Iodide体系中,用 Neat (No Solvent) 作为反应溶剂,化学反应 29.75H,反应生成 金鸡纳胺
参考文献:合成中的有机金属试剂:构建吲哚核的新方案
标题:合成中的有机金属试剂:构建吲哚核的新方案
摘要:衍生自2-烷基-N-三甲基甲硅烷基苯胺的有机二锂试剂与羧酸酯缩合,得到取代的吲哚.总共报告了16个示例;总体上来说是好的.结合该程序,还开发了一种方便,大规模的制备单硅烷化苯胺的方法.为了证明新吲哚方案在天然产物合成中的实用性,在区域和立体选择性上完成了(+)-金鸡胺和(+)-表-金鸡胺的有效合成,以及建筑复杂的阴茎霉菌毒素的四环模型系统.时尚.
DOI:10.1016/s0040-4020(01)90586-1

专利信息

专利号:US-5900227-A
优先权日:1996-06-17
标题 :Multicyclic nitrone spin trapping compositions
发明人：JANZEN EDWARD G; SANKURATRI NAGARAJU
权利人:OKLAHOMA MED RES FOUND
摘要:Multicyclic nitrone spin trapping compounds capable of forming stable free radical spin adducts are provided as well as methods for their synthesis. The multicyclic nitrone spin trapping compounds can be reacted with a free radical, such as a hydroxy or hydroperoxy radical, in solution to form a spin adduct which is stable and readily detectable by electron paramagnetic resonance (EPR) spectroscopy. The multicyclic nitrone spin traps can be used to detect free radicals in a sample such as a biological system. In one embodiment, the spin trapping compound, 1,3,3-trimethyl-6-azabicyclo-[3.2.1]oct-6-ene-N-oxide ('TRAZON') is provided, as well as methods for the synthesis of TRAZON and of modified forms of TRAZON. TRAZON can react with a wide range of different free radicals in solution to form free radical spin adducts which are readily detectable by EPR.