📜2-溴-3-氨基吡啶置于cucn体系中,化学反应生成 3-氨基-2-氰基吡啶 参考文献:Berrie Et Al.,Journal Of The Chemical Society,1952,P. 2042,2044 标题:Berrie Et Al.,Journal Of The Chemical Society,1952,P. 2042,2044
专利号:US-3950160-A 优先权日:1972-09-27 标题:Inhibiting the growth of weeds with 2-substituted pyrdidopyimidines and salts thereof 发明人:ABU EL-HAJ MARWAN J; DOMINY BERYL WILLIAM 权利人:PFIZER 摘要:2-Substituted pyridopyrimidines and their alkali and alkylamine salts as herbicides, and processes for the synthesis of starting materials leading to the preparation thereof.
专利号:US-3962264-A 优先权日:1972-09-27 标 题:Process for making 2-amino nicotinonitrile 发明人:ABU EL-HAJ MARWAN J; DOMINY BERYL WILLIAM 权利人:PFIZER 摘要:2-Substituted pyridopyrimidines and their alkali and alkylamine salts as herbicides, and processes for the synthesis of starting materials leading to the preparation thereof.
专利号:US-3917624-A 优先权日:1972-09-27 标题:Process for producing 2-amino-nicotinonitrile intermediates 发明人:ABU EL-HAJ MARWAN J; DOMINY BERYL WILLIAM 权利人:PFIZER 摘要:2-Substituted pyridopyrimidines and their alkali and alkylamine salts as herbicides, and processes for the synthesis of starting materials leading to the preparation thereof.
专利号:US-3862191-A 优先权日:1972-09-27 标 题 :Pyrido{8 2,3-d{9 pyrimidin-4(3H)-one 发明人:EL-HAJ MARWAN J ABU; DOMINY BERYL WILLIAM 权利人:PFIZER 摘要:2-Substituted pyridopyrimidines and their alkali and alkylamine salts as herbicides, and processes for the synthesis of starting materials leading to the preparation thereof.
专利号:US-9695191-B2 优先权日:2009-08-05 标题 :Conformationally constrained, fully synthetic macrocyclic compounds 发明人:OBRECHT DANIEL; ERMERT PHILIPP; OUMOUCH SAID; LACH FRANCK; LUTHER ANATOL; MARX KARSTEN; MÖHLE KERSTIN 权利人:OBRECHT DANIEL; ERMERT PHILIPP; OUMOUCH SAID; LACH FRANCK; LUTHER ANATOL; MARX KARSTEN; MÖHLE KERSTIN; POLYPHOR AG 摘要:Conformationally restricted, spatially defined 12-30 membered macrocyclic ring systems of type (I) are constituted by three distinct building blocks: an aromatic template a, a conformation modulator b and a spacer moiety c as detailed in the description and the claims. Macrocycles of type (I) are readily manufactured by parallel synthesis or combinatorial chemistry. They are designed to interact with specific biological targets. In particular, they show agonistic or antagonistic activity on the motilin receptor (MR receptor), on the serotonin receptor of subtype 5-HT 2B (5-HT 2B receptor), and on the prostaglandin F2•receptor (FP receptor). They are thus potentially useful for the treatment of hypomotility disorders of the gastrointestinal tract such as diabetic gastroparesis and constipation type irritable bowl syndrome; of CNS related diseases like migraine, schizophrenia, psychosis or depression; of ocular hypertension such as associated with glaucoma and preterm labour.
专利号:CN-116444527-A 优先权日:2023-03-30 标题 :A high-efficiency construction method of fused tricyclic skeleton and the synthesis method of its energetic derivatives