CAS: 41964-07-2; 5-(M-Tolyloxy)Pyrimidin-2(1H)-One

该化合物是一种化学化合物,其特点是以3-甲基苯氧基组替代了丙米丁酮核心,该结构表明,该化合物具有芳香和异环特性,可影响其化学反应和生物活动.该亚米丁酮的出现表明其在药用化学中的潜在应用,因为正米丁衍生物经常因其药理特性而被探索.3-甲基苯氧代谢分属可能增强脂性,有可能影响该化合物的溶性及渗透性.此外,该化合物可能与生物目标产生具体互动,使其对......

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合成工艺路线路线简述

    📜1-(2,2-二甲氧基乙氧基)-3-甲基苯置于sodium Ethanolate,溶剂黄146,尿素,三氯氧磷体系中,用 乙醇,氯仿,水 作为反应溶剂,化学反应 8.0H,反应生成 托利咪酮
    参考文献:톨리미돈의 대량 제조 방법
    标题:톨리미돈의 대량 제조 방법
    摘要:该专利涉及一种用于大规模生产高纯度和均匀粒度分布的托利米酮(Tolimidone)的方法,更详细地说,通过使用四丁基溴化铵催化剂和乙醇再结晶,可以在比传统技术更短的时间内生产高纯度的托利米酮,并且可以保持水含量和粒度分布稳定,适用于工业大规模生产的方法.

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    专利信息


    专利号:US-2014315720-A1
    优先权日:2012-10-24
    标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
    发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
    权利人:CELANESE ACETATE LLC
    摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

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    主要参考文献


    1: Apolzan JW, LaRose JG, Anton SD, Beyl RA, Greenway FL, Wickham EP 3rd, Lanoye A, Harris MN, Martin CK, Bullard T, Foster GD, Cardel MI. A scalable, virtual weight management program tailored for adults with type 2 diabetes: effects on glycemic control. Nutr Diabetes. 2023 Apr 6;13(1):3. doi: 10.1038/s41387-023-00234-6.
    2: Rebello CJ, Coulter AA, Reaume AG, Cong W, Cusimano LA, Greenway FL. MLR-1023 Treatment in Mice and Humans Induces a Thermogenic Program, and Menthol Potentiates the Effect. Pharmaceuticals (Basel). 2021 Nov 22;14(11):1196. doi: 10.3390/ph14111196.
    3: Lipinski CA, Reaume AG. High throughput in vivo phenotypic screening for drug repurposing: Discovery of MLR-1023 a novel insulin sensitizer and novel Lyn kinase activator with clinical proof of concept. Bioorg Med Chem. 2020 May 1;28(9):115425. doi: 10.1016/j.bmc.2020.115425. Epub 2020 Mar 16. 34(5):107555. doi: 10.1016/j.jdiacomp.2020.107555. Epub 2020 Feb 2.

    合成参考文献


    参考文献:10.1007/978-981-15-8791-7_2
    摘要:Chen H, Lu Y. An Overview of Hypoglycemic Modern Drugs. 2021. In: Structure and Health Effects of Natural Products on Diabetes Mellitus.
    参考文献:10.1007/978-981-16-9232-1_5
    摘要:Farouk IA, Low ZY, Puniyamurti A, Zabidi NZ, Amin MKA, Lal SK. Genomic Approaches for Drug Repositioning. 2022. In: Biomedical Translational Research.
    参考文献:10.1124/mol.119.115964
    摘要:Lee TD, Lee OW, Brimacombe KR, Chen L, Guha R, Lusvarghi S, Tebase BG, Klumpp-Thomas C, Robey RW, Ambudkar SV, Shen M, Gottesman MM, Hall MD. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular Pharmacology. 2019 Nov;96(5):629–40. doi: 10.1124/mol.119.115964.
    参考文献:10.1007/978-981-97-2776-6_9
    摘要:Kaur A, Chakraverty R, Mathur R. Hormones and Hormones Antagonists. 2024. In: Essentials of Pharmacodynamics and Drug Action.
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