CAS: 404-86-4; (E)-N-(4-Hydroxy-3-Methoxybenzyl)-8-Methylnon-6-Enamide

上下游产品

CAS号1196-92-5 4-(氨基甲基)-2-甲氧基苯酚 | CAS号95636-02-5 反-8-甲基-6-壬酰氯 | CAS号59320-77-3 8-甲基壬-6-烯酸 | CAS号112375-54-9 (6E)-8-甲基--6-壬烯... | CAS号50889-29-7 5-羧基戊基-三苯基溴化磷 | CAS号59721-82-3 (E)-1-hydroxy-6... | CAS号121-33-5 香草醛 | CAS号31467-60-4 (6Z)-8-甲基-6-壬烯酸 | CAS号502-44-3 ε-己内酯 | CAS号6654-36-0 6-氧代己酸甲酯 | CAS号19408-84-5 二氢辣椒素 | CAS号5129-54-4 8-甲基壬酸甲酯 | CAS号5129-53-3 7-甲基辛酸甲酯 | CAS号112375-54-9 (6E)-8-甲基--6-壬烯...

(E)-6-Methylhept-4-En-1-Ol置于sodium Hydroxide,氯化亚砜,Sodium Hydride,二甲基亚砜,三乙胺,Potassium Iodide,Sodium Chloride体系中,用 甲醇,乙醚,二氯甲烷,水 作为反应溶剂,化学反应 27.25H,反应生成 辣椒碱
参考文献:通过原酸酯克莱森重排进行辣椒素类化合物的一般和立体选择性合成
标题:通过原酸酯克莱森重排进行辣椒素类化合物的一般和立体选择性合成
摘要:辣椒素是辣椒的主要辛辣成分,它的15种类似物已得到有效合成.这种合成的sheme的关键步骤是原酸酯claisen重排,它以高度立体选择性的方式将烯丙醇2A-C转变为(e)-链烯酸酯3A-C().随后的基于氰化或丙二酸酯合成的碳链在3上的延伸得到(e)-链烯酸8,将其转化为相应的酰氯,然后与香草醛偶联以得到辣椒素.还对这些辣椒素进行了HPLC和ce(毛细管电泳)分析.
DOI:10.1016/0040-4020(96)00414-0

专利信息

专利号:WO-2021014395-A1
优先权日:2019-07-24
标题:Process for the synthesis of deuterated capsaicin, capsaicinoids and synthetic capsaicin analogs
发明人：ORUGANTI SRINIVAS; AMRUTAPU SRAVANTH KUMAR; SAMPATH MAGESH; SEN SAIKAT
权利人:DR REDDY’S INST OF LIFE SCIENCES
摘要:The present application provides novel processes for the synthesis of deuterated intermediates of capsaicinoids, particularly II, III, IV and V of capsaicinoids, relating to pharmaceutical applications. The invention also provides novel intermediates of compounds of formula IX, XIV, XV, XVI, XVII, XVIII, XX and XXI utilized in the process of making deuterated capsaicin II, III, IV and V.

专利号:US-10308588-B2
优先权日:2014-12-15
标 题 :Synthesis of amides and amines from aldehydes or ketones by heterogeneous metal catalysis
发明人：CÓRDOVA ARMANDO; PALO-NIETO CARLOS; AFEWERKI SAMSON
权利人:ORGANOFUEL SWEDEN AB
摘要:A mild and efficient synthesis of primary amines and amides from aldehydes or ketones using a heterogeneous metal catalyst and amine donor is disclosed. The initial heterogeneous metal-catalyzed reaction between the carbonyl and the amine donor components is followed by the addition of a suitable acylating agent component in one-pot, thus providing a catalytic one-pot three-component synthesis of amides. Integration of enzyme catalysis allows for eco-friendly one-pot co-catalytic synthesis of amides from aldehyde and ketone substrates, respectively. The process can be applied to asymmetric synthesis or to the co-catalytic one-pot three-component synthesis of capsaicin and its analogues from vanillin or vanillyl alcohol. A co-catalytic reductive amination/dynamic kinetic resolution (dkr) relay sequence for the asymmetric synthesis of optically active amides from ketones is disclosed. Implementation of a catalytic reductive amination/kinetic resolution (kr) relay sequence produces the corresponding optically active amide product and optical active primary amine product with the opposite stereochemistry from the starting ketones.

专利号:US-11891351-B2
优先权日:2020-03-20
标 题 :Synthesis of capsaicin derivatives
发明人：LAGER ERIK
权利人:AXICHEM AS
摘要:The present invention relates to the synthesis of capsaicin derivatives, specifically to the synthesis of 6-heptyne derivatives of capsaicin.

专利号:US-11168050-B2
优先权日:2014-03-27
标 题 :Efficient synthesis of amines and amides from alcohols and aldehydes by using cascade catalysis
发明人：CÓRDOVA ARMANDO; BERGLUND PER; ANDERSON MATTIAS; AFEWERKI SAMSON
权利人:XP CHEMISTRIES AB
摘要:The present invention relates generally to an eco-friendly methodology for the conversion of alcohols and aldehydes to amines and amides using an integrated enzyme cascade system with metal- and organocatalysis. More specifically, the present invention relates to synthesis of capsaicinoids starting from vanillin alcohol and using a combination of an enzyme cascade system and catalysts. Furthermore, the method also relates to synthesis of capsaicinoids derivatives starting from vanillin alcohol derivatives and using a combination of an enzyme cascade system and catalysts.

专利号:WO-2016171538-A1
优先权日:2015-04-22
标 题 :Enzymatic-chemical method for the synthesis of vanillylamides of organic acids
发明人：TORRES GAVILÃ?N ALEJANDRO; REGLA CONTRERAS JOSÉ IGNACIO; CASTILLO ROSALES EDMUNDO; LÓPEZ-MUNGUÃ?A CANALES AGUSTÃ?N
权利人:UNIV NAC AUTÓNOMA DE MÉXICO
摘要:The invention relates to a method for synthesising vanillylamides of organic acids, based on vanillin oxime, inorganic salts of vanillylamine or based on organic salts of vanillylamine having organic acids. The method involves: the chemical synthesis of vanillylamine organic salts based on the hydrogenation of the vanillin oxime in the presence of an organic acid; the release of vanillylamine inorganic salts in the presence of a base or carbonate and an organic acid; and an enzymatic condensation of the two elements that form the organic salt, the vanillylamine and the organic acid, in order to bring about the synthesis of organic acid vanillylamides. The organic acid used for the reaction can be any organic acid: natural or synthetic, saturated, linear or branched, having substituents such as hydroxyl groups or others. The reactions can be carried out independently or in sequence. These capsaicinoid compounds, components similar to capsaicin or vanillylamides can be used as a pungent material, irritant, in pharmaceutical products, as additives in food, in cosmetics, among others.

专利号:US-11912647-B2
优先权日:2020-05-22
标 题:Diversity-oriented synthesis of N,N,O-trisubstituted hydroxylamines from alcohols and amines by N—O bond formation
发明人：CRICH DAVID; HETTIKANKANAMALAGE ASIRI; HILL JARVIS
权利人:UNIV GEORGIA
摘要:In one aspect, the disclosure relates to a method for the direct synthesis of complex N,N,O-trisubstituted hydroxylamines by N—O bond formation. In another aspect, the method can successfully be employed using a wide variety of commercially available alcohols and secondary amines and enables the construction of large fragment-based libraries of trisubstituted hydroxylamines for drug discovery purposes. Also disclosed are N,N,O-trisubstituted hydroxylamines having low basicity, high stability at ambient temperatures, and an inherent lack of reactivity towards acetylating and sulfonylating enzymes that confer mutagenicity on less-substituted hydroxylamines.