CAS: 342-69-8; 6-Methylmercaptopurine Riboside

相似化合物

550-33-4 574-25-4 1867-73-8

上下游产品

CAS号5188-07-8 甲硫醇钠 | CAS号7387-57-7 2',3',5'-三乙酰腺苷 | CAS号58-61-7 腺苷 | CAS号163632-54-0 9-(β-D-ribofura... | CAS号66782-10-3 tri-O-benzoyl-1... | CAS号74-88-4 碘甲烷 | CAS号6974-32-9 1-乙酰氧基-2,3,5-三苯... | CAS号50-66-8 6-甲巯基嘌呤 | CAS号73237-86-2 (2R,3R,4R,5R)-2... | CAS号50-66-8 6-甲巯基嘌呤 | CAS号18646-11-2 α-D-ribofuranos... | CAS号4338-47-0 激动素核苷 | CAS号58-61-7 腺苷 | CAS号23526-11-6 Inosine,2'-deox... | CAS号42021-78-3 [7,7-dimethyl-2... | CAS号132154-36-0 N-(9-β-D-ribofu... | CAS号4542-23-8 Succinyladenosine | CAS号53665-01-3 2-(6-aziridin-1...

📜2',3',5'-三乙酰腺苷置于氨 二碘甲烷,亚硝酸正戊酯体系中,用 乙醇,乙腈 作为反应溶剂,化学反应 37.0H,反应生成 6-甲硫基嘌呤核苷
参考文献:Photoinduced Alkylthiolation Of Halogenated Purine Nucleosides
标题:Photoinduced Alkylthiolation Of Halogenated Purine Nucleosides
摘要:描述了一种新的高效合成生物重要的甲基巯基嘌呤核苷的方法.该方法相较于早期报道的此类化合物的合成方法,具有显著的改进.
DOI:10.1055/s-1986-31672

专利信息

专利号:US-11858953-B2
优先权日:2018-04-04
标 题:Compositions and methods for synthesis of phosphorylated molecules
发明人：CHAPUT JOHN; LIAO JEN-YU; BALA SAIKAT
权利人:UNIV CALIFORNIA
摘要:The invention provides compositions and methods for synthesis of phosphorylated organic compounds, including nucleoside triphosphates.

专利号:US-2005080260-A1
优先权日:2003-04-22
标 题 :Preparation of prodrugs for selective drug delivery
发明人：MILLS RANDELL L; WU GUO-ZHANG
摘要:Synthesis of a chemical compound having the formula A-B-C that may serve for applications such as drug delivery where A is a chemiluminescent, moiety, B is a photochromic moiety, and C is a biologically active moiety where A-B-C may serve as a prodrug. Novel synthetic methods of the present invention to form the prodrug comprised the steps of (1) forming a benzophenone, (2) forming a diaryl ethylene, (3) attaching a phthalimide moiety to at least one of the aryl groups of the ethylene to form a phthalimide-ethylene conjugate, (4) condensing two ethylene-phthalimide conjugates to form a phthalimide-pentadiene conjugate, (5) converting the phthalimide to the phthalhydrazide by reaction with hydrazine to form a carrier compound according to the present invention, and (6) reacting the carrier compound with an nucleophilic moiety of the drug to form the corresponding prodrug. Alternatively the carrier can be prepared by using the halo-substituted diaryl ethylene to make the corresponding cationic leuco dye-like compound with known methods. The cationic compound then is protected by reacting with a nucleophile and coupled with the aminophathalimide by palladium-catalyzed amination to form the protected phthalimide-pentadiene conjugate. The latter is refluxed with hydrazine to convert its phthalimide to the phthalhydrazide and acidified to give the carrier. An additional aspect of the present invention relates to the use of these compounds as antiviral agents for the treatment of viral infections such as HIV and as anticancer agents for the treatment of cancers such as bowel, lung, and breast cancer.

专利号:US-6645513-B2
优先权日:1998-10-26
标题 :Treatment of skin with adenosine or adenosine analog
发明人：DOBSON JR JAMES G; ETHIER MICHAEL F
权利人:UNIV MASSACHUSETTS
摘要:Methods for enhancing the condition of non-diseased skin by application of compositions containing adenosine or an adenosine analog are disclosed. Also disclosed are methods for increasing DNA synthesis or protein synthesis in dermal cells, and methods for increasing dermal cell size, by application of compositions containing adenosine.

专利号:US-8614312-B2
优先权日:2008-02-21
标 题 :Method for preparing nucleotides and related analogues by synthesis on soluble substrate, and biological tools thus prepared
发明人：PEYROTTES SUZANNE; PERIGAUD CHRISTIAN; CRAUSTE CELINE
权利人:PEYROTTES SUZANNE; PERIGAUD CHRISTIAN; CRAUSTE CELINE; CENTRE NAT RECH SCIENT; UNIV MONTPELLIER II
摘要:The invention concerns a method for preparing monomer nucleotides or nucleotide analogues comprising the steps of: (1) coupling a soluble polyethylene glycol support provided with at least one diacid or ether-acid linker and a monomer nucleoside or nucleoside analogue to an amine group or hydroxyl group of the nucleoside with the aid of a coupling agent; (2) at least one step for phosphorylation of said nucleoside or nucleoside analogue coupled to said support with a phosphorylation agent; (3) cleavage of said support and recovery of at least one monomer nucleotide or nucleotide analogue. The nucleotides prepared are biological tools.

专利号:US-2020239500-A1
优先权日:2018-04-04
标 题 :Compositions and Methods for Synthesis of Phosphorylated Molecules

专利号:US-12036300-B2
优先权日:2021-03-31
标题:Methods and compositions for improving skin
发明人：LIAO I-CHIEN; BRIEVA PATRICIA; JUCHAUX FRANCK; BOUEZ CHARBEL; ZHENG QIAN; QIAN KUN
权利人:OREAL
摘要:A method for managing skin tone comprising reducing the synthesis of melanin by applying a skin treatment composition to skin. The skin treatment composition may include about 0.1 to about 25 wt. % of acetyl trifluoromethylphenyl valylglycine; about 0.5 to about 30 wt. % of a polyol; about 0.1 to about 30 wt. % of a silicone, fatty compound, or a mixtures thereof, wherein the skin treatment composition is an emulsion, and all weight percentages are based on the total weight of the skin treatment composition.