CAS: 30827-99-7; 4-(2-Aminoethyl)Benzenesulfonyl Fluoride Hydrochloride

专利信息

专利号:EP-1567195-B1
优先权日:2002-11-26
标题 :Dendrimer conjugates for selective solubilisation of protein aggregates
发明人：HEEGAARD PETER; BOAS ULRIK
权利人:UPFRONT CHROMATOGRAPHY AS
摘要:Dendrimer conjugates are presented, which are formed between a dendrimer and a protein solubilising substance. Such dendrimer conjugates ar effective in the treatment of protein aggregate-related diseases (e.g. prion-related diseases). The protein solubilising substance and the dendrimer together show a protein aggregate solubilising effect higher than a physical mixture of the dendrimer and the protein solubilising substance (i.e. a synergistic effect). Such dendrimer conjugates are useful in the treatment or prevention of protein aggregate-relates diseases, in disinfection/decontamination processes and in classifying or identifying protein aggregates. The synthesis of such dendrimer conjugates from readily-available starting materials is described.

专利号:US-9388431-B2
优先权日:2011-12-23
标 题:Enhanced production of isoprene using host cells having decreased ispA activity
发明人：MCAULIFFE JOSEPH C; MUIR RACHEL E; NIELSEN ALEX T; PERES CAROLINE M; VAVILINE DMITRII V; WELLS DEREK H
权利人:DANISCO US INC; GOODYEAR TIRE & RUBBER
摘要:This invention relates to recombinant microorganisms capable of producing isoprene and isoprene production with the use of such recombinant microorganism with good efficiency. In this invention, functional activity of the ispA gene is altered to reduce the production of isoprenoid molecules in recombinant cells engineered to produce isoprene or in cells otherwise susceptible to isoprenoid accumulation during fermentation. This decreased ispA gene functional activity enables enhanced synthesis of isoprene in a host microorganism.

专利号:US-2007048774-A1
优先权日:1998-05-08
标题 :Continuous in-vitro evolution
发明人：COIA GREGORY; HUDSON PETER J; ILIADES PETER; IRVING ROBERT A
权利人:DIATECH PTY LTD
摘要:Provided is a method for the mutation, synthesis and selection of a protein of interest, by first incubating a replicable RNA molecule encoding the protein with ribonucleoside triphosphate precursors of RNA and an RNA-directed RNA polymerase, such that the RNA-directed RNA polymerase replicates the RNA molecule but introduces mutations thereby generating a population of mutant RNA molecules. The mutant RNA molecules are then incubated with a translation system under conditions which result in the synthesis of a population of mutant proteins. After translation, the mutant proteins are linked to their encoding RNA molecules, and one or more mutant proteins of interest are selected.

专利号:US-2004253689-A1
优先权日:2001-12-17
标 题:Mutants of human insulin-like growth factor binding protein-3 (igfbp-3) and uses thereof
发明人：RECHLER MATHEW
摘要:An isolated or purified nucleic acid molecule consisting essentially of a nucleotide sequence encoding a mutant human IGFBP-3, which can inhibit DNA synthesis, can induce apoptosis, binds to neither human insulin growth factor-I (IGF-I), nor human insulin growth factor-II (IGF-II), and comprises a mutation at Y57; a vector comprising the same, a cell comprising and expressing the same, optionally in the form of a vector; an isolated or purified polypeptide molecule consisting essentially of an amino acid sequence encoding a mutant human IGFBP-3, which can inhibit DNA synthesis, can induce apoptosis, binds to neither human IGF-I nor human IGF-II and comprises a mutation at Y57; a composition comprising the same; and a method of inducing apoptosis in a cell, which method comprises administering to the cell the nucleic acid molecule or polypeptide molecule, in an amount sufficient to induce apoptosis in the cell, whereupon apoptosis is induced in the cell.

专利号:US-2004203096-A1
优先权日:2001-04-09
标题 :Synthesis and secretion of native recombinant lysosomal enzymes by liver
发明人：RABEN NINA; LU NINA; YAN BO; PLOTZ PAUL; RIVERA YESENIA
摘要:The invention provides recombinant native lysosomal enzymes produced by liver cells, preferably in vitro, and methods of using the native recombinant lysosomal enzymes to treat enzyme deficiencies in vivo. Lysosomal enzymes, including acid alpha-glucosidase (GAA), produced by liver cells apparently undergo the post-translational modifications necessary to achieve good enzymatic activity. The resulting enzymes can be taken up by various other cells and can correct phenotypic abnormalities of distant organs with enzyme deficiencies. In certain preferred embodiments, the enzyme is GAA and the methods are especially adapted for treatment of type II glycogen storage disease in mammals, including humans.

专利号:US-2007099915-A1
优先权日:2005-10-07
标题 :Inhibitors of the hiv integrase enzyme
发明人：DRESS KLAUS R; JOHNSON TED W; PLEWE MICHAEL B; TANIS STEVEN P; ZHU HUICHUN
权利人:PFIZER
摘要:The present invention is directed to compounds of formula (I), n nand pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIVâ€?) integrase enzyme.