CAS: 2566-22-5; N-Benzoyl-L-Phenylalanine

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CAS号63-91-2 L-苯丙氨酸 | CAS号98-88-4 苯甲酰氯 | CAS号26348-47-0 2-苯甲酰胺基-(3z)-苯基丙烯酸 | CAS号57427-85-7 (E)-α-(benzamid... | CAS号93-58-3 苯甲酸甲酯 | CAS号67-56-1 甲醇 | CAS号5874-61-3 4-苄基-2-苯基-2-噁唑啉-5-酮 | CAS号1155-48-2 2-(苯甲酰氨基)-3-苯基败脂酸 | CAS号2566-22-5 N-苯甲酰-L-苯丙氨酸 | CAS号3278-14-6 N-苯乙基-苯甲酰胺 | CAS号17350-84-4 2-甲基-D-苯丙氨酸 | CAS号2134-24-9 N-苯甲酰-DL-苯基丙氨酸β-苯基酯 | CAS号21709-69-3 N-(3-oxo-1-phen... | CAS号2566-22-5 N-苯甲酰-L-苯丙氨酸 | CAS号673-06-3 D-苯丙氨酸 | CAS号23239-35-2 a-甲基-L-苯丙氨酸 | CAS号842-74-0 4-苯亚甲基-2-苯基-5(4... | CAS号5874-61-3 4-苄基-2-苯基-2-噁唑啉-5-酮 | CAS号3183-30-0 N-[1-[bis(2-chl...

📜L-苯丙氨酸乙酯盐酸盐置于水,1-羟基苯并三唑,N,N-二异丙基乙胺,Lithium Hydroxide,O‐(1H‐benzotriazol‐1‐yl)‐n,N,N',N'‐tetramethyluronium Tetrafluoroborate体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应 0.33H,反应生成N-苯甲酰-L-苯丙氨酸
参考文献:Subnanomolar Cathepsin S Inhibitors With High Selectivity: Optimizing Covalent Reversible α‐fluorovinylsulfones And α‐sulfonates As Potential Immunomodulators In Cancer
标题:Subnanomolar Cathepsin S Inhibitors With High Selectivity: Optimizing Covalent Reversible α‐fluorovinylsulfones And α‐sulfonates As Potential Immunomodulators In Cancer
摘要:摘要半胱氨酸蛋白酶 Cathepsin S(cats)在许多肿瘤中过度表达.众所周知,它参与了肿瘤的进展以及抗原递呈细胞(apc)的抗原处理.最近的证据表明,沉默 Cats 可以改善几种癌症的抗肿瘤免疫反应.因此,Cats 是调节这些疾病免疫反应的一个有趣靶点.在此,我们介绍了一系列基于α-氟乙烯砜和-磺酸盐弹头的共价可逆 Cats 抑制剂.我们通过分子对接方法优化了两种先导结构,最终得到了 22 种化合物,并在荧光酶测定法中评估了它们对 Cats 的抑制作用以及对非靶标 Catb 和 Catl 的选择性.该系列中最有效的抑制剂具有亚摩尔亲和力(ki=0.08 Nm),对cathepsins B和l的选择性超过100,000倍.
Doi:10.1002/cmdc.202300160

专利信息

专利号:US-10676423-B2
优先权日:2017-02-21
标题 :Structure and synthesis of highly fluorinated amino acid derivatives
发明人：WEAVER JIMMIE DEAN; TEEGARDIN KIP ALLEN; ARORA AMANDEEP
权利人:UNIV OKLAHOMA STATE
摘要:Methods of synthesizing polyfluorinated amino acid derivatives are disclosed, along with polyfluorinated amino acid derivatives produced from said methods, as well as compositions containing same. The synthesis methods utilize an oxazolone and a perfluoroarene to produce the polyfluorinated amino acid derivatives.

专利号:US-10947231-B2
优先权日:2009-05-27
标题:Processes for the preparation of substituted tetrahydro beta-carbolines
发明人：HWANG PETER SEONGWOO; MOON YOUNG-CHOON; TAMIL ARASU; QI HONGYAN; ALMSTEAD NEIL
权利人:PTC THERAPEUTICS INC
摘要:Provided herein are improved processes for the synthesis of substituted tetrahydro beta-carboline derivatives. In particular, provided herein are improved processes useful for the preparation of (S)-4-chlorophenyl 6-chloro-1-(4-methoxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate. Formula (I):

专利号:US-7763734-B2
优先权日:2006-04-19
标题 :Synthesis, structure and use of bisoxazolidines for asymmetric catalysis and synthesis
发明人：WOLF CHRISTIAN; LIU SHUANGLONG
权利人:UNIV GEORGETOWN
摘要:One aspect of the invention relates to chiral bisoxazolidines and their use in asymmetric catalysis. The chiral bisoxazolidines are a novel class of compounds that is expected to find multiple applications, for example, in asymmetric synthesis. For example, a bisoxazolidine ligand enabled the catalytic enantioselective alkynylation and alkylation of a range of aromatic and aliphatic aldehydes, generating chiral propargylic alcohols and secondary alcohols in high yields and enantiomeric excess.

专利号:US-3798241-A
优先权日:1970-12-10
标 题:Bidentate coordinates,their manufacture and application
发明人：KAGAN H; DANG T
权利人:INST FRANCAIS DU PETROLE
摘要:BIDENTATE COORDINATES OF THE FORMULA R2X-R''-YR2, IN WHICH X AND Y ARE PHOSPHORUS, ARSENIC, ANTIMONY OR NITROGEN, R'' IS A HYDROCARBON GROUP CONTAINING AN ASYMMETRIC CARBON ATOM AND THE R GROUPS ARE HYDROCARBON RADICALS, MAY BE ASSOCIATED WITH RHODIUM COMPLEXES TO YIELD HYDROGENATION CATALYSTS USEFUL IN ASYMMETRIC SYNTHESIS. THE SYNTHESIS OF OPTICALLY ACTIVE AMINOACIDS OR AMINES IS CONCERNED.

专利号:US-2020123099-A1
优先权日:2017-02-21
标题 :Structure and Synthesis of Highly Fluorinated Amino Acid Derivatives

专利号:WO-2018156500-A1
优先权日:2017-02-21
标题 :Structure and synthesis of highly fluorinated amino acid derivatives