CAS: 205678-31-5; (S)-2-(8-(2-(6-(Methylamino)Pyridin-2-yl)Ethoxy)-3-Oxo-2-(2,2,2-Trifluoroethyl)-2,3,4,5-Tetrahydro-1H-Benzo[c]Azepin-4-yl)Acetic Acid
该化合物是一个复杂的有机化合物,其特点是多周期结构和各种功能组.该物质具有一种苯[c]氨基核心,该核心以其存在于各种药用活性化合物中而闻名.甲基氨基和丙烯基环的存在表明它可能与生物目标发生互动,使其对药用化学感兴趣.此外,三氟乙基乙基酸组可能增强脂性性和代谢稳定性.该组合表明,它是一种能分子,可影响其生物活动和药用植物基.该化合物可能具有与药物开发有关的特性,特别是在...
- 英文名称(S)-2-(8-(2-(6-(Methylamino)Pyridin-2-yl)Ethoxy)-3-Oxo-2-(2,2,2-Trifluoroethyl)-2,3,4,5-Tetrahydro-1H-Benzo[c]Azepin-4-yl)Acetic Acid
- 中文名称SB273005INTEGRIN抑制剂
- IUPAC名称(S)-2-(8-(2-(6-(methylamino)pyridin-2-yl)ethoxy)-3-oxo-2-(2,2,2-trifluoroethyl)-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-yl)acetic acid
- 其它别名(S)-2-(8-(2-(6-(Methylamino)Pyridin-2-Yl)Ethoxy)-3-Oxo-2-(2,2,2-Trifluoroethyl)-2,3,4,5-Tetrahydro-1H-Benzo[c]Azepin-4-Yl)Acetic Acid | (S)-8-[2-[6-(Methylamino)Pyridin-2-Yl]-1-Ethoxy]-3-Oxo-2-(2,2,2-Trifluoroethyl)-2,3,4,5-Tetrahydro-1H-2-Benzazepine-4-A
- CAS编号205678-31-5
- MFCD编号:MFCD06407695
- FDA UNII编号:HG7MY8V9AA
- 分子式:C22H24F3N3O4分子量:451.45
- 产品CID: 1042702
- 产品分类生物化工 → 抑制剂 → 细胞骨架(Cytoskeletal Signaling)
物理性质
- 沸点662.9±55.0 °C(预测)
- 密度1.321±0.06 g/cm3(预测)
- pKa:4.32±0.10(预测)
- LogP:3
- 溶解性Soluble In DMSO
- 外观形态白色至类白色粉末
- 储存条件储存在 -20°C
- 产品应用该化合物是一种强效内酯抑制剂,其应用是抑制ΑΒ3和ΑΒ5受体(基=1.2纳米和0.3纳米);抑制人体骨质表面中分辨率在体外吸附(IC50=11纳米);结合乳胶,它抑制肿瘤细胞在含有MDA-MB-231细胞的血液中吸附于血管外细胞基体(EMM);在骨吸附和和骨质疏松松症的老鼠模型中,它压制了对准甲醇激素刺激的卡尔塞反应,防止了骨质流失;在有急性动脉炎的老鼠体内,它显著缓解了动脉膜炎症状;它与乳房炎结合,在高剂量情况下,它会诱发血管滑动肌肉细胞细胞细胞(VSMCS)急性,中转性内核素,在小鼠的血管腹部和肾动脉中,在怀孕小鼠体内,它将TH1细胞源的IL-2减少和TH2细胞源IL-10高压.
MSDS等安全信息
上下游产品
methyl (S)-8-[2-[6-(methylamino)pyridin-2-yl]-1-ethoxy]-3-oxo-2-(2,2,2-trifluoroethyl)-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetate 2-Amino-6-methylpyridine 2-methylamino-6-(2-hydroxyethyl)pyridine 2-(tert-butoxycarbonylamino)-6-picoline合成工艺路线路线简述
📜6-甲基吡啶-2-氨基甲酸叔丁酯置于盐酸,Sodium Hydroxide,锂硼氢,偶氮二甲酸二异丙酯,Sodium Hydride,苯甲醚,三苯基膦,Lithium Diisopropyl Amide体系中,用 四氢呋喃,1,4-二氧六环,甲醇,N,N-二甲基甲酰胺 用作溶剂,化学反应 2.0H,反应生成Sb273005Integrin抑制剂
参考文献:基于2-苯并ze庚因gly-Asp模拟物的口服活性非肽玻连蛋白受体拮抗剂的发现.
标题:基于2-苯并ze庚因gly-Asp模拟物的口服活性非肽玻连蛋白受体拮抗剂的发现.
摘要:
Doi:10.1021/jm990446U
海关参考信息
- 2902600000-乙苯
2905121000-正丙醇
2905130000-正丁醇
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-11723888-B2
优先权日:2021-12-09
标 题:Polymer conjugated thyrointegrin antagonists
发明人：MOUSA SHAKER A; HAY BRUCE A; KARAKUS OZLEM OZEN
权利人:NANOPHARMACEUTICALS LLC
摘要:Chemical compounds/compositions, methods of synthesis, and methods of use are provided. The compounds/compositions are directed toward thyrointegrin antagonists directly conjugated to a polymer. The compounds/compositions may further comprise an additional substituent also conjugated to the polymer. The compounds/compositions may demonstrate antiangiogenic effect and efficacy against conditions, particularly cancers.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Wang S, Zhou X, Yang J. Integrin αvβ3 Is Essential for Maintenance of Decidua Tissue Homeostasis and of Natural Killer Cell Immune Tolerance During Pregnancy. Reprod Sci. 2018 Jan
1:1933719117746766. doi: 10.1177/1933719117746766. [Epub ahead of print] Epub 2014 Apr 7.
3: Dalmas Wilk DA, Scicchitano MS, Morel D. In vitro investigation of integrin-receptor antagonist-induced vascular toxicity in the mouse. Toxicol In Vitro. 2013 Feb;27(1):272-81. doi: 10.1016/j.tiv.2012.08.028. Epub 2012 Sep 1.
合成参考文献
参考文献:10.1124/mol.119.115964
摘要:Lee TD, Lee OW, Brimacombe KR, Chen L, Guha R, Lusvarghi S, Tebase BG, Klumpp-Thomas C, Robey RW, Ambudkar SV, Shen M, Gottesman MM, Hall MD. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular Pharmacology. 2019 Nov;96(5):629–40. doi: 10.1124/mol.119.115964.
参考文献:10.1007/s40475-025-00347-1
摘要:Robles-Minutti JN, Cuapa-González MA, Márquez-Domínguez L, Arenas-Hernández MMP, Santos-López G. Unlocking the Gate: Keys to Understanding Zika Virus Interactions with Human Cell Receptors. Curr Trop Med Rep. 2025 Apr 08;12(1). doi: 10.1007/s40475-025-00347-1.
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