专利号:US-6353112-B1 优先权日:1998-07-17 标 题:Sultams: Solid phase and other synthesis of anti-HIV compounds and compositions 发明人:BAKER DAVID C; JIANG BIN 权利人:UNIV TENNESSEE RES CORP 摘要:Biologically active sultams are disclosed which have potent anti-HIV activity. A combinational method of synthesis, which uses a solid support and variants thereof, are described. Biological compositions and method of treating mammals for viral infections with compositions comprising the sultams of the invention, especially HIV are described.
专利号:US-8709811-B2 优先权日:2003-10-03 标 题:Materials and methods for synthesis of a flavor and aroma volatile in plants 发明人:KLEE HARRY J; TIEMAN DENISE 权利人:KLEE HARRY J; TIEMAN DENISE; UNIV FLORIDA 摘要:The subject invention concerns polynucleotides encoding a plant 2-phenylethanol dehydrogenase enzyme. In one embodiment, the polynucleotide encodes a tomato 2-phenylethanol dehydrogenase. The subject invention also concerns polynucleotides encoding a plant phenylalanine decarboxylase enzyme. In one embodiment, the polynucleotide encodes a tomato phenylalanine decarboxylase. The subject invention also concerns 2-phenylethanol dehydrogenase polypeptides and phenylalanine decarboxylase polypeptides encoded by polynucleotides of the present invention. The subject invention also concerns methods for providing a plant with an increased flavor and aroma volatile. Plants can be transformed with one or more polynucleotide of the present invention. The subject invention also concerns these transformed plant cells, plant tissue, and plants and transgenic progeny thereof.
专利号:US-8114993-B2 优先权日:2007-02-06 标题:Use of aryl chlorides in palladium-catalyzed C-H bond functionalization 发明人:DAUGULIS OLAFS; CHIONG HENDRICH 权利人:DAUGULIS OLAFS; CHIONG HENDRICH; UNIV HOUSTON SYSTEM 摘要:A one-step method for efficiently converting carbon-hydrogen bonds into carbon-carbon bonds using chloroarenes and palladium catalysts is disclosed. This method allows faster introduction of complex molecular entities, a process that would otherwise require many more steps. This invention is particularly relevant for the organic synthesis of complex molecules such as, but not limited to, pharmacophores.
专利号:US-8921583-B2 优先权日:2007-10-04 标题:Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides 发明人:PHIASIVONGSA PASIT; SEHL LOUIS C; FULLER WILLIAM DEAN; LAIDIG GUY J 权利人:ONYX THERAPEUTICS INC 摘要:The invention relates to crystalline peptide keto epoxide compounds, methods of their preparation, and related pharmaceutical compositions. This invention also relates to methods for the preparation of amino acid keto-epoxides. Specifically, allylic ketones are stereoselectively converted to the desired keto epoxides.
专利号:US-2013150290-A1 优先权日:2007-10-04 标 题:Crystalline Peptide Epoxy Ketone Protease Inhibitors and the Synthesis of Amino Acid Keto-Epoxides
专利号:US-2009105156-A1 优先权日:2007-10-04 标 题:Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides
[参考文献]: K F Christiansen, Et Al. Flavor Release Of The Tomato Flavor Enhancer, 2-Isobutylthiazole, From Whey Protein Stabilized Model Dressings. Food Sci Technol Int. 2011 Apr;17(2):143-54. [参考文献]: Yair Bezman, Et Al. Differential Effects Of Tomato (Lycopersicon Esculentum Mill) Matrix On The Volatility Of Important Aroma Compounds. J Agric Food Chem. 2003 Jan 29;51(3):722-6.
合成参考文献
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