CAS: 165450-17-9; (S)-3-((3,3-Dimethylbutyl)Amino)-4-(((S)-1-Methoxy-1-Oxo-3-Phenylpropan-2-yl)Amino)-4-Oxobutanoic Acid

上下游产品

CAS号2987-16-8 3,3-二甲基丁醛 | CAS号22839-47-0 阿斯巴甜

L-苯丙氨酸甲酯置于吡啶,四溴化碳,Palladium On Activated Carbon,氢气,Sodium Cyanoborohydride体系中,用 甲醇,二氯甲烷,乙腈 用作溶剂,化学反应 30.0H,反应生成纽甜
参考文献:通过吡啶-Cbr4 的新型羧酸光活化模式直接形成酰胺键的高效光介导方案
标题:通过吡啶-Cbr4 的新型羧酸光活化模式直接形成酰胺键的高效光介导方案
摘要:提出了利用吡啶-Cbr 4的新型光活化模式,由羧酸和胺或氨基酸uva光介导合成酰胺.Di-Hrms 的机理研究为各种中间体的形成提供了实验证据.展示了在工业上有趣的或生物活性化合物的合成中的应用.
Doi:10.1002/chem.202300556

专利信息

专利号:US-7193103-B2
优先权日:2000-05-19
标题:Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester using oxazolidinone derivatives
发明人：PRAKASH INDRA
权利人:NUTRASWEET CO
摘要:Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester by treating N-(3,3-dimethylbutyl)-L-aspartic acid with ketones to give oxazolidinone derivatives, which are condensed with L-phenylalanine methyl ester.

专利号:US-8034969-B2
优先权日:2003-05-06
标 题:Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester using 3,3-dimethylbutyraldehyde precursors
发明人：PRAKASH INDRA; FURLONG KENNETH E; JACKSON III HANDLEY E
权利人:NUTRASWEET CO
摘要:N—[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester is produced by hydrogenation of L-α-aspartyl-L-phenylalanine 1-methyl ester and 3,3-dimethylbutyraldehyde produced in situ by the hydrolysis or cleavage of a 3,3-dimethylbutyraldehyde precursor. The production method is efficient and low cost, as compared with conventional N—[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester synthesis.

专利号:US-6642406-B2
优先权日:2000-05-18
标 题 :Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester using L-α-aspartyl-L-phenylalanine 1-methyl ester precursors
发明人：PRAKASH INDRA; GUO ZHI; SCHROEDER STEVE; WACHHOLDER KURT L
权利人:NUTRASWEET CO
摘要:N-[N-(3,3-dimethylbutyl)-L-alpha-aspartyl]-L-phenylalanine 1-methyl ester is produced by hydrogenation of a mixture of 3,3-dimethylbutyraldehyde and a precursor of L-alpha-aspartyl-L-phenylalanine 1-methyl ester. In particular, N-[N-(3,3-dimethylbutyl)-L-alpha-aspartyl]-L-phenylalanine 1-methyl ester is produced using an acid salt of L-alpha-aspartyl-L-phenylalanine 1-methyl ester or N-protected L-alpha-aspartyl-L-phenylalanine 1-methyl ester. The production method is efficient and low cost, as compared with conventional N-[N-(3,3-dimethylbutyl)-L-alpha-aspartyl]-L-phenylalanine 1-methyl ester synthesis.

专利号:US-6281380-B1
优先权日:2000-05-18
标 题:Synthesis of N-(N-(3,3-dimethylbutyl)-L-α-aspartyl)L-phenylalanine1-methyl ester by reductive alkylation and crystallization/ isolation in aqueous methanol
发明人：PRAKASH INDRA; SCAROS MIKE G; WACHHOLDER KURT L
权利人:NUTRASWEET CO
摘要:N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester is produced by reductive alkylation and crystallization/isolation in methanol and water. The production method is efficient and low cost, as compared with conventional N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester synthesis and results in high purity N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester.

专利号:US-12043612-B2
优先权日:2020-05-09
标 题 :Methods of manufacturing a bifunctional compound, ultrapure forms of the bifunctional compound, and dosage forms comprising the same
发明人：ALLAN LAURA E N; CHEN CHUNGPIN HERMAN; DONG HANQING; GROSSO JOHN A; HASKELL III ROYAL J; LLOYD RHYS; REECE HAYLEY
权利人:ARVINAS OPERATIONS INC
摘要:The present disclosure relates to ultra-pure forms, polymorphs, amorphous forms, and formulations of N-[(1r,4r)-4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-({4-[2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]piperazin-1-yl}methyl)piperidin-1-yl]pyridazine-3-carboxamide, referred to herein as Compound A:The present disclosure also relates methods of manufacturing and purifying the same, as well as intermediates useful in the synthesis of Compound A. The ultra-pure forms, polymorphs, amorphous forms, and formulations of Compound A can be used as therapeutic agents for the treatment of various diseases and conditions such as cancer.

专利号:US-2017204442-A1
优先权日:2014-05-29
标题 :Enzymatic synthesis of soluble glucan fiber
发明人：DICOSIMO ROBERT; CHENG QIONG; ELIOT ANDREW C; OUWEHAND ARTHUR; PAYNE MARK S; YOU ZHENG
权利人:DU PONT
摘要:An enzymatically produced soluble α-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble α-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble α-glucan fiber are also provided.