CAS: 158063-66-2; 4-(Trifluoromethyl)Nicotinic Acid

相似化合物

13600-43-6 175204-82-7 1083197-78-7

上下游产品

CAS号13600-43-6 3-氰基-4-三氟甲基吡啶 | CAS号158062-71-6 4-(三氟甲基)烟酰胺 | CAS号60838-50-8 3-甲氧基丙烯腈 | CAS号120417-45-0 (3E)-4-Amino-1,... | CAS号590371-81-6 2-氯-4-(三氟甲基)吡啶-3-羧酸 | CAS号3796-24-5 4-三氟甲基吡啶 | CAS号124-38-9 二氧化碳 | CAS号625115-02-8 3-碘-4-三氟甲基吡啶 | CAS号81565-18-6 2-氯-4-(三氟甲基)吡啶 | CAS号198401-76-2 (4-三氟甲基-3-吡啶)-甲醇 | CAS号1083197-78-7 4-(三氟甲基)烟醛 | CAS号158062-71-6 4-(三氟甲基)烟酰胺 | CAS号175204-82-7 4-(三氟甲基)烟酸甲酯 | CAS号955997-27-0 1-(4-(三氟甲基)吡啶-3-基)乙酮

4-三氟甲基吡啶置于2,2,6,6-四甲基哌啶,正丁基锂,碘体系中,用 四氢呋喃,正己烷 用作溶剂,化学反应 2.03H,反应生成4-三氟甲基烟酸
参考文献:三氟甲基取代的吡啶和喹啉的直接金属化和后续功能化
标题:三氟甲基取代的吡啶和喹啉的直接金属化和后续功能化
摘要:根据试剂的选择,2-(三氟甲基)吡啶可以被选择性地金属化并随后在3-位或6-位被羧化或以其他方式官能化."可选的位点选择性"也可以用 4-(三氟甲基)吡啶来实现,它可以在 2-位或 3-位去质子化.相反,3-(三氟甲基)吡啶发生亲核加成.和随之而来的解体.不管是什么基地.根据反应条件,2-(三氟甲基)喹啉在其 3-,4-或 8-位对锂试剂显示反应性,在 2-或 4-位对 3-(三氟甲基)喹啉和 4-(三氟甲基)喹啉)喹啉在 2 位或 3 位.因此可以进行准备.四种三氟甲基取代的吡啶羧酸和六种三氟甲基取代的喹啉羧酸,区域异构未受污染,并且以最直接的方式.[在 Scifinder (R) 上]
Doi:10.1002/ejoc.200390216

专利信息

专利号:JP-H10508011-A
优先权日:1994-10-26
标 题:Synthesis of polyunsaturated fatty acid analogs

专利号:CN-113166767-B
优先权日:2018-09-05
标 题 :Method for engineering synthesis of cis-regulatory DNA

专利号:CN-113166767-A
优先权日:2018-09-05
标 题:Method for engineering synthesis of cis-regulated DNA

专利号:CN-118437123-A
优先权日:2024-05-14
标题:Waste gas recovery device based on synthesis of 4-trifluoromethyl nicotinic acid

专利号:US-2008139558-A1
优先权日:2006-02-24
标题 :Quinolones useful as inducible nitric oxide synthase inhibitors
发明人：SMITH NICHOLAS D; ROPPE JEFFREY R; BONNEFOUS CELINE; PAYNE JOSEPH E; ZHUANG HUI; CHEN XIAOHONG; LINDSTROM ANDREW K; DURON SERGIO G; HASSIG CHRISTIAN A; NOBLE STEWART A
权利人:KALYPSYS INC
摘要:The present invention relates to novel quinolones of Formula I that inhibit inducible NOS synthase together with methods of synthesizing and using the compounds including methods for inhibiting or modulating nitric oxide synthesis and/or lowering nitric oxide levels in a patient by administering the compounds for the treatment of disease.

专利号:WO-2025055006-A1
优先权日:2023-09-13
标 题 :Matrine derivative, preparation method therefor, and use thereof
发明人：ZHANG JIE; CHEN TINGZHUO; RONG BO; QIAN SHAN; TANG QINGQING; DU BO; WU YUXIANG; REN DAN; HE QIMING
权利人:CHENGDU NEWSUN CROP SCIENCE CO LTD
摘要:The present application relates to the field of organic synthesis. Disclosed are a matrine derivative, a preparation method therefor, and a use thereof. By taking sophora acid methyl ester as a raw material, a nucleophilic substitution or nucleophilic addition reaction is carried out under an alkaline condition, to obtain a series of new matrine derivatives in one step. The matrine has certain insecticidal activity, but the insecticidal effect is not ideal; however, the activity of the matrine is multiplied by modifying the structure of the matrine and is obviously superior to that of the matrine before structural modification; in addition, some compounds also have an inhibitory effect on the activity of SIRT enzymes.