CAS: 1532-72-5; Isoquinoline N-Oxide

相似化合物

1973504-60-7 3947-77-1 86377-01-7

上下游产品

CAS号119-65-3 异喹啉 | CAS号91-21-4 1,2,3,4-四氢异喹啉 | CAS号77123-58-1 2-[(三甲基甲硅烷基)乙炔基]苯甲醛 | CAS号6630-33-7 2-溴苯甲醛 | CAS号25705-34-4 2-甲酰基苯乙醛 | CAS号491-30-5 异喹诺酮 | CAS号3336-49-0 4-羟基异喹啉 | CAS号142052-73-1 4-(2H-isoquinol... | CAS号1721-93-3 1-甲基异喹啉 | CAS号40615-08-5 1-(氨甲基)异喹啉 | CAS号91-21-4 1,2,3,4-四氢异喹啉 | CAS号46502-61-8 异喹啉-1-乙酸乙酯 | CAS号58245-97-9 4-acetoxyisoqui... | CAS号27302-13-2 1-Isoquinolinea...

异喹啉置于二甲基二环氧乙烷体系中,用 丙酮 用作溶剂,以98%的收率获得异喹啉-N-氧化物
参考文献:二甲基二环氧乙烷对 2-取代吡啶和喹啉的 N-氧化:动力学和空间效应
标题:二甲基二环氧乙烷对 2-取代吡啶和喹啉的 N-氧化:动力学和空间效应
摘要:在大多数情况下,二甲基二环氧乙烷 (1) 氧化 2-取代的吡啶和选定的含 /v 的芳族杂环产生相应的 A/-氧化物作为唯一的产物,在大多数情况下是定量的.对于一系列 2-取代的吡啶 2-10,喹啉 11-14 和异喹啉 15,16,在 23 oc 的干燥丙酮中确定了 1 V-氧化的二级速率常数.除了 2-F-丁基吡啶的数据外,2-取代吡啶(r = Me,Et,Pr",Pr',3-戊基)的 Log K2 与 Taft (σ*) 常数具有极好的相关性.取代喹啉和异喹啉的结果与用吡啶观测到的趋势相同.由于 2-取代和周围相互作用引起的空间效应可以显着降低反应性.结果提供了对二甲基二环氧乙烷 A/-氧化的几何要求的见解.简介 二环氧乙烷是多功能的亲电氧原子转移剂,用于氧化有机底物上的各种官能团.由于制备的简便性和经济性,二甲基二环氧乙烷 (1) 已被广泛研究.已经开发了几种方法用于 1 原位或在溶液中分离.烯烃被
Doi:10.1515/hc.2007.13.1.25

专利信息

专利号:US-5877278-A
优先权日:1992-09-24
标题:Synthesis of N-substituted oligomers
发明人：ZUCKERMANN RONALD N; GOFF DANE A; NG SIMON; SPEAR KERRY; SCOTT BARBARA O; SIGMUND AARON C; GOLDSMITH RICHARD A; MARLOWE CHARLES K; PEI YAZHONG; RICHTER LUTZ; SIMON REYNA
权利人:CHIRON CORP
摘要:A solid-phase method for the synthesis of N-substituted oligomers, such as poly (N-substituted glycines) (referred to herein as poly NSGs) is used to obtain oligomers, such as poly NSGs of potential therapeutic interest which poly NSGs can have a wide variety of side-chain substituents. Each N-substituted glycine monomer is assembled from two 'sub-monomers' directly on the solid support. Each cycle of monomer addition consists of two steps: (1) acylation of a secondary amine bound to the support with an acylating agent comprising a leaving group capable of nucleophilic displacement by -NH2, such as a haloacetic acid, and (2) introduction of the side-chain by nucleophilic displacement of the leaving group, such as halogen (as a solid support-bound alpha -haloacetamide) with a sufficient amount of a second sub-monomer comprising an -NH2 group, such as a primary amine, alkoxyamine, semicarbazide, acyl hydrazide, carbazate or the like. Repetition of the two step cycle of acylation and displacement gives the desired oligomers. The efficient synthesis of a wide variety of oligomeric NSGs using automated synthesis technology of the present method makes these oligomers attractive candidates for the generation and rapid screening of diverse peptidomimetic libraries. The oligomers of the invention, such as N-substituted glycines (i.e. poly NSGs) disclosed here provide a new class of peptide-like compounds not found in nature, but which are synthetically accessible and have been shown to possess significant biological activity and proteolytic stability. Combinatorial libraries of cyclic compounds are disclosed wherein the cyclic compounds are comprised of at least one ring structure derived from cyclization of a peptoid backbone. The diversity of product compounds is generated by the sequential addition of substituted submonomers. The combinatorial library includes 10 or more, preferably 100 or more, and more preferably 1,000 or more distinct and different compounds. The library includes each of the product compounds in retrievable and analyzable amounts and preferably includes at least one biologically active compound. Methods of synthesizing the combinatorial libraries and assay devices produced using the libraries are disclosed as is methodology for screening for and obtaining biologically active cyclic organic compounds.

专利号:US-2024174698-A1
优先权日:2022-09-23
标题 :Modular synthesis of 1,2-azaborines via ring-opening bn-isostere benzannulation
发明人：DONG GUANGBIN; LYU HAIRONG; CHEN ZHIJIE; WU YIFEI; CHOI SHINYOUNG
权利人:UNIV CHICAGO
摘要:The present disclosure relates generally to 1,2-azaborines and methods of making the same.

专利号:US-7365197-B2
优先权日:2000-12-29
标题 :Method for the regioselective preparation of substituted benzo[g]quinoline-3-carbonitriles and benzo[g]quinazolines
发明人：BERGER DAN MAARTEN; BIRNBERG GARY HAROLD; WANG YANONG
权利人:WYETH CORP
摘要:This invention relates to a method for the regioselective synthesis of 4,6,7,8-substituted benzo[g]quinoline-3-carbonitriles and 4,6,7,8-substituted benzo[g]quinazolines as well as intermediates thereof. The compounds derived from this invention are useful for the treatment of a variety of diseases that are a result of deregulation of these PTK's, and more specifically, are anti-cancer agents and are useful for the treatment of cancer in mammals. In addition, the compounds derived from this invention are useful for the treatment of polycystic kidney disease in mammals.

专利号:US-2005124683-A1
优先权日:2003-09-17
标 题:HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
发明人：ALEGRIA LARRY A; CANAN-KOCH STACIE S; DRESS KLAUS R; HUANG BUWEN; KUMPF ROBERT A; LEWIS KATHLEEN K; MATTHEWS JEAN J; SAKATA SYLVIE K; VIRGIL SCOTT C
权利人:AGOURON PHARMA
摘要:The present invention relates to a series of chemical compounds useful as Human Immunodeficiency Virus (HIV) protease inhibitors and to the use of such compounds as antiviral agents. The invention further relates to pharmaceutical compositions containing such antiviral agents, and their uses and materials for their synthesis

专利号:US-7179918-B2
优先权日:2001-06-11
标 题:HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
发明人：CANAN KOCH STACIE S; ALEXANDER THERESE N; BURKE BENJAMIN J; JEWELL TANYA M; KUCERA DAVID J; LINTON MARIA ANGELICA; MITCHELL JR LENNERT J; REICH SIEGFRIED H; SKALITZKY DONALD J; TATLOCK JOHN H; VARNEY MICHAEL D; VIRGIL SCOTT C; WEBBER STEPHEN E; WORLAND STEPHEN T; BARVIAN MARK; BOLTON GARY; BOYER JR FREDERICK EARL; MACHAK JEFFREY J; HOLLER TOD; MURPHY SEAN T; MELNICK MICHAEL; JOSYULA VARA PRASAD
权利人:AGOURON PHARMA
摘要:Compounds of the formula: n nwhere the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.

专利号:US-2009215080-A1
优先权日:2005-10-13
标题:Methods for identification of inhibitors of enzyme activity
发明人：SINHA SUKANTO; CHILCOTE TAMIE JO
权利人:ACTIVESITE PHARMACEUTICALS
摘要:The invention discloses compositions and methods of synthesis to create novel ligands and drugs and identifying such compounds as inhibitors of enzyme targets for use in the treatment of clinical disorders, including cancer, infectious diseases, parasitic infestations, neurological disorders, reproductive disorders, inflammatory disorders, circulatory disorders, and metabolic disorders.